1998
DOI: 10.1016/s0167-8140(98)00011-5
|View full text |Cite
|
Sign up to set email alerts
|

Randomized trial of single dose versus fractionated palliative radiotherapy of bone metastases

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

4
112
0
5

Year Published

1999
1999
2022
2022

Publication Types

Select...
9
1

Relationship

0
10

Authors

Journals

citations
Cited by 277 publications
(123 citation statements)
references
References 21 publications
4
112
0
5
Order By: Relevance
“…The indirect nature of the mechanism is suggested by the gradual onset and improvement in pain relief (one to four weeks) after initiating palliative radiation. 100,101,110,111 A shared mechanism is also suggested by the activity of corticosteroids, which not only relieve pain but are used to prevent delayed chemotherapy-induced nausea and emesis. 112 On the other hand, opioids to relieve pain, as well as metabolic abnormalities such as hypercalcemia, result in nausea and vomiting by activating the chemoreceptive trigger zone.…”
Section: Future Research On Crossover Interventionsmentioning
confidence: 99%
“…The indirect nature of the mechanism is suggested by the gradual onset and improvement in pain relief (one to four weeks) after initiating palliative radiation. 100,101,110,111 A shared mechanism is also suggested by the activity of corticosteroids, which not only relieve pain but are used to prevent delayed chemotherapy-induced nausea and emesis. 112 On the other hand, opioids to relieve pain, as well as metabolic abnormalities such as hypercalcemia, result in nausea and vomiting by activating the chemoreceptive trigger zone.…”
Section: Future Research On Crossover Interventionsmentioning
confidence: 99%
“…Although the efficacy and safety of radiotherapy using a single direct field for spinal bone metastases have been proven through numerous clinical trials for both single-and multi-fraction radiotherapy [7][8][9][10][11][12][13][14][15], a large number of respondents stated that they never use a single direct field for spinal bone metastases. Those who never use a single direct field may prefer to use parallel opposing fields or highly conformal radiotherapy.…”
Section: Discussionmentioning
confidence: 99%
“…Likewise, acute toxicity and quality of life are generally similar, although increased acute toxicity with multifraction treatments has been reported [Price et al 1986;Gaze et al 1997;Jeremic et al 1998;Nielsen et al 1998;Bone Pain Trial Working Party, 1999;Steenland et al 1999;Hartsell et al 2005]. These data indicate that excellent palliation of bone metastases can be achieved with single-fraction EBRT.…”
Section: Localized External Beam Radiotherapy For Bone Metastasesmentioning
confidence: 94%