Rapid absorption of substances injected into the bone marrow

Tocantins, Leandro M.

doi:10.1016/0002-9343(51)90039-3

Cited by 13 publications

(22 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Dr. Tocantins, a professor of medicine who conducted a series of animal studies examining IO infusions, explored the concept of IO infusions further. After completing a number of rabbit studies examining various fluids, such as dextrose, blood, and saline, he went on to report the successful IO infusions in nine pediatric patients with "impossible" intravenous access (De Sá, Melo, Dantas, & Delfim, 2012;Drinker, Drinker, & Lund, 1922;Luck, Haines, & Mull, 2010;Tocantins, 1940;Tocantins, O'Neill, & Jones, 1941). With the development of intravenous catheters, the IO needle was replaced as the favored instrument for vascular access.…”

mentioning

confidence: 99%

Characteristics of Children Who Undergo Intraosseous Needle Placement

Reuter‐Rice

Patrick

Kantor³

et al. 2015

Advanced Emergency Nursing Journal

View full text Add to dashboard Cite

Intraosseous (IO) access is a standard of care for pediatric emergencies in the absence of conventional intravenous access. Intraosseous needles provide access for resuscitation fluids and medications and are often placed in the emergency department. However, there are no studies to date that describe the characteristics of pediatric IO needle recipients or their dispositions and outcomes. This study examined the characteristics and disposition of children following IO needle placement by prehospital and emergency room teams before being transported to a children's hospital. We conducted a retrospective descriptive analysis of pediatric patients who had an IO needle placed as a part of their transport care. Data was extracted from a Level 1 trauma tertiary care children's hospital transport database from 1993 to 2009. We measured diagnosis, insertion reason, insertion time (day vs. night shift), complications, and disposition of patients after IO needle placement. There were 143 eligible patients in the study; 65% were males. Mean patient's age was 1.2 years (range: 0.01-13 years). Intraosseous needles were placed most often for patients with cardiopulmonary compromise. Of the 143 patients transported, 53% (n = 76) were placed for no intravenous access and 34% (n = 49) were placed for nonperfusing rhythm. The majority of the IO needles were placed during the daytime (0700-1900 hr), and most patients experienced no complications (n = 67; 47%). However, of those who experienced a complication, 27% were due to infiltration of the IO needle. Of those admitted to hospital, 58% (n = 83) were ultimately discharged home. Intraosseous access provides a safe and reliable method for rapidly achieving a route for administration of medications, fluids and blood products. It is a lifesaving measure with most IO needles successfully placed by referring facilities prior to transport, with few reported complications.

show abstract

mentioning

confidence: 99%

Characteristics of Children Who Undergo Intraosseous Needle Placement

Reuter‐Rice

Patrick

Kantor³

et al. 2015

Advanced Emergency Nursing Journal

View full text Add to dashboard Cite

show abstract

“…12,13 Later, Tocantins et al showed that substances injected intraosseously could reach the circulatory system and exert effects as rapidly as substances injected intravenously. 14,15 Intraosseous injection techniques began to be used in human medicine in emergency situations and in cases where IV access could not be obtained or maintained. [16][17][18][19] The use of IO injection techniques decreased when IV catheters were developed and became widely used.…”

Section: Discussionmentioning

confidence: 99%

Use of intraosseous blood for repeated hematologic and biochemical analyses in healthy pigs

Greco¹,

Talcott²,

LaRegina³

et al. 2001

ajvr

View full text Add to dashboard Cite

show abstract

“…Hungerford and Zizic have confirmed the work of Ficat and Arlet in finding that the stress test is more sensitive than baseline pressure measurement as a diagnostic tool for osteonecrosis (6). Because bone drains exclusively through venous outflow and infused solutions gain immediate vascular access (10,15), the stress test can be said to provide a qualitative evaluation of the outflow resistance in the intraosseous vascular bed.…”

mentioning

confidence: 88%

Hydraulic resistance: A measure of vascular outflow obstruction in osteonecrosis

Downey

Simkin

Lanzer

et al. 1988

Journal Orthopaedic Research

View full text Add to dashboard Cite

This study introduces hydraulic resistance (HR) as a new method to measure intraosseous vascular outflow resistance in the human proximal femur. HR is the standard measure of resistance to fluid flow in porous matrices and is derived from serial pressure/flow determinations. Eighteen hips were studied in 11 patients taken to surgery for core decompression therapy of presumable atraumatic osteonecrosis of the femoral head. HR was much higher in osteonecrotic (174 +/- 29 mm Hg min/ml, SE) than in normal human cadaveric femora (14 +/- 6) and was also higher in subcapital (253 +/- 39) than intertrochanteric sites (78 +/- 17). HR correlated highly with baseline intraosseous pressure (r = 0.74, p less than 0.001). HR testing is a simple, practical method which quantifies outflow obstruction of the intraosseous circulation. We believe this test will be helpful in the diagnosis of atraumatic osteonecrosis and in the understanding of its underlying pathophysiology.

show abstract

Rapid absorption of substances injected into the bone marrow

Cited by 13 publications

References 1 publication

Characteristics of Children Who Undergo Intraosseous Needle Placement

Characteristics of Children Who Undergo Intraosseous Needle Placement

Use of intraosseous blood for repeated hematologic and biochemical analyses in healthy pigs

Hydraulic resistance: A measure of vascular outflow obstruction in osteonecrosis

Contact Info

Product

Resources

About