Prediction of the efficacy of dinoprostone slow release vaginal insert (Propess) for cervical ripening: A prospective cohort study

Daykan, Yair; Biron‐Shental, Tal; Navve, Daniella; Miller, Netanella; Bustan, Mor; Sukenik-Halevy, Rivka

doi:10.1111/jog.13715

Cited by 24 publications

(27 citation statements)

References 34 publications

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“…The induction-to-birth interval was significantly shorter and the proportion of vaginal deliveries within 24 h was higher in the Propess group than in the Prostin E2 group. The success rates were higher (90% and 96.7% in the Prostin and Propess groups, respectively) than those in many other previous studies, with a success rate ranging from 71% to 90.4% [ 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 ]. We assumed that the efficacy of Propess would be better than that of Prostin E2 tablets in IOL.…”

Section: Discussioncontrasting

confidence: 61%

Comparison of the Dinoprostone Vaginal Insert and Dinoprostone Tablet for the Induction of Labor in Primipara: A Retrospective Cohort Study

Ting

Ding

Wei

2022

JCM

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This retrospective study aimed to compare the safety and efficacy of Prostin E2 and Propess for the induction of labor (IOL) in nulliparous women between January 2018 and October 2021. The inclusion criteria were nulliparous, singleton, >37 weeks’ gestation, cephalic presentation with an unfavorable cervix (Bishop score ≤ 6), no signs of labor, and use of one form of dinoprostone (Prostin E2 or Propess) for IOL. The cesarean section (C/S) rate and induction-to-birth interval were the main outcome measures. In total, 120 women were recruited. Sixty (50%) patients received Propess and 60 (50%) received repeated doses of Prostin E2. The Prostin E2 and Propess groups had similar patient characteristics, but the Bishop score was significantly higher in the Propess group than in the Prostin E2 group; therefore, multivariate analysis was conducted, and the Bishop score was not associated with the induction-to-birth interval. The C/S rate was not significantly different between the two groups, but the Propess group achieved a shorter induction-to-birth interval, a higher rate of vaginal delivery in 24 h, and a lower number of vaginal examinations than the Prostin E2 group. Propess was effective and safe in IOL and could be an option for cervical ripening in nulliparous pregnancy.

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Section: Discussioncontrasting

confidence: 61%

Comparison of the Dinoprostone Vaginal Insert and Dinoprostone Tablet for the Induction of Labor in Primipara: A Retrospective Cohort Study

Ting

Ding

Wei

2022

JCM

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“…Prostaglandin E 2 exerts an oxytocic effect on the myometrium, which increases uterine tone and tends to decrease uteroplacental perfusion [ 9 ]. Uterine hyperstimulation is a common side effect of prostaglandin preparations used for labor induction [ 8 ]. Additionally, Chen et al reported that the use of prostaglandin to induce labor was associated with a higher rate of uterine hyperstimulation accompanied with FHR changes than the mechanical cervical ripening intervention [ 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…The PROPESS would become common in Japan because of less pain associated with insertion and a lower risk of intrauterine infection than the mechanical cervical ripening intervention [ 7 ]. However, the PROPESS promotes cervical change with causing uterine contraction compared to the mechanical cervical ripening intervention, and uterine hyperstimulation could occur [ 8 ]. Moreover, uterine hyperstimulation occasionally results in fetal heart rate (FHR) abnormality.…”

Section: Introductionmentioning

confidence: 99%

The Successful Use of Nitroglycerin for Uterine Hyperstimulation with Fetal Heart Rate Abnormality Caused by a Controlled-Release Dinoprostone Vaginal Delivery System (PROPESS): A Case Report

et al. 2021

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The PROPESS, a controlled-release dinoprostone vaginal delivery system, is a pharmacological cervical ripening intervention and promotes cervical change causing uterine contraction. During insertion of the PROPESS, uterine hyperstimulation could occur and result in fetal heart rate (FHR) abnormality. We report a case of uterine hyperstimulation accompanied with FHR abnormality caused by the PROPESS in a pregnant woman. Postural change, oxygenation, fluid infusion, and the immediate PROPESS removal were ineffective to address the adverse event, so we administered nitroglycerin for acute uterine relaxation. The nitroglycerin resulted in uterine relaxation, and the FHR abnormality was resolved immediately, thereby preventing an emergency cesarean section. Therefore, nitroglycerin could be considered an effective option for uterine hyperstimulation accompanied with FHR abnormality caused by the PROPESS.

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“…5,6 Moreover, PROPESS has the advantage of less pain associated with insertion and a lower risk of intrauterine infection over mechanical cervical ripening methods 7 ; while, it promotes cervical change, which causes uterine contraction, and could cause uterine hyperstimulation. 8 Uterine hyperstimulation could cause non-reassuring fetal heart rate (FHR) patterns. 5 A previous Japanese study compared PROPESS and a placebo 4 ; however, there has been no Japanese study comparing PROPESS and mechanical cervical ripening methods.…”

Section: Introductionmentioning

confidence: 99%

Comparison of perinatal outcomes between controlled‐release dinoprostone vaginal delivery system (PROPESS) and metreurynter for cervical ripening in labor induction: A retrospective single‐center study in Japan

Yamaguchi

Takakura

Enomoto

et al. 2021

J of Obstet and Gynaecol

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Aim: This study aimed to compare the efficacy and safety of a controlled-release dinoprostone vaginal delivery system (PROPESS) and a metreurynter for labor induction. Methods: This retrospective case-controlled study included 117 pregnant women (51 and 66 in the PROPESS and metreurynter groups, respectively) who required labor induction after >37 weeks' gestation at Mie University Hospital between January 2018 and September 2020. The primary outcome was the success rate of vaginal delivery. The secondary outcomes were changes in the Bishop score from the first insertion of PROPESS or the metreurynter to removal, uterine hyperstimulation and non-reassuring fetal status during the first insertion, proportion of pregnant women who needed pre-delivery oxytocin after removal, time to vaginal delivery after the first insertion, proportion of pregnant women who delivered vaginally within 12 or 24 h after the first insertion, and neonatal outcomes. Results: The proportion of pregnant women, especially primiparas, who delivered vaginally was significantly higher in the PROPESS group (26/34 [76.5%]) than in the metreurynter group (25/52 [48.1%]; p = 0.01). Moreover, among multiparas in the PROPESS group who delivered vaginally, nine (56.3%) out of 16 women delivered vaginally within 3 h of labor onset. Conclusions: PROPESS for cervical ripening may reduce the risk of undergoing cesarean section in pregnant women requiring labor induction, especially primiparas. It is important to consider the possibility of precipitate labor when using the PROPESS in multiparas.

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Prediction of the efficacy of dinoprostone slow release vaginal insert (Propess) for cervical ripening: A prospective cohort study

Abstract: The success of cervical ripening with dinoprostone slow release vaginal insert can be predicted by factors that can be recognized at admission.

Cited by 24 publications

References 34 publications

Comparison of the Dinoprostone Vaginal Insert and Dinoprostone Tablet for the Induction of Labor in Primipara: A Retrospective Cohort Study

Comparison of the Dinoprostone Vaginal Insert and Dinoprostone Tablet for the Induction of Labor in Primipara: A Retrospective Cohort Study

The Successful Use of Nitroglycerin for Uterine Hyperstimulation with Fetal Heart Rate Abnormality Caused by a Controlled-Release Dinoprostone Vaginal Delivery System (PROPESS): A Case Report

Comparison of perinatal outcomes between controlled‐release dinoprostone vaginal delivery system (PROPESS) and metreurynter for cervical ripening in labor induction: A retrospective single‐center study in Japan

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