Rapid and Sensitive Determination of Five Amine Biomarkers in Plasma Samples from Stroke Patients by MEKC with Precolumn Derivatization

Peng, Long; Wang, Na; Si, Hui; Wu, Chen; Qiao, Yingjie

doi:10.1007/s10337-012-2300-y

Cited by 2 publications

(1 citation statement)

References 15 publications

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“…MEKC-LIF was used to simultaneously detect five amine biomarkers, homocysteine (Hcy), excitatory amino acid (EAA) neurotransmitters principally including glutamic acid (Glu), polyamines such as putrescine (Put), spermine (Spm) and spermidine (Spd). From plasma samples of neuro-imaged IS patients, LODs of 0.2-2.1 nM (S/N = 3) were achieved, which is approximately 800fold lower compared with the usual concentration levels of these analytes in human plasma under normal or pathophysiological conditions [134].…”

Section: Miscellaneous Detection Approachesmentioning

confidence: 92%

Current and Future Bioanalytical Approaches for Stroke Assessment

et al. 2015

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Efforts are underway to develop novel platforms for stroke diagnosis to meet the criteria for effective treatment within the narrow time window mandated by the FDA-approved therapeutic (<3 h). Blood-based biomarkers could be used for rapid stroke diagnosis and coupled with new analytical tools, could serve as an attractive platform for managing stroke-related diseases. In this review, we will discuss the physiological processes associated with stroke and current diagnostic tools as well as their associated shortcomings. We will then review information on blood-based biomarkers and various detection technologies. In particular, point of care testing that permits small blood volumes required for the analysis and rapid turn-around time measurements of multiple markers will be presented.

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Section: Miscellaneous Detection Approachesmentioning

confidence: 92%