A set of infinite binary sequences C ⊆ 2 N is negligible if there is no partial probabilistic algorithm that produces an element of this set with positive probability. The study of negligibility is of particular interest in the context of Π 0 1 classes. In this paper, we introduce the notion of depth for Π 0 1 classes, which is a stronger form of negligibility. Whereas a negligible Π 0 1 class C has the property that one cannot probabilistically compute a member of C with positive probability, a deep Π 0 1 class C has the property that one cannot probabilistically compute an initial segment of a member of C with high probability. That is, the probability of computing a length n initial segment of a deep Π 0 1 class converges to 0 effectively in n.We prove a number of basic results about depth, negligibility, and a variant of negligibility that we call tt-negligibility. We provide a number of examples of deep Π 0 1 classes that occur naturally in computability theory and algorithmic randomness. We also study deep classes in the context of mass problems, examine the relationship between deep classes and certain lowness notions in algorithmic randomness, and establish a relationship between members of deep classes and the amount of mutual information with Chaitin's Ω.1991 Mathematics Subject Classification. 03D32, 68Q30, 03D80. Key words and phrases. computability theory, algorithmic randomness, Π 0 1 classes, probabilistic computation.Both authors acknowledge the support of the John Templeton Foundation through the grant "Structure and Randomness in the Theory of Computation."Depth can be viewed as a strong form of negligibility. A deep Π 0 1 class C has the property that producing an initial segment of some member of C is in some sense maximally difficult: the probability of obtaining such an initial segment not only converges to 0 as we consider longer initial segments of members of C, but this convergence is fast, as we can effectively bound the rate of convergence. That initial segments of members of deep classes are so difficult to produce via probabilistic computation reflects the fact that members of deep classes are highly structured: initial segments of these sequences cannot be successfully produced by any combination of Turing machine and random oracle.Although the notion of depth is isolated for the first time in the present study, it is implicitly used in the work of both Levin [22] and Stephan [32]. In fact, in each of these papers one can extract a proof that the consistent completions of Peano arithmetic form a deep class, a result that we reprove in Section 7.The primary goals of this paper are (1) to prove a number of basic results about deep Π 0 1 classes, (2) to determine the exact relationship between negligibility and depth (and a related notion we call tt-negligibility), and (3) to provide a number of examples of deep Π 0 1 classes that occur naturally in computability theory and algorithmic randomness.The outline of this paper is as follows: In Section 2, we provide the technical background...