Rapid and repeatable fabrication of high A/R silk fibroin microneedles using thermally-drawn micromolds

Lee, Ji Yong; Park, Seung Hyun; Seo, Il Ho; Lee, KangJu; Ryu, Wooseok

doi:10.1016/j.ejpb.2015.04.024

Cited by 66 publications

(33 citation statements)

References 41 publications

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“…50,52 Preparing degradable microneedles by postprocessing is an interesting alternative method that has been developed recently for overcoming the drawbacks mentioned above. [56][57][58][59][60][61][62][63][64][65] This approach combines the advantages of easiness for drug loading of dissolving microneedles during the preparation process and sustained release properties of biodegradable polymers. To prepare the microneedles, chemically modified water-soluble polymers were first used for the loading of drugs and vaccines.…”

Section: Degradable Microneedles Made Of Hydrophobic Polymersmentioning

confidence: 99%

“…Studies have shown that the crosslinked or crystallized microneedles can significantly improve the stiffness of microneedles and extend the release time of the payloads. The matrices used for this type of microneedles include crosslinked methacrylated hyaluronic acid (MeHA), 57,61,[63][64][65] crosslinked PVA, 66 genipin-crosslinked gelatin, 58 crystallized silk fibroin, 59,60 and crosslinked alginate. 67 Researchers from Gu et al's group fabricated crosslinked MeHA microneedles and applied them for the delivery of checkpoint inhibitors, tumor lysates, and insulin (►Fig.…”

Section: Degradable Microneedles Made Of Hydrophobic Polymersmentioning

confidence: 99%

“…60 Jiyong et al treated silk-fibroin-based microneedles with methanol, and found that the exposure time to methanol can be used to control the drug release rate. 59…”

Section: Degradable Microneedles Made Of Hydrophobic Polymersmentioning

confidence: 99%

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Current Advances in Sustained Release Microneedles

Sun

2020

Pharmaceutical Fronts

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AbstractMicroneedles have been extensively investigated for intradermal delivery of drugs and vaccines due to advantages including high skin delivery efficiency, improved patient compliance, and potential for self-administration. However, traditional microneedles cannot regulate the release kinetics of payloads, limiting therapeutic utility of the biotherapeutics. Recently, several types of microneedles with sustained release properties, including slow-dissolving microneedles made of hydrophilic polymers, degradable microneedles made of hydrophobic polymers, and bioresponsive microneedles made of bioresponsive polymers, have been developed and investigated for intradermal delivery of the biotherapeutics, aiming for improving their therapeutic potency, reducing side effects and administration frequency, and further improving patient compliance. In this review, we introduced different types of microneedles that have been designed for sustained release of the payloads, summarized various applications of these microneedles, and discussed the future prospects of this technology.

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Section: Degradable Microneedles Made Of Hydrophobic Polymersmentioning

confidence: 99%

Section: Degradable Microneedles Made Of Hydrophobic Polymersmentioning

confidence: 99%

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Current Advances in Sustained Release Microneedles

Sun

2020

Pharmaceutical Fronts

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“…This natural polymer is approved by FDA for human use in medical devices such as wound dressings and sutures, and GMP grade silk fibroin is available from Vaxess Technologies. Significant progress has been made by Vaxess in developing a consistent, repeatable manufacturing process for silk fibroin microneedles [72]. Additionally, several protein immobilization strategies can be used with this polymer including adsorption, covalent bonding, entrapment, and encapsulation [73].…”

Section: Natural Polymeric Microneedlesmentioning

confidence: 99%

Enabling Vaccine Delivery Platforms and Adjuvants for Malaria

Noe¹,

Kotraiah²,

Gutierrez³

2016

Current Topics in Malaria

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Enabling vaccine delivery platforms and adjuvants with promising attributes for malaria vaccine development are reviewed within the framework of accessibility, efficacy, clinical status, cost, and cold-chain considerations. An emphasis is placed on commercially available platforms and adjuvants including virus-like particle, nanoparticle, microneedle, and mRNA vaccine delivery platforms as well as lipid vesicle, microparticle, and emulsion-based adjuvants. Strategies for addressing complications of vaccine delivery in endemic regions due to concatenate vaccination and infection, and parasite immune avoidance mechanisms are presented. Additionally, recent findings regarding how malaria infection triggers inflammatory pathways and T cell exhaustion along with negative impacts to the development of effective memory responses are described in a context relevant to vaccine development.

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“…In another study, Lee et al fabricated silk fibroin microneedles using thermally drawn micromolds with methanol treatment. The results showed that methanol exposure time could effectively control the drug release rate from silk fibroin microneedles (Lee et al, ).…”

Section: Preparation Of Silk Fibroin Carriers For Controlled Releasementioning

confidence: 99%

Preparation of silk fibroin carriers for controlled release

Liu

Fan

2015

Microscopy Res & Technique

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Silk fibroin provides a new option for controlled release systems as a result of its excellent biodegradability, biocompatibility, and mechanical properties. As the core material, silk fibroin can be designed and widely used in drug/gene delivery, regenerative medicine, and other biomedical fields. This review focuses on the preparation methods, loading molecules, and applications of silk fibroin-based controlled release systems including microspheres, microcapsules, films, microparticles, microneedles, liposomes, and hydrogels. These systems provide numerous advantages such as high encapsulation efficiency, avoiding loss of bioactivity and maintaining desirable range without peaks and valleys in comparison to the traditional administration approaches. Microsc. Res. Tech. 80:312-320, 2017. © 2015 Wiley Periodicals, Inc.

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Rapid and repeatable fabrication of high A/R silk fibroin microneedles using thermally-drawn micromolds

Cited by 66 publications

References 41 publications

Current Advances in Sustained Release Microneedles

Current Advances in Sustained Release Microneedles

Enabling Vaccine Delivery Platforms and Adjuvants for Malaria

Preparation of silk fibroin carriers for controlled release

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