Rapid cancer diagnosis by highly fluorescent carbon nanodots-based imaging

Duan, Qianqian; Che, Mingxuan; Hu, Shengliang; Zhao, Haichao; Li, Yang; Ma, Xianyong; Zhang, Wendong; Zhang, Yixia; Sang, Shengbo

doi:10.1007/s00216-018-1500-1

Cited by 32 publications

(16 citation statements)

References 36 publications

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“…), dopamine, Cysteine, antibiotics (including tetracycline, oxytetracycline) and so on. Up to now, red, green and blue luminescent CDs have been synthesized using the solvothermal method, where o‐phenylenediamine, m‐phenylenediamine and p‐phenylenediamine are taken as the source of carbon …”

Section: Introductionmentioning

confidence: 91%

Carbon Dots Synthesized and its Applications in the Detection of Chlortetracycline and Water Based on the Aggregation‐Induced Emission

Hou

Yuan

et al. 2020

ChemistrySelect

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In recent years, carbon dots (CDs) have attracted widespread attention for their unique structure and excellent optical properties. In this study, orange‐red emission CDs were prepared using the one‐pot solvothermal carbonization method in ethanol medium. The fluorescence of the CDs was enhanced significantly in the presence of chlortetracycline (CTC), which was accompanied by the blue shift of emission wavelength in ethanol medium, and the enhancement of fluorescence intensity was proportional to CTC concentration in the range of 1.00×10−8 to 5.00×10−6 mol/L with the detection limit of 3.30 nmol/L. As revealed by the mechanism study, the enhanced fluorescence of the CDs by CTC was attributed to the aggregation‐induced emission (AIE). Besides, the AIE effect on the mixture of CDs and CTC was down‐regulated significantly in the presence of water, while the down‐regulated fluorescence intensity was proportional to water concentration in the range between 2.21×10−4 and 1.35×10−3 mol/L with the detection limit of 3.29×10−5 mol/L. Based on the above‐mentioned fact, a simple method for dual response to CTC and trace water was developed, and it exhibited excellent sensitivity and selectivity.

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Section: Introductionmentioning

confidence: 91%

Carbon Dots Synthesized and its Applications in the Detection of Chlortetracycline and Water Based on the Aggregation‐Induced Emission

Hou

Yuan

et al. 2020

ChemistrySelect

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“…However, most of these methods show some limitations, such as complicated processing, high cost of instruments, and time-consuming operations . Carbon dots (CDs), as a new type of emerging materials, are superior to the traditional semiconductor quantum dots because of their excellent optical properties, such as biocompatibility, anti-photodegradation, and low toxicity, , and have been used in various applications such as in vitro and in vivo imaging, , disease diagnosis, drug carrier, , fluorescent probe, and so on.…”

Section: Introductionmentioning

confidence: 99%

Dual-Response Detection of Oxidized Glutathione, Ascorbic Acid, and Cell Imaging Based on pH/Redox Dual-Sensitive Fluorescent Carbon Dots

et al. 2020

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The pH/redox dual-sensitive fluorescent carbon dots (pHRCDs) with the fluorescence quantum yield of 16.97% were synthesized by the pyrolysis of L-glutamic acid (L-glu) and dopamine (DA). Compared with the quantum dot (QD)−dopamine conjugate, when the pH value of the solution was changed from neutral to alkaline, the pHRCDs exhibited unique optical phenomenon including red-shift of fluorescence peak and the fluorescence intensity first decreasing from pH 7 to 10 and then increasing from pH 10 to 13. The pHRCDs could be developed for a discriminative and highly sensitive dual-response fluorescent probe for the detection of oxidized glutathione (GSSG) and ascorbic acid (AA) activity in human blood. Under the optimized experimental conditions, the dual-response fluorescent probe can detect GSSG and AA in the linear range of 1.2−3.6 and 27−35 μM with the detection limits of 0.1 and 3.1 μM, respectively. In addition, the pHRCDs demonstrated low cytotoxicity and good biocompatibility, which can be well applied to in vitro cell imaging, and the pHRCDs/GSH fluorescence system has been successfully developed for the detection of AA in real samples.

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“…2 In recent years, the long-wavelength emitting CDs have been the focus of researchers because of their promising potential in cell imaging, [3][4][5] in vivo imaging, 6,7 and in vivo labeling and diagnosis. 8,9 The reports and papers on green, yellow and orange emitting CDs [10][11][12] have been widely seen in published journals, but the ones on red-emitting CDs 13 are relatively scarce.…”

Section: Introductionmentioning

confidence: 99%

One-step synthesis of red-emitting carbon dots via a solvothermal method and its application in the detection of methylene blue

et al. 2019

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Rapid cancer diagnosis by highly fluorescent carbon nanodots-based imaging

Cited by 32 publications

References 36 publications

Carbon Dots Synthesized and its Applications in the Detection of Chlortetracycline and Water Based on the Aggregation‐Induced Emission

Carbon Dots Synthesized and its Applications in the Detection of Chlortetracycline and Water Based on the Aggregation‐Induced Emission

Dual-Response Detection of Oxidized Glutathione, Ascorbic Acid, and Cell Imaging Based on pH/Redox Dual-Sensitive Fluorescent Carbon Dots

One-step synthesis of red-emitting carbon dots via a solvothermal method and its application in the detection of methylene blue

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