“…Medical Research, London, N. W. 3 (Received 16 May 1962) The physiological changes which characterize acclimatization to heat have been frequently studied in the laboratory (Henschel, Taylor & Keys, 1943;Robinson, Turrell, Belding & Horvath, 1943;Horvath & Shelley, 1946;Eichna, Park, Nelson, Horvath & Palmes, 1950;Ladell, 1951;Bass, Kleeman, Quinn, Henschel & Hegnauer, 1955;Macpherson, 1960). The method used has been to mimic the natural situation with the subjects performing a carefully controlled work and rest routine for some hours each day in a controlled hot climate.…”