Factors influencing HIV infection in men who have sex with men in China

Xu, Hang; Jia, Manhong; Xiao, Min; Zhang, Renzhong; Yu, Chun-Jie; Wang, Jue; Li, Youfang; Pan, Songfeng; Lu, Li-Cheng

doi:10.1038/aja.2013.51

Cited by 14 publications

(18 citation statements)

References 23 publications

(22 reference statements)

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“…Compared to MSM without commercial sex, the prevalence of HIV/STIs is usually higher among MSM sex workers [11, 16, 17]. Our findings also demonstrated this trend that MSM with commercial sex had higher HIV/STIs prevalence than those without commercial sex, as suggested in other study [18], though the prevalence of HIV, syphilis and HSV-2 was not significant different among MSM-selling, MSM-buying and NC-MSM.…”

Section: Discussionsupporting

confidence: 85%

Commercial sex and risk of HIV, syphilis, and herpes simplex virus-2 among men who have sex with men in six Chinese cities

Zheng

et al. 2016

BMC Infect Dis

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Background: Men who have sex with men (MSM) are at high risk of HIV and sexually transmitted infections (STIs) in China and globally. Engaging in commercial sex put them at even greater risk. This study estimated the prevalence of HIV/STIs among three subgroups of MSM: MSM who sold sex (MSM-selling), MSM who bought sex (MSM-buying), and non-commercial MSM (NC-MSM) and evaluated the relationship between commercial sex and HIV/STIs. Methods: We conducted a cross-sectional survey among MSM in six Chinese cities (Shenyang, Ji'nan, Changsha, Zhengzhou, Nanjing, and Kunming) from 2012 to 2013. Data on socio-demographics and sexual behaviors were collected. Serological tests were conducted to detect HIV, syphilis, and human simplex virus type 2 (HSV-2). Results: Of 3717 MSM, 6.8% were engaged in commercial sex. The overall prevalence of HIV, syphilis and HSV-2 infections was 11.1, 8.8 and 12.1%, respectively. MSM-selling had higher prevalence of HIV (13.4%), syphilis (12.1%) and HSV-2 (17.9%) than NC-MSM (10.9, 8.7 and 11.9% for HIV, syphilis and HSV-2, respectively), though the differences are not statistically significant. Among MSM-selling, HIV prevalence was significantly higher for those who found sex partners via Internet than those did not (19.4% vs. 8.1%, P = 0.04). Compared to NC-MSM, MSM-selling were more likely to use recreation drugs (59.3% vs. 26.3%), have unprotected anal intercourse (77.9% vs. 61.7%), and have ≥10 male sex partners (46.2% vs. 6.2%) in the past 6 months (each P < 0.05). Conclusions: All three subgroups of MSM in six large Chinese cities have high prevalence of HIV/STIs. Those who sell sex only have a particularly high risk of acquiring and transmitting disease, and therefore, they should be considered as a priority group in HIV/STIs surveillance and intervention programs.

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Section: Discussionsupporting

confidence: 85%

Commercial sex and risk of HIV, syphilis, and herpes simplex virus-2 among men who have sex with men in six Chinese cities

Zheng

et al. 2016

BMC Infect Dis

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“…In this study, condom use was protective for HIV; however, only “frequent condom use” was a significant protective factor. The role of condom use in protecting MSM from HIV infection has been shown in a number of studies [18, 30–32]. However, consistent condom use in our study was only 43.5 %, which is similar to that in other provinces in Vietnam [4], suggesting a need to expand and strengthen condom programmes for MSM in Vietnam.…”

Section: Discussioncontrasting

confidence: 44%

Sociodemographic Factors, Sexual Behaviors, and Alcohol and Recreational Drug Use Associated with HIV Among Men Who Have Sex with Men in Southern Vietnam

et al. 2016

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A total of 2768 MSM participated in a survey in southern Vietnam. Univariate and multivariate logistic regression analyses were performed to determine predictors of HIV infection. The prevalence of HIV among MSM was 2.6 %. HIV infection was more likely in MSM who were older, had a religion, had engaged in anal sex with a foreigner in the past 12 months, previously or currently used recreational drugs, perceived themselves as likely or very likely to be infected with HIV, and/or were syphilis seropositive. MSM who had ever married, were exclusively or frequently receptive, sometimes consumed alcohol before sex, and/or frequently used condoms during anal sex in the past 3 months were less likely to be infected with HIV. Recreational drug use is strongly associated with HIV infection among MSM in southern Vietnam. HIV interventions among MSM should incorporate health promotion, condom promotion, harm reduction, sexually transmitted infection treatment, and address risk behaviors.

