Induction of labor and pain: a randomized trial between two vaginal preparations of dinoprostone in nulliparous women with an unfavorable cervix

Abstract

The two induction procedures should be considered equivalent as far as ripening the cervix and initiating labor. In view of this finding, the low Bishop score should be considered an indication to prefer the controlled-release device, since it reduces pain thereby improving the physical and emotional wellbeing of the parturient.

Use of labor induction with dinoprostone vaginal suppositories in pregnant women with gestational hypertension

“…Thus, we considered that labor induction with Propess had a satisfactory vaginal delivery rate, indicating that use of Propess is a safe and effective labor induction way for pregnant women with gestational hypertension. It was reported that the average vaginal delivery rate within 24 h of Dinoprostone vaginal insert was 59.4% (range: 38.2–81.1%) . In addition, our previous study of the use of Propess in healthy pregnancies showed a vaginal delivery rate of 76.09%, which was also consistent with our present study.…”

Vaginal Dinoprostone Versus Intravenous Oxytocin for Labor Induction in Patients Not Responsive to a First Dose of Dinoprostone: A Randomized Prospective Study

“…In this context, a 2014 Cochrane review states that prostaglandins are effective for labor induction and increase the chance of vaginal delivery in 24 hours. 4 Dinoprostone vaginal insert is associated with an average cesarean section rate of 25% (range 10.5%-38.6%) [12][13][14][15][16][17][18][19][20][21][22][23] and a rate of vaginal delivery within 24 hours of 59.4% (range 38.2%-81.1%). [13][14][15][16][17][18][19][20]22,23 Recently, Facchinetti et al 24 proposed that in nulliparous women with an unprepared cervix and intact membranes, the vaginal insert shows a protective effect toward cesarean section.…”

Prediction of the efficacy of dinoprostone slow release vaginal insert (Propess) for cervical ripening: A prospective cohort study

“…One widely used product for vaginal PGE 2 administration is a preparation of controlled release dinoprostone (Propess, Ferring, Saint‐Prex, Switzerland), which is available as a 10 mg, slow release vaginal insert that releases a dose of dinoprostone at a rate of 0.3 mg/h for 24 h. The advantages of this vaginal delivery system are that it is easy to apply and can be removed quickly by pulling the attached string . Vaginal dinoprostone pessaries were shown to be as effective as gel for cervical ripening and initiation of labor, but were superior in regard to pain experienced by patients …”

“…21,22 Vaginal dinoprostone pessaries were shown to be as effective as gel for cervical ripening and initiation of labor, but were superior in regard to pain experienced by patients. 23 This study evaluated factors related to the success of dinoprostone slow release insert for cervical ripening. The primary outcome was successful vaginal delivery and the secondary outcome was successful ripening.…”