Rapeseed oil ingestion and exacerbation of hypertension-related conditions in stroke prone spontaneously hypertensive rats

Naito, Yukiko; Nagata, Tomoko; Takano, Yuko; Nagatsu, Takashi; Ohara, Naoki

doi:10.1016/s0300-483x(03)00052-0

Cited by 32 publications

(36 citation statements)

References 24 publications

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“…In contrast, studies in the SHRSP rat model did show unfavourable effects on erythrocyte deformability (Ratnayake et al, 2000) and osmotic fragility (Naito et al, 2000(Naito et al, , 2003 after consumption of canola oil, which is abundant in plant sterols. A change in erythrocyte properties can be attributed to both a decrease in cholesterol levels of the red blood cell membrane as well as to an increase in plant sterol levels in the membrane (Naito et al, 2003).…”

Section: Discussionmentioning

confidence: 85%

“…Red blood cell deformability was, however, only decreased in the plant sterol group, whereas the lifespan was more shortened in the plant stanol-fed rats (Ratnayake et al, 2003). In the same rat model, osmotic fragility was also increased after canola oil consumption (Naito et al, 2000(Naito et al, , 2003. However, these effects were not found in hamsters fed plant stanol esters (Ebine et al, 2005).…”

Section: Discussionmentioning

confidence: 95%

“…A change in erythrocyte properties can be attributed to both a decrease in cholesterol levels of the red blood cell membrane as well as to an increase in plant sterol levels in the membrane (Naito et al, 2003). Indeed, an in vitro study showed that replacement of cholesterol in the erythrocyte membrane by various other sterols increased osmotic fragility (Bruckerdorfer et al, 1969).…”

Section: Discussionmentioning

confidence: 99%

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Plant sterol or stanol consumption does not affect erythrocyte osmotic fragility in patients on statin treatment

Jong

Mensink

2006

Eur J Clin Nutr

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Objective: To assess the effects of plant sterol or stanol ester consumption on their incorporation into erythrocytes and their effects on osmotic fragility of red blood cells. Design: Double-blind, randomized, placebo-controlled intervention trial. Subjects and intervention: Forty-one subjects on stable statin treatment -who already have increased serum plant sterol and stanol concentrations -first received for 4 weeks a control margarine. For the next 16 weeks, subjects were randomly assigned to one of three possible interventions. Eleven subjects continued with control margarine, 15 subjects with plant sterol ester enriched and 15 subjects with plant stanol ester-enriched margarine. Daily plant sterol or stanol intake was 2.5 g. Erythrocyte haemolysis was measured spectrophotometrically at five different saline concentrations. Results: Despite significant (P ¼ 0.004) increases of, respectively, 42 and 59% in cholesterol-standardized serum sitosterol and campesterol concentrations in the plant sterol group as compared to the control group, campesterol levels in the red blood cells did not change (P ¼ 0.196). Osmotic fragility did not change significantly (P ¼ 0.757) in the plant sterol and plant stanol groups as compared to the control group. Conclusion: We conclude that plant sterol and stanol ester consumption for 16 weeks does not change osmotic fragility of erythrocytes in statin-treated patients.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

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Plant sterol or stanol consumption does not affect erythrocyte osmotic fragility in patients on statin treatment

Jong

Mensink

2006

Eur J Clin Nutr

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“…The association between salt intake and hypertension is well known [32], which is evident in the present the study. Evidence indicates that canola oil intake has an effect on blood pressure in the SHRSP rat and its related strains [3,24]. However, the blood pressure in the canola oil groups was not consistently different from soybean oil.…”

