Randomized trial between two active labor management protocols in the presence of an unfavorable cervix

Bolnick, Jay M.; Velazquez, Maria; González, Jose L.; Rappaport, Valerie J.; McIlwain-Dunivan, Gena; Rayburn, William F.

doi:10.1016/s0002-9378(03)00952-9

Cited by 19 publications

(29 citation statements)

References 9 publications

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“…Previous studies that used higher maximum oxytocin doses have not reported uterine hyperstimulation, further supporting the impression that concurrent oxytocin and vaginal prostaglandin for labor induction in women with an unfavorable cervix is safe [5,6,7,8]. The rate of uterine hyperstimulation for women in group B in our study was 8.4%, which is double the rate found in women in group A.…”

Section: Discussionsupporting

confidence: 85%

“…The interval from induction to delivery was 13.95 ± 4.53 h in group B. This time interval was shorter than reported in other studies of patients who underwent induction of labor with dinoprostone vaginal pessary with or without oxytocin [6,7,8,10]. A possible explanation for this difference is the dose of oxytocin which was used in our study.…”

Section: Discussioncontrasting

confidence: 48%

“…There are 5 studies on concurrent oxytocin infusion with prostaglandin administration for cervical ripening and labor induction [4,5,6,7,8]. Three of these studies have shown a shorter induction-to-delivery interval with concurrent oxytocin infusion with a prostaglandin agent at the initiation of labor, but the other 2 studies did not demonstrate a significantly shorter induction-to-delivery interval with concurrent oxytocin infusion [4,5,6,7,8]. However, in all of these studies the concurrent oxytocin infusion period and study populations were different.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sustained-Release Dinoprostone Vaginal Pessary with Concurrent High-Dose Oxytocin Infusion Compared to Sustained-Release Dinoprostone Vaginal Pessary Followed 6 h Later by High-Dose Oxytocin Infusion for Labor Induction in Women at Term with Unfavorable Cervix: A Randomized Controlled Trial

Güngördük

Yıldırım²,

Güngördük³

et al. 2010

Gynecol Obstet Invest

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Objective: To compare the efficacy and safety of sustained-release dinoprostone vaginal pessary and concurrent high-dose oxytocin infusion with sustained-release dinoprostone vaginal pessary followed 6 h later by high-dose oxytocin infusion for cervical ripening and labor induction. Methods: A total of 500 nulliparous or multiparous women with a singleton pregnancy, Bishop score ≤4 and admitted for labor induction. Women were randomly assigned to induction of labor using intravaginal dinoprostone with concurrent high-dose oxytocin (n = 250) or intravaginal dinoprostone pessary followed 6 h later by high-dose oxytocin (n = 250). The primary outcome was the number of vaginal deliveries achieved within 24 h of labor induction. Results: Baseline characteristics of both groups were comparable. Vaginal delivery within 24 h of labor induction was significantly increased with sustained-release dinoprostone followed 6 h later by high-dose oxytocin infusion (92.8 vs. 82.0%, RR 2.82, 95% CI 1.58–5.04). There were more cesarean section deliveries in the dinoprostone with concurrent high-dose oxytocin group (16.8 vs. 6.8%, RR 0.36, 95% CI 0.20–0.65). Maternal outcomes did not differ significantly. An Apgar score of <7 at 5 min was found more often in the dinoprostone with concurrent high-dose oxytocin group (3.6%) in comparison to dinoprostone pessary followed 6 h later by high-dose oxytocin (0.8%), although this was not statistically different (RR 0.21, 95% CI 0.04–1.01). Conclusion: Sustained-release dinoprostone followed 6 h later by high-dose oxytocin infusion appears to be safer and more effective than sustained-release dinoprostone with concurrent high-dose oxytocin infusion in achieving cervical ripening and successful vaginal delivery.

