Rapid and simultaneous determination of tetracycline and cefixime antibiotics by mean of gold nanoparticles-screen printed gold electrode and chemometrics tools

Asadollahi-Baboli, M.; Mani-Varnosfaderani, Ahmad

doi:10.1016/j.measurement.2013.08.029

Cited by 62 publications

(23 citation statements)

References 14 publications

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“…Platinum is widely used in industry as catalyst and despite its high cost, it presents high stability and electrical conductivity, which makes it attractive for the development of sensors [22,23]. Most electrochemical sensing platforms containing nanoparticles combined with other materials for tetracycline detection are based on gold nanoparticles [24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Construction of an electrochemical sensing platform based on platinum nanoparticles supported on carbon for tetracycline determination

Kushikawa

Silva

Angelo

et al. 2016

Sensors and Actuators B: Chemical

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a b s t r a c tIn this paper, we report the construction of an electrochemical sensing platform based on platinum nanoparticles supported on carbon (PtNPs/C) for the determination of the antibiotic tetracycline (TTC). Initially, the PtNPs/C was synthesized and characterized by powder X-ray diffraction spectroscopy and transmission electron microscopy. The effect of experimental parameters on the electrochemical behavior of the PtNPs/C coated glassy carbon electrode (PtNPs/C/GCE), including the amount of PtNPs and electroactive area, scan rate and pH, were evaluated. The electrooxidation of TTC on the PtNPs/C/GCE was investigated by cyclic voltammetry and differential pulse voltammetry, with the determination of TTC electrooxidation mechanism. Under optimum experimental conditions, the linear calibration range, detection limit, quantification and sensitivity of the PtNPs/C/GCE were 9.99-44.01 mol L −1 , 4.28 mol L −1 , 14.3 mol L −1 and 3.32 A L mol −1 cm −2 , respectively. Finally, the proposed electrochemical sensing platform was successfully applied to determine low TTC concentrations in urine samples, suggesting its great applicability in clinical analysis and quality control.

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Section: Introductionmentioning

confidence: 99%

Construction of an electrochemical sensing platform based on platinum nanoparticles supported on carbon for tetracycline determination

Kushikawa

Silva

Angelo

et al. 2016

Sensors and Actuators B: Chemical

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“…12 The electrooxidation behavior of CEF on a glassy carbon electrode was shown and detection of CEF in real samples was established by Golcu et al 13 Voltammetric determination of CEF on multiwalled carbon nanotubes deco- self-assembly monolayers-modified gold nanoparticles utilizing a screen-printed gold electrode in order to determine CEF in biological fluids. 16 To the best of our knowledge, there are no articles about voltammetric or amperometric determination of CEF utilizing ionic liquids with a bismuth film-modified electrode, which is the main goal of this study.…”

Section: Introductionmentioning

confidence: 99%

An ionic liquid/bismuth lm-modi ed sensor for the electrochemical detection of ce xime

2018

Turk J Chem

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A highly sensitive and simple method based on an ionic liquid/ex situ bismuth film-modified single-use pencil graphite electrode (IL/Bi/PGE) was offered for the electrochemical detection of cefixime (CEF) for the first time. The synergistic effects of the ionic liquid and bismuth film combination as the surface modifier remarkably improved the electrochemical response of the modified sensor. Anodic oxidation of CEF was observed at 0.9 V vs. Ag/AgCl/3 M KCl as one well-defined irreversible oxidation peak. Under optimum experimental conditions, the IL/Bi/PGE exhibited a linear relationship for CEF concentrations in the range of 0.005-0.5 µ M (R 2 = 0.996) with a detection limit as 0.22 nM with square wave voltammetry. The IL/Bi/PGE had excellent sensor properties to electrochemically detect CEF when compared to the literature. This method was successfully applied for practical use with pharmaceutical samples by standard addition method with high accuracy. These results showed that this simple analytical method can find potential application in the clinical field instead of highly expensive and time-consuming processes.

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“…Therefore, the analysis of voltammetric data for these signals is difficult and direct determination of analytes with overlapping voltammogram peaks is impossible. So recently, chemometric methods such as the multivariate curve resolution and partial least squares (MCR-PLS) [25][26][27] have been applied for the analysis of binary and multi components with overlapping results. The main advantages of these techniques are the higher speed processing data concerning the values of concentrations and voltammograms of compounds with strong overlapping.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical and Chemometric Determination of Dorzolamide and Timolol in Eye Drops Using Modified Multiwall Carbon Nanotube Electrode

Hendawy

Elwy

Fekry

2017

Int J Pharm Pharm Sci

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Objective: This work is focused on the construction of simple and sensitive electrochemical sensor for quantitative determination of dorzolamide (DOR) and timolol maleate (TIM). This method is based on the incorporation of multiwall carbon nanotubes (MWCNT) into the carbon paste electrode which improve the characteristics of the electrode. Methods:The electrochemical response of modified electrode was based on voltammetric oxidation, using cyclic voltammetry (CV) and impedance spectroscopy (EIS). The structural morphology of the surface modified electrode was characterized by scanning electron microscope (SEM). Quantitative analysis for each of the two compounds in a mixture has been examined by using of chemometric tools for resolving overlapping signals. The prediction performance of the chemometric method was analyzed by principal component regression (PCR) and partial least square (PLS).Results: Fractional factorial design was constructed from set of synthetic mixtures of two drugs in concentration ranges of 0.05 to 1.6µg/ml for DOR and 1.5-20 µg/ml for TIM. Under optimum experimental conditions, DOR and TIM gave rectilinear response over the concentration range of 0.072-1.88 µg/ml and 1.16-20.84 µg/ml, respectively. The limit of detection (LOD) was found to be 0.098 and 1.025 µg/ml, for DOR and TIM, respectively. It found that the % of relative prediction error (RPE) was acceptable and satisfactory. Conclusion:In these work, for the first time, a new voltammetric simultaneous method developed for a rapid and efficient determination of DOR and TIM from eye dropper sample at nano modified electrode with satisfactory results. These results indicate that MWCNT holds great promise in practical application.

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Rapid and simultaneous determination of tetracycline and cefixime antibiotics by mean of gold nanoparticles-screen printed gold electrode and chemometrics tools

Cited by 62 publications

References 14 publications

Construction of an electrochemical sensing platform based on platinum nanoparticles supported on carbon for tetracycline determination

Construction of an electrochemical sensing platform based on platinum nanoparticles supported on carbon for tetracycline determination

An ionic liquid/bismuth lm-modi ed sensor for the electrochemical detection of ce xime

Electrochemical and Chemometric Determination of Dorzolamide and Timolol in Eye Drops Using Modified Multiwall Carbon Nanotube Electrode

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