Rapid assessment of drug-related HIV risk among men who have sex with men in three South African cities

Parry, Charles D. H.; Petersen, P. Brent; Dewing, Sarah; Carney, Tara; Needle, Richard; Kroeger, Karen; Treger, Latasha

doi:10.1016/j.drugalcdep.2007.12.005

Cited by 64 publications

(79 citation statements)

References 17 publications

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“…This has also been shown in other settings such as Thailand and China where studies on MSM in relation to HIV suggest * Correspondence: Dr. Adamson Muula; E-mail: muula@email.unc.edu Socio-demographic characteristics and sexual health related attitudes and practices of men having sex with men in central and southern Malawi that HIV prevalence may be much higher than the 'general' or heterosexual population (CDC, 2006;Liu et al, 2006). However differences in risk behaviours among MSM between different settings may occur (Parry et al, 2008). Recently, Sanders et al, (2007) have reported that less than 2% of MSM in Kenya were using illicit drugs whereas in South Africa the prevalence has been reported to exceed 25% (Parry et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

“…The available evidence however highlights to multiple opportunities for interventions that may reduce health risk. In a study in South Africa, Parry et al (2008) have reported high HIV knowledge, low prevention practice and associated drug use among MSM. Baral et al (2007) and Liu et al (2006) have reported that HIV prevalence is much higher among MSM compared to the 'general' community.…”

Section: Introductionmentioning

confidence: 99%

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Socio-demographic characteristics and sexual health related attitudes and practices of men having sex with men in central and southern Malawi

Ntata¹,

Muula²,

Siziya³

2008

Tanzania J Hlth Res

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An exploratory study of men having sex with men (MSM) was conducted in central and southern Malawi in order to understand their socio-demographic characteristics, sexual behaviours, and perceptions about confidentiality and stigma. A total of 97 men participated in the study of whom 84 (86.6%) were in the age group 17-32 years. The majority, 73 (75.3%) of MSM had never married, 26 (32.5%) reported not always using condoms during sexual intercourse, and 23 (23.7%) had ever received money or gifts in exchange of sex. Only 17 (17.5%) of the participants reported being exposed to HIV prevention messages targeted at MSM. Fear of sexual orientation disclosure and discrimination were reported by 27 (30.7%) of MSM. Many of the study participants reported that HIV intervention programmes are not accessible to them. In conclusion, HIV intervention programmes may not be reaching out to the majority of MSM. We suggest an exploration of the feasibility of HIV prevention interventions targeting MSM in this country where the practice is illegal. _________________________________________________________________________________________

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Socio-demographic characteristics and sexual health related attitudes and practices of men having sex with men in central and southern Malawi

Ntata¹,

Muula²,

Siziya³

2008

Tanzania J Hlth Res

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“…18,19 Drug use: drinking and drug use lead to less efficient use of condoms. [20][21][22] Income: an average monthly income higher than 300 dollars has been associated with HIV infection among MSM in Nanjing, China. 23 Although many studies have investigated risk factors for HIV infection among MSM in China, the results are not conclusive and may not be applicable to Yunnan, as China is a multiethnic society with significant differences in living habits, local culture and demographics.…”

Section: Introductionmentioning

confidence: 99%

Factors influencing HIV infection in men who have sex with men in China

Xu¹,

Jia²,

Xiao³

et al. 2013

Asian J Androl

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To identify risk factors for HIV infection among men who have sex with men (MSM) and to provide a theoretical basis for prevention interventions. Between December 2011 and August 2012, a case-control study was conducted among MSM who underwent voluntary counselling and testing for HIV. Confirmed HIV-positive MSM were included in the case group, and HIV-negative MSM were included in the control group. Information on possible risk factors was collected by a survey questionnaire and a qualitative interview. The results of a conditional logistic regression showed that the following were influencing factors for HIV infection: average monthly income between 2001 and 3000 Yuan (odds ratio (OR)56.341, 95% CI: 1.714-12.544), only sometimes using condoms when having anal sex with men in the last 6 months (OR57.601, 95% CI: 1.359-23.083), having HIV-positive sex partners (OR55.273, 95% CI: 1.572-17.691), rectal trauma with bleeding in the last 6 months (OR52.947, 95% CI: 1.308-6.638), not using condoms at last sexual encounter (OR51.278, 95% CI: 1.012-5.595), engaging in commercial sex (OR55.925, 95% CI: 1.923-13.890) and having more than 16 sex partners in the last 6 months (OR51.175, 95% CI: 1.021-1.353). These seven factors were the risk factors of HIV infection (OR.1). However, having anal sex less than 10 times in the previous 1 month (OR50.002, 95% CI: 0.000-0.287) was a protective factor against HIV infection among MSM (OR,1), and insertive (OR50.116, 95% CI: 0.000-0.236) (OR,1) anal intercourse influenced HIV infection. Interventions should be targeted at MSM whose average monthly income is between 2001 and 3000 Yuan, and who engage in commercial sex. In addition, the importance of using condoms at every sexual encounter should be emphasised in health education, as should the treatment of rectal trauma with bleeding. Finally, MSM should decrease the number of sex partners and frequency of anal sex to decrease the rate of HIV infection.

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“…Surveys in Cape Town, Durban and Pretoria, South Africa, found that use of crack cocaine, methamphetamine and other drugs to facilitate sexual encounters is common among men who have sex with men (Parry et al, 2008).…”

Section: Men Who Have Sex With Menmentioning

confidence: 99%

An old enzyme for current needs: adenosine deaminase and a dendritic cell vaccine for HIV

et al. 2011

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After nearly three decades of searching for a vaccine against HIV, a cure for this pandemic disease still remains elusive. The low immunogenicity of the surface proteins and the huge variability of the virus, together with the immunocompromised status of the host, have made developing an HIV vaccine an uphill battle. Over the past few years, both immunogen design and immunization strategies have improved, providing hope for future, although the anti‐HIV responses achieved still remain modest. As developing a prophylactic vaccine seems unlikely nowadays, efforts have focused on alternative therapeutic immunization approaches, although these still need to be further optimized. Using an immunomodulator capable of restoring immune function in the context of infection, thereby boosting cell‐mediated and humoral responses, could be critical in effectively improving current therapeutic approaches. Adenosine deaminase, a protein with a pivotal role in T‐cell co‐stimulation, has been shown to robustly enhance specific T‐cell responses against HIV in vitro. Although its role in humoral responses has not yet been assessed, genetic defects in this enzyme are associated with impaired cellular and humoral responses. Importantly, this molecule is already commercially available pharmaceutically and, therefore, it fulfils all the requirements to be assayed as an anti‐HIV vaccine adjuvant.

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Rapid assessment of drug-related HIV risk among men who have sex with men in three South African cities

Cited by 64 publications

References 17 publications

Socio-demographic characteristics and sexual health related attitudes and practices of men having sex with men in central and southern Malawi

Socio-demographic characteristics and sexual health related attitudes and practices of men having sex with men in central and southern Malawi

Factors influencing HIV infection in men who have sex with men in China

An old enzyme for current needs: adenosine deaminase and a dendritic cell vaccine for HIV

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