Randomized Trial Of Initial Trophic Vs. Full Enteral Feeding In Patients With Acute Lung Injury (EDEN)

The Effects of Critical Illness on Intestinal Glucose Sensing, Transporters, and Absorption*

“…Studies evaluating the effect of energy delivery on clinical outcomes, including mortality, have yielded conflicting results (26,27). However, providing fewer calories may lead to significant late morbidity with poorer functional outcomes following hospital discharge (28,29), leading to speculation that provision of 'full' feeding may protect against excessive catabolism and improve function in survivors (30).…”

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

“…Our systematic review identified seven randomized trials and 2665 patients studied [584,[586][587][588][589][590][591]. Patient populations included heterogeneous critically ill patients and those with acute lung injury and/or ARDS.…”

“…Patient populations included heterogeneous critically ill patients and those with acute lung injury and/or ARDS. Patients who were malnourished were excluded from four of the trials [588][589][590][591] and the average body mass index in the remaining three trials ranged from 28 to 30 [584,586,587]. Targets for trophic/hypocaloric feeding groups ranged from 10 to 20 kcal/h to up to 70% of target goal.…”

Enteral Nutrition After Advadvanced Combined Operative Interventions in Oncosurgery

“…В противоположность этому другая группа пациентов полу-чала энтеральное питание со скоростью от 10 до 30 мл/час (приблизительно 30% от целевого значения) в течение шести дней, а затем скорость знтерального питания уве-личивали до целевых значений (как и в первой группе). Исследование не обнаружило никаких различий в дли-тельности ИВЛ, 60-дневной смертности, частоте инфекци-онных осложнений [41,42]. Тем не менее в группе энте-рального питания с начальной низкой скоростью было меньше случаев рвоты, меньшие остаточные объемы желудка, более низкие средние уровни глюкозы в плазме.…”