Randomized Trial of Left Bundle Branch vs Biventricular Pacing for Cardiac Resynchronization Therapy

Proposed strategies to overcome venous occlusion in the implantation of a cardiac implantable electronic device: A case report and literature review

“…Currently, the majority of the studies are observational and nonrandomized ( 5 ). A recent small, randomized study including 40 patients demonstrated that LBBAP for CRT had greater LVEF improvement than BiV-CRT in heart failure with non-ischemic cardiomyopathy and LBBB ( 6 ). Large randomized controlled studies are required to verify the possible morbidity and mortality benefit of conduction system pacing for CRT.…”

Conduction system pacing for cardiac resynchronization therapy: State of the art, current controversies, and future perspectives

“…To date, only a small prospective randomized trial has been published on LBBAP compared to BVP in patients with HF (nonischemic cardiomyopathy-NICM) and LBBB with a 6-month followup (Wang et al, 2022). This study included 40 consecutive patients (20 males, mean age 63.7 years, LVEF 29.7% ± 5.6%).…”

Recruitment of the cardiac conduction system for optimal resynchronization therapy in failing heart

“…In the latest study including patients with AF after atrioventricular junction ablation, LBBP held higher successful implantation rates, better pacing parameters, and fewer lead-related complications compared with HBP, though both achieved similar improvement in clinical outcomes ( Cai et al, 2022 ). More recently, the first RCT (LBBP-RESYNC trail) to compare CRT efficacy between LBBP and BVP among heart failure patients with non-ischemic cardiomyopathy and LBBB found more improvement in LVEF by LBBP-CRT than BVP-CRT after 6-month follow-up ( Wang et al, 2022 ).…”