Rapid and simple detection of Tamiflu-resistant influenza virus: Development of oseltamivir derivative-based lateral flow biosensor for point-of-care (POC) diagnostics

Hwang, Seul Gee; Ha, Kab; Guk, Kyeonghye; Lee, Do Kyung; Eom, Gayoung; Song, Sinae; Kang, Taejoon; Park, Hwangseo; Jung, Juyeon; Lim, Eun‐Kyung

doi:10.1038/s41598-018-31311-x

Cited by 44 publications

(39 citation statements)

References 74 publications

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“…Although those AIV biosensors required more tests and optimization processes, the introduction of nanobio hybrid to biosensors combined with the nanofabrication of electrode array integrated with a printed circuit board for miniaturization is required for the product commercialization. Also, the real-time monitoring of AIV technique should be considered to determine suspected virus infection samples [94,95,96]. In addition, nanobio hybrid material can be used in wearable biosensor platforms, which is one of the future trends in biosensors due to simple usage and long-term monitoring capability.…”

Section: Discussionmentioning

confidence: 99%

Recent Advances in AIV Biosensors Composed of Nanobio Hybrid Material

et al. 2018

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Since the beginning of the 2000s, globalization has accelerated because of the development of transportation systems that allow for human and material exchanges throughout the world. However, this globalization has brought with it the rise of various pathogenic viral agents, such as Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), Zika virus, and Dengue virus. In particular, avian influenza virus (AIV) is highly infectious and causes economic, health, ethnical, and social problems to human beings, which has necessitated the development of an ultrasensitive and selective rapid-detection system of AIV. To prevent the damage associated with the spread of AIV, early detection and adequate treatment of AIV is key. There are traditional techniques that have been used to detect AIV in chickens, ducks, humans, and other living organisms. However, the development of a technique that allows for the more rapid diagnosis of AIV is still necessary. To achieve this goal, the present article reviews the use of an AIV biosensor employing nanobio hybrid materials to enhance the sensitivity and selectivity of the technique while also reducing the detection time and high-throughput process time. This review mainly focused on four techniques: the electrochemical detection system, electrical detection method, optical detection methods based on localized surface plasmon resonance, and fluorescence.

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Section: Discussionmentioning

confidence: 99%

Recent Advances in AIV Biosensors Composed of Nanobio Hybrid Material

et al. 2018

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“…Hwang et al. developed a lateral flow biosensor for the detection of Tamiflu-resistant influenza virus, specifically the mutated neuraminidase on the surface of the virus [ 79 ]. Both assays reduce the time even further from the abbreviated ELISA.…”

Section: Assay Methodologies Under Investigationmentioning

confidence: 99%

A critical review of point-of-care diagnostic technologies to combat viral pandemics

Everitt

Tillery

David

et al. 2021

Analytica Chimica Acta

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The COVID-19 global pandemic of 2019–2020 pointedly revealed the lack of diagnostic solutions that are able to keep pace with the rapid spread of the virus. Despite the promise of decades of lab-on-a-chip research, no commercial products were available to deliver rapid results or enable testing in the field at the onset of the pandemic. In this critical review, we assess the current state of progress on the development of point-of-care technologies for the diagnosis of viral diseases that cause pandemics. While many previous reviews have reported on progress in various lab-on-a-chip technologies, here we address the literature from the perspective of the testing needs of a rapidly expanding pandemic. First, we recommend a set of requirements to heed when designing point-of-care diagnostic technologies to address the testing needs of a pandemic. We then review the current state of assay technologies with a focus on isothermal amplification and lateral-flow immunoassays. Though there is much progress on assay development, we argue that the largest roadblock to deployment exists in sample preparation. We summarize current approaches to automate sample preparation and discuss both the progress and shortcomings of these developments. Finally, we provide our recommendations to the field of specific challenges to address in order to prepare for the next pandemic.

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“…In the presence of Tamiflu-resistant virus, the OHT-AuNPs will change their color from red to purple because of AuNP aggregation caused by strong interactions between OHT and neuraminidase (NA) on the surface of the Tamiflu-resistant virus. The color change allows determination of the Tamiflu-resistant virus with the naked eye at a limit of 10 4 PFU/mL, thus supporting the selection of appropriate treatments using point-of-care diagnostics [141].…”

Section: Lab-on-chip Based On Aunpmentioning

confidence: 97%

“…Similar lateral flow device is developed for detection of Tamifluresistant virus, which is based on the fact that oseltamivir hexylthiol (OHT) has higher binding affinity for Tamiflu-resistant virus than Tamiflususceptible virus [141]. AuNPs modified with OHT are used as nanoprobes for Tamiflu-resistant virus detection.…”

Section: Lab-on-chip Based On Aunpmentioning

confidence: 99%

Colorimetric biosensors for point-of-care virus detections

Zhao

Wong

Zheng

et al. 2020

Materials Science for Energy Technologies

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a b s t r a c tColorimetric biosensors can be used to detect a particular analyte through color changes easily by naked eyes or simple portable optical detectors for quantitative measurement. Thus, it is highly attractive for point-of-care detections of harmful viruses to prevent potential pandemic outbreak, as antiviral medication must be administered in a timely fashion. This review paper summaries existing and emerging techniques that can be employed to detect viruses through colorimetric assay design with detailed discussion of their sensing principles, performances as well as pros and cons, with an aim to provide guideline on the selection of suitable colorimetric biosensors for detecting different species of viruses. Among the colorimetric methods for virus detections, loop-mediated isothermal amplification (LAMP) method is more favourable for its faster detection, high efficiency, cheaper cost, and more reliable with high reproducible assay results. Nanoparticle-based colorimetric biosensors, on the other hand, are most suitable to be fabricated into lateral flow or lab-on-a-chip devices, and can be coupled with LAMP or portable PCR systems for highly sensitive on-site detection of viruses, which is very critical for early diagnosis of virus infections and to prevent outbreak in a swift and controlled manner.

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Rapid and simple detection of Tamiflu-resistant influenza virus: Development of oseltamivir derivative-based lateral flow biosensor for point-of-care (POC) diagnostics

Cited by 44 publications

References 74 publications

Recent Advances in AIV Biosensors Composed of Nanobio Hybrid Material

Recent Advances in AIV Biosensors Composed of Nanobio Hybrid Material

A critical review of point-of-care diagnostic technologies to combat viral pandemics

Colorimetric biosensors for point-of-care virus detections

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