Section: Discussionmentioning

confidence: 99%

The effect of short-term canola oil ingestion on oxidative stress in the vasculature of stroke-prone spontaneously hypertensive rats

et al. 2011

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BackgroundThis study aimed to determine if 25 days of canola oil intake in the absence of excess dietary salt or together with salt loading affects antioxidant and oxidative stress markers in the circulation. A further aim was to determine the mRNA expression of NADPH oxidase subunits and superoxide dismutase (SOD) isoforms in the aorta of stroke-prone spontaneously hypertensive (SHRSP) rats.MethodsMale SHRSP rats, were fed a defatted control diet containing 10% wt/wt soybean oil or a defatted treatment diet containing 10% wt/wt canola oil, and given tap water or water containing 1% NaCl. Blood was collected at the end of study for analysis of red blood cell (RBC) antioxidant enzymes, RBC and plasma malondialdehyde (MDA), plasma 8-isoprostane and plasma lipids. The aorta was removed and the mRNA expression of NOX2, p22phox, CuZn-SOD, Mn-SOD and EC-SOD were determined.ResultsIn the absence of salt, canola oil reduced RBC SOD and glutathione peroxidase, and increased total cholesterol and LDL cholesterol compared with soybean oil. RBC glutathione peroxidase activity was significantly lower in both the salt loaded groups compared to the soybean oil only group. In addition, RBC MDA and plasma HDL cholesterol were significantly higher in both the salt loaded groups compared to the no salt groups. Plasma MDA concentration was higher and LDL cholesterol concentration lower in the canola oil group loaded with salt compared to the canola oil group without salt. The mRNA expression of NADPH oxidase subunits and SOD isoforms were significantly reduced in the canola oil group with salt compared to canola oil group without salt.ConclusionIn conclusion, these results indicate that canola oil reduces antioxidant status and increases plasma lipids, which are risk factors for cardiovascular disease. However, canola oil in combination with salt intake increased MDA, a marker of lipid peroxidation and decreased NAPDH oxidase subunits and aortic SOD gene expression.

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“…To further complicate the field, some studies have also examined combinations including long-chain o-3 fatty acids. 8,10 Feeding a canola oil-rich diet can have adverse outcomes in some situations, including shortened life span, 13,14 reduced litter size and retardation of growth in stroke prone rats. 15 There is also evidence that indicates canola oil may result in less body weight gain than diets high in o-6 fatty acids.…”

Section: Introductionmentioning

confidence: 99%

Hypertension induced by ω-3 polyunsaturated fatty acid deficiency is alleviated by α-linolenic acid regardless of dietary source

et al. 2010

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X-3 polyunsaturated fatty acid deficiency, particularly during the prenatal period, can cause hypertension in later life. This study examined the effect of different sources of a-linolenic acid (canola oil or flaxseed oil) in the prevention of hypertension and other metabolic symptoms induced by an x-3 fatty acid-deficient diet. Dams were provided one of three experimental diets from 1 week before mating. Diets were either deficient (10% safflower oil-DEF) or sufficient (7% safflower oil+3% flaxseed oil-SUF-F; or 10% canola oil-SUF-C) in x-3 fatty acids. The male offspring were continued on the maternal diet from weaning for the duration of the study. Body weight, ingestive behaviors, blood pressure, body composition, metabolic rate, plasma leptin and brain fatty acids were all assessed. The DEF animals were hypertensive at 24 weeks of age compared with SUF-F or SUF-C animals; this was not evident at 12 weeks. These results suggest that different sources of ALA are effective in preventing hypertension related to x-3 fatty acid deficiency. However, there were other marked differences between the DEF and, in particular, the SUF-C phenotype including lowered body weight, adiposity, leptin and food intake in SUF-C animals. SUF-F animals also had lower, but less marked reductions in adiposity and leptin compared with DEF animals. The differences observed between DEF, SUF-F and SUF-C phenotypes indicate that body fat and leptin may be involved in x-3 fatty acid deficiency hypertension.

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Rapeseed oil ingestion and exacerbation of hypertension-related conditions in stroke prone spontaneously hypertensive rats

Cited by 32 publications

References 24 publications

Plant sterol or stanol consumption does not affect erythrocyte osmotic fragility in patients on statin treatment

Plant sterol or stanol consumption does not affect erythrocyte osmotic fragility in patients on statin treatment

The effect of short-term canola oil ingestion on oxidative stress in the vasculature of stroke-prone spontaneously hypertensive rats

Hypertension induced by ω-3 polyunsaturated fatty acid deficiency is alleviated by α-linolenic acid regardless of dietary source

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