Rapid and Effective Speciation Analysis of Arsenic Compounds in Human Urine using Anion‐Exchange Columns in HPLC‐ICP‐MS

Suzuki, Yoshihiro; Shimoda, Yasuyo; Endo, Yuichi; Hata, Akihisa; Yamanaka, Kazuhiro; Endo, Ginji

doi:10.1539/joh.m9003

Cited by 25 publications

(31 citation statements)

References 12 publications

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“…T-As in urine of the first sample was 1607.2 µg/l but Ga was not detected (< 0.14 µg/l). The AsV, AsIII, and MMA concentrations were 7, 41, and 51 times higher than those of reference values of 1.7, 5.4, and 6.2 µg/l obtained in our previous study (Suzuki et al, 2009), respectively. After discharge, he took a 10-day holiday and moved to a factory with no arsine so his As concentrations had decreased to close to the reference levels by 68 days after exposure.…”

Section: Resultscontrasting

confidence: 68%

“…Only AsBe was detected in the serum 110 days later. AsBe is frequently ingested by humans via the consumption of seafood and excreted unchanged in urine (Le et al, 1994), therefore, the concentration is the highest among As compounds in the urine of ordinary Japanese (Suzuki et al, 2009). On the contrary, the concentration of AsBe in the serum and urine of the patient were very low during admission and at the time of discharge because he had IVH during hospitalization while fasting.…”

Section: Resultsmentioning

confidence: 99%

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Speciation analysis of arsenic compounds in the serum and urine of a patient with acute arsine poisoning

Yamanaka

Yamano

Yoshimura

et al. 2013

E3S Web of Conferences

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Abstract. Arsine is one of the most potent hemolytic agents. It is important to clarify arsine metabolism as well as its chemical interactions with biological components. The aim of the present study was to clarify arsine metabolism by arsenic speciation analysis in serum and urine from an acute poisoning patient with hematuria, anemia, and renal and liver dysfunction. Speciation analysis of arsenics in serum and urine was performed using HPLC-ICP-MS. The total arsenic (T-As) concentration in serum was 244.8 µg/l at admission and 97.1 µg/l at discharge. In the speciation analysis, four kinds of As compounds derived from arsine metabolism were detected in serum and urine. The concentration of arsenite (AsIII), arsenate (AsV), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) in serum at admission were 45.8, 5.2, 17.9 and 9.3 µg/l, respectively.The concentrations of AsIII, AsV, and MMA decreased with biological half time (BHT) of 30.1, 43.0, and 96.3 h, respectively. Only DMA was increased at discharge. The urinary AsIII, AsV, MMA and DMA concentrations were 223.0, 12.1, 317.5 and 1053.5 µg/l at discharge, and decreased with BHT of 15.1, 20.8, 14.7, and 16.0 d, respectively. The results indicate that arsine was quickly metabolized to AsIII and subsequently up to DMA, with the result that the toxic effects of inorganic arsenic were added to those of arsine toxicity.

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Section: Resultscontrasting

confidence: 68%

Section: Resultsmentioning

confidence: 99%

Speciation analysis of arsenic compounds in the serum and urine of a patient with acute arsine poisoning

Yamanaka

Yamano

Yoshimura

et al. 2013

E3S Web of Conferences

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“…Currently, high-performance liquid chromatography with inductively coupled plasma mass spectrometry (HPLC-ICP-MS) is the mainstay of speciation analyses of arsenic in biological samples because of its sensitivity and effectiveness 5,7) . However, it is a remarkably expensive and complicated system, and hence it is not commonly used in many laboratories.…”

Section: Development Of An Analyticalmentioning

confidence: 99%

Development of an Analytical Method for the Determination of Arsenic in Urine by Gas Chromatography‐mass Spectrometry for Biological Monitoring of Exposure to Inorganic Arsenic

Takeuchi

Namera

Kawasumi

et al. 2012

Journal of Occupational Health

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Interday accuracy and precision were 81.3−100.0% and 0.8−9.9%, respectively. The analytical values of SRM 2669 obtained by the proposed method were sufficiently accurate. Conclusions: The proposed method overcame the disadvantages of high-performance liquid chromatography with inductively coupled plasma mass spectrometry. It was a robust, selective and cost-effective method suitable for routine analyses and could be useful for the biological monitoring of occupational exposure to inorganic arsenic. (J Occup Health 2012; 54: 434-440)

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“…On HD 2, the total concentration of inorganic arsenic and methylated metabolites thereof (92.8 µ g As/l) was above the 35 µ g As/l set as the ACGIH BEI. In addition, the sum of the concentration of inorganic arsenic and MMA is considered to be a good biological indicator of inorganic exposure among people generally taking seafoods 11) . The sum (15.3 µ g As/l) of the AsIII and MMA concentration of HD 2 was higher than 95th percentile of the general population (12.6 µ g/l), but those on HD7 and HD12 were almost the 75th percentile 11) .…”

Section: Discussionmentioning

confidence: 99%

“…In addition, the sum of the concentration of inorganic arsenic and MMA is considered to be a good biological indicator of inorganic exposure among people generally taking seafoods 11) . The sum (15.3 µ g As/l) of the AsIII and MMA concentration of HD 2 was higher than 95th percentile of the general population (12.6 µ g/l), but those on HD7 and HD12 were almost the 75th percentile 11) . In particular, an MMA level higher than that of inorganic arsenic indicates inorganic exposure based on inorganic arsenic metabolism 12) .…”

Section: Discussionmentioning

confidence: 99%

A Guillain‐Barré Syndrome‐like Neuropathy Associated with Arsenic Exposure

Kim

Takeuchi

Kawasumi

et al. 2012

Journal of Occupational Health

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Republic of Korea-Objectives:We report on a patient presenting with an isolated polyneuropathy mimicking Guillain-Barré syndrome (GBS) associated with arsenic exposure. Case: A 43-year-old man visited our emergency room complaining of progressive quadriparesis over the prior 5 days. His clinical course with laboratory data was typical of GBS. However, because of his recent use of herbal medication, we screened for the presence of several heavy metals. Serial analyses of urinary inorganic arsenic concentrations confirmed exposure to arsenic. He was diagnosed as arsenic neuropathy mimicking GBS without any systemic manifestation of arsenic intoxication. Conclusions: The present case study emphasizes the need to consider arsenic intoxication in patients presenting with acute demyelinating neuropathies and histories of herbal medication use. (J Occup Health 2012; 54: 344-347) Key words: Arsenic, Guillain-Barré syndrome, Peripheral neuropathy, SpeciesAcute arsenic intoxication is a rare cause of acute demyelinating polyneuropathy 1) . The earliest clinical features of acute, high-dose arsenic poisoning

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Rapid and Effective Speciation Analysis of Arsenic Compounds in Human Urine using Anion‐Exchange Columns in HPLC‐ICP‐MS

Cited by 25 publications

References 12 publications

Speciation analysis of arsenic compounds in the serum and urine of a patient with acute arsine poisoning

Speciation analysis of arsenic compounds in the serum and urine of a patient with acute arsine poisoning

Development of an Analytical Method for the Determination of Arsenic in Urine by Gas Chromatography‐mass Spectrometry for Biological Monitoring of Exposure to Inorganic Arsenic

A Guillain‐Barré Syndrome‐like Neuropathy Associated with Arsenic Exposure

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