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“…Cumulative meta-analysis Men (n) Kreiss et al (1993) 73 Kumta et al (2002) 81 Tabet et al (2002) 86 Golden et al (2003) 67 Buchbinder et al (2005) 63 Millett et al (2007) 78 Millett et al (2007) 78 Reisen et al (2007) 83 Mor et al (2007) 79 Sanchez et al (2009) 84 Templeton et al (2009) 87 Gust et al (2010) 69 McDaid et al (2010) 77 Jameson et al (2010) 71 Jozkowski et al (2010) 72 Zou et al (2010) 91 Sánchez et al (2011) 85 Chen et al (2011) 64 Lane et al (2011) 76 Oster et al (2011) 80 Thornton et al (2011) 89 Lan et al (2011) 66 Gao et al (2012) 19 Clatts et al (2012) 13 Schneider et al (2012) 18 Yunihastuti et al (2012) 90 Hladik et al (2012) 14 Koblin et al (2013) 24 Sanders et al (2013) 26 Griensven et al (2013) 22 Xu et al (2013) 28 Doerner et al (2013) 21 Zhou et al (2013) 30 van Aar et al (2013) 27 Pando et al (2013) 25 Zeng et al (2014) 32 Sullivan et al (2015) 38 Solomon et al (2015) 37 Liu et al (2015) 34 Sathane et al (2016) 42 Sathane et al (2016) 42 Xu et al (2016) 45 Wang et al (2016) …”

Section: Meta-analysismentioning

confidence: 99%

Circumcision to prevent HIV and other sexually transmitted infections in men who have sex with men: a systematic review and meta-analysis of global data

Yuan

Fitzpatrick

et al. 2019

The Lancet Global Health

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Background Men who have sex with men (MSM) are disproportionately affected by HIV and other sexually transmitted infections (STIs) worldwide. Previous reviews investigating the role of circumcision in preventing HIV and other STIs among MSM were inconclusive. Many new studies have emerged in the past decade. To inform global prevention strategies for HIV and other STIs among MSM, we reviewed all available evidence on the associations between circumcision and HIV and other STIs among MSM.Methods In this systematic review and meta-analysis, we searched PubMed, Web of Science, BioMed Central, Scopus, ResearchGate, Cochrane Library, Embase, PsycINFO, Google Scholar, and websites of international HIV and STI conferences for studies published before March 8, 2018. Interventional or observational studies containing original quantitative data describing associations between circumcision and incident or prevalent infection of HIV and other STIs among MSM were included. Studies were excluded if MSM could not be distinguished from men who have sex with women only. We calculated pooled odds ratios (ORs) and their 95% CIs using random-effect models. We assessed risk of bias using the Newcastle-Ottawa scale. (0·99, 0·90-1·09; k=20; I²=40%). Circumcision was associated with reduced odds of herpes simplex virus (HSV) infection among MSM overall (0·84, 0·75-0·95; k=5; I²=0%) and penile human papillomavirus (HPV) infection among HIV-infected MSM (0·71, 0·51-0·99; k=3; I²=0%). Findings We identified 62 observational studies including 119 248 MSM. Circumcision was associated with 23% reduced odds of HIV infection among MSM overall (OR 0·77, 95% CI 0·67-0·89; number of estimates [k]=45; heterogeneity I²=77%). Circumcision was protective against HIV infection among MSM in countries of low and middle income (0·58, 0·41-0·83; k=23; I²=77%) but not among MSM in high-income countries Interpretation We found evidence that circumcision is likely to protect MSM from HIV infection, particularly in countries of low and middle income. Circumcision might also protect MSM from HSV and penile HPV infection. MSM should be included in campaigns promoting circumcision among men in countries of low and middle income.In view of the substantial proportion of MSM in countries of low and middle income who also have sex with women, well designed longitudinal studies differentiating MSM only and bisexual men are needed to clarify the effect of circumcision on male-to-male transmission of HIV and other STIs.

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Factors influencing HIV infection in men who have sex with men in China

Cited by 14 publications

References 23 publications

Commercial sex and risk of HIV, syphilis, and herpes simplex virus-2 among men who have sex with men in six Chinese cities

Commercial sex and risk of HIV, syphilis, and herpes simplex virus-2 among men who have sex with men in six Chinese cities

Sociodemographic Factors, Sexual Behaviors, and Alcohol and Recreational Drug Use Associated with HIV Among Men Who Have Sex with Men in Southern Vietnam

Circumcision to prevent HIV and other sexually transmitted infections in men who have sex with men: a systematic review and meta-analysis of global data

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