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Section: Discussionsupporting

confidence: 85%

Section: Discussioncontrasting

confidence: 48%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Sustained-Release Dinoprostone Vaginal Pessary with Concurrent High-Dose Oxytocin Infusion Compared to Sustained-Release Dinoprostone Vaginal Pessary Followed 6 h Later by High-Dose Oxytocin Infusion for Labor Induction in Women at Term with Unfavorable Cervix: A Randomized Controlled Trial

Güngördük

Yıldırım²,

Güngördük³

et al. 2010

Gynecol Obstet Invest

View full text Add to dashboard Cite

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“…Induction of labor has become a frequent clinical practice concerning approximately 20-30% of all pregnant women, half of them being induced in the presence of an unfavorable cervix [1,2]. Labor induction is known to cause worse pain than spontaneous labor, due to the pharmacological action of the drugs involved.…”

Section: Introductionmentioning

confidence: 99%

Induction of labor and pain: a randomized trial between two vaginal preparations of dinoprostone in nulliparous women with an unfavorable cervix

Zanconato

Bergamini

Mantovani

et al. 2011

The Journal of Maternal-Fetal & Neonatal Medicine

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“…Sifleler et al found no statistically significant differences in hyperstimulation rates among misoprostol, oxytocin, and dinoprostone (21). In other studies, hyperstimulation rates for dinoprostone were reportedly higher than hyperstimulation rates for misoprostol (22,23,24). In the present study, one advantage is the relatively large study population, which included nulliparous and multiparous women.…”

Section: Discussionmentioning

confidence: 50%

Labor induction: comparison between oxytocin and dinoprostone

Yurtsever¹,

Cengiz²,

Yurtsever³

et al. 2013

Gaziantep Med J

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Labor induction is one of the most frequent procedures in pregnant women. The optimal regimen for preinduction cervical ripening and labor induction is not established. The aim of the present study was to compare the efficacy and safety of vaginal dinoprostone and intravenous oxytocin administration for labor induction. The medical records of the patients who had induction of labor at Okmeydanı Teaching and Research Hospital, Department of Obstetrics and Gynecology from January 2010 to June 2011 were evaluated retrospectively. The first group (143 patients) received a single dose of sustained-released dinoprostone 10 mg, which was inserted high into the vaginal fornix. The second group (151 patients) received intravenous oxytocin (synpitan). Maternal and fetal outcomes were compared. There were no significant differences between the two groups for parity, birth weight, fetal gender and mode of delivery. 195 (66.3%) of patiens had vaginal delivery and 99 (33.7%) had cesarean delivery. The median time from start of induction of labor to vaginal birth was longer when a prostaglandin E2 was used for labor induction than it was when oxytocin was used (20.1 hours vs 16.1 hours) (p<0.01). No maternal death or uterine rupture occurred. Neonatal weight, admission to neonatal unit, 1 and 5-minute Apgar score <7, did not differ significantly between two groups (p>0.05). Oxytocin is safe, effective and cost-effective treatment. The current study shows that sustained-released Dinoprostone which is an FDA (U.S. Food and Drug Administration) approved drug; is an alternative method for the induction of labor although it is not cost effective. Keywords: Cervical ripening; dinoprostone; labor induction; oxytocin. Özet

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Randomized trial between two active labor management protocols in the presence of an unfavorable cervix

Cited by 19 publications

References 9 publications

Sustained-Release Dinoprostone Vaginal Pessary with Concurrent High-Dose Oxytocin Infusion Compared to Sustained-Release Dinoprostone Vaginal Pessary Followed 6 h Later by High-Dose Oxytocin Infusion for Labor Induction in Women at Term with Unfavorable Cervix: A Randomized Controlled Trial

Sustained-Release Dinoprostone Vaginal Pessary with Concurrent High-Dose Oxytocin Infusion Compared to Sustained-Release Dinoprostone Vaginal Pessary Followed 6 h Later by High-Dose Oxytocin Infusion for Labor Induction in Women at Term with Unfavorable Cervix: A Randomized Controlled Trial

Induction of labor and pain: a randomized trial between two vaginal preparations of dinoprostone in nulliparous women with an unfavorable cervix

Labor induction: comparison between oxytocin and dinoprostone

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