2014
DOI: 10.1097/01.tp.0000441089.39840.66
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Randomized Trial of Three Induction Antibodies in Kidney Transplantation

Abstract: Long-term results clearly indicate inferior clinical outcomes in group B.

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Cited by 35 publications
(31 citation statements)
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“…The prospective randomized trial that showed higher BPAR and lower graft survival in the AZ arm had minimized tacrolimus and mycophenolate mofetil only among those receiving AZ (14). In fact, through subset analysis, the authors found that the significantly poorer renal function observed in the AZ group was specifically a result of early underimmunosuppression of maintenance agents (14).…”
Section: Discussionmentioning
confidence: 90%
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“…The prospective randomized trial that showed higher BPAR and lower graft survival in the AZ arm had minimized tacrolimus and mycophenolate mofetil only among those receiving AZ (14). In fact, through subset analysis, the authors found that the significantly poorer renal function observed in the AZ group was specifically a result of early underimmunosuppression of maintenance agents (14).…”
Section: Discussionmentioning
confidence: 90%
“…A large retrospective analysis also found lower acute rejection rates and better early graft survival when full doses of tacrolimus and mycophenolate mofetil were administered in the context of steroid avoidance or early withdrawal (13); however, others have not (17). The prospective randomized trial that showed higher BPAR and lower graft survival in the AZ arm had minimized tacrolimus and mycophenolate mofetil only among those receiving AZ (14). In fact, through subset analysis, the authors found that the significantly poorer renal function observed in the AZ group was specifically a result of early underimmunosuppression of maintenance agents (14).…”
Section: Discussionmentioning
confidence: 99%
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“…Early attempts at steroid withdrawal were associated with high rejection rates and early graft failures (22)(23)(24). This trend changed with the incorporation of antibody induction into the protocols (25)(26)(27)(28). In the context of no steroid protocols, the current KDIGO guidelines recommend using a lymphocyte-depleting agent rather than an IL2-RA for kidney transplant recipients at higher risk for rejection (2B equals a moderate level of evidence).…”
Section: Steroid Avoidancementioning
confidence: 99%
“…Most are case reports describing alemtuzumab as salvage or induction therapy. 123,163,[166][167][168][169][170][171][172][173][174][175][176] In a small group of lung transplant recipients with rejection refractory to steroids and ATG, alemtuzumab appeared to be effective in reversing rejection and bronchiolitis obliterans syndrome. 177 Treatment of rejection appears similarly effective in kidney transplant recipients but may be associated with increased early infection-related deaths.…”
Section: Alemtuzumab (Campath)mentioning
confidence: 99%