Randomized, double-blind placebo-controlled trial with Bryophyllum pinnatum versus placebo for the treatment of overactive bladder in postmenopausal women

Betschart, Cornelia; Mandach, Ursula von; Seifert, Burkhardt; Scheiner, David; Perucchini, Daniele; Fink, Daniel; Geissbühler, Verena

doi:10.1016/j.phymed.2012.10.007

Cited by 29 publications

(35 citation statements)

References 32 publications

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“…Two phenolic acids, several flavonol and O-methylated flavone glycosides, a bufadienolide, and lysophosphatidylcholine derivatives were identified for the first time in this plant which is currently the object of clinical investigations in different therapeutic indications [10,11]. Two flavonol glycosides were new natural products.…”

Section: Resultsmentioning

confidence: 96%

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Two New Flavonol Glycosides and a Metabolite Profile of Bryophyllum pinnatum, a Phytotherapeutic Used in Obstetrics and Gynaecology

et al. 2013

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Bryophyllum pinnatum is a succulent perennial plant native to Madagascar which is used in anthroposophical medicine to treat psychiatric disorders and as a tocolytic agent to prevent premature labour. We performed a metabolite profiling study in order to obtain a comprehensive picture of the constituents in B. pinnatum leaves and to identify chromatographic markers for quality control and safety assessment of medicinal preparations. Preliminary HPLC-PDA-ESIMS analyses revealed that flavonoid glycosides were the main UV-absorbing constituents in the MeOH extract of B. pinnatum. Two phenolic glucosides, syringic acid -D-glucopyranosyl ester (1) and 4'-O--D-glucopyranosyl-cis-p-coumaric acid (2), as well as nine flavonoids (3-11) including kaempferol, quercetin, myricetin, acacetin, and diosmetin glycosides were unambiguously identified by 1H and 2D NMR analysis after isolation from a MeOH extract. The flavonol glycosides quercetin 3-O--L-arabinopyranosyl-(1 → 2)--L-rhamnopyranoside 7-O--D-glucopyranoside (3) and myricetin 3-O--L-arabinopyranosyl-(1 → 2)--L-rhamnopyranoside (4) were new natural products. With the aid of HPLC-PDA-APCIMS and authentic references isolated from the related species B. daigremontianum, the presence of four bufadienolides, bersaldegenin-1-acetate (12), bryophyllin A (13), bersaldegenin-3-acetate (14), and bersaldegenin-1,3,5-orthoacetate (15) AbstractBryophyllum pinnatum is a succulent perennial plant native to Madagascar which is used in anthroposophical medicine to treat psychiatric disorders, and as a tocolytic agent to prevent premature labour. We performed a metabolite profiling study in order to obtain a comprehensive picture of the constituents in B. pinnatum leaves, and to identify chromatographic markers for quality control and safety

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Section: Resultsmentioning

confidence: 96%

“…To explore the potential of B. pinnatum as a treatment for patients suffering from overactive bladder syndrome, a pilot study in humans was performed. A positive trend for a B. pinnatum preparation compared to placebo could be shown [11].…”

Section: Introductionmentioning

confidence: 95%

Two New Flavonol Glycosides and a Metabolite Profile of Bryophyllum pinnatum, a Phytotherapeutic Used in Obstetrics and Gynaecology

et al. 2013

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“…The primary endpoint, the micturition frequency/24 h, was reduced from 9.5 before to 7.8 after the treatment (p = 0.064). The quality of life (QoL) was comparable in the B. pinnatum and placebo group [74]. The effect of B. pinnatum leaf press juice on porcine detrusor muscle contractility was investigated in an organ bath chamber, in comparison with oxybutynin as a reference drug.…”

Section: Overactive Bladder (Oab) Syndromementioning

confidence: 99%

“…Another study revealed no significant difference in observed side effects. One woman treated with B. pinnatum 50 % chewable tablets suffered from diarrhea and dysentery, possibly due to lactose intolerance, and a second woman developed exanthema of the face and upper thorax [74]. In a longitudinal, prospective, randomized, controlled animal study, the effect of the mother tincture (MT), 30 % of B. pinnatum, in pregnant Wistar rats was investigated.…”

Section: Wound Healing Activitymentioning

confidence: 99%

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

et al. 2016

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ReviewsThis document was downloaded for personal use only. Unauthorized distribution is strictly prohibited.Bryophyllum (see below) [4]. While these reviews describe various compounds and bioactivities, none of them addresses the pharmacological and clinical data that support the therapeutic use of Bryophyllum preparations in European countries. The present review focuses on B. pinnatum, but the few data available on Bryophyllum daigremontianum, Bryophyllum delagoense, and the hybrid Bryophyllum daigremontianum x tubiflorum have also been included. The German homeopathic pharmacopeia (HAB) 2014 [5] lists the two species B. pinnatum and B. daigremontianum as officinal in its monography "Bryophyllum Rh", and both have been used in AM. B. delagoense was introduced in the 1980s as an anthroposophic medicinal product in Germany, primarily for sedative purposes (Personal communication, Dr. med. Siegward-M. Elsas, see Acknowledgments). Botany

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“…Eine randomisierte, doppelblinde, Placebo-kontrollierte Studie zeigte eine Reduktion der Miktionsfrequenz nach Verabreichung von B. pinnatum im Vergleich zu Placebo bei Frauen in den Wechseljahren [17]. Der positive Effekt auf die Blase konnte durch In-vitro-Experimente an der Schweineblase bestätigt werden [18,19].…”

Section: Introductionunclassified

Die Anwendung von <b><i>Bryophyllum pinnatum</i></b>-Präparaten in der Geburtshilfe und Gynäkologie - eine multizentrische prospektive Beobachtungsstudie

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Simões-Wüst²,

Winkler³

et al. 2015

Complement Med Res

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Hintergrund:Bryophyllum pinnatum wurde durch die anthroposophische Medizin in Europa eingeführt und wird heutzutage auch in der konventionellen Medizin breit angewendet. Ziel dieser Studie war es, die Verordnungen im Bereich Gynäkologie und Geburtshilfe in der Schweiz sowie das Wirkungspotenzial von B. pinnatum und mögliche unerwünschte Ereignisse zu erfassen. Patienten und Methoden: Arztpraxen und Kliniken für Geburtshilfe und Gynäkologie wurden gebeten, die Verordnungen von B. pinnatum bei ihren Patientinnen im Zeitraum von 31 Monaten mittels eines Online-Fragebogens zu dokumentieren. Ergebnisse: Am UniversitätsSpital Zürich, am Kantonsspital Winterthur sowie in 2 Arztpraxen wurden bei insgesamt 174 Frauen 208 Verordnungen mit B. pinnatum erfasst (mehrere Verordnungen pro Patientin möglich). Der überwiegende Anteil der Patientinnen war schwanger (87%). B. pinnatum wurde bei 83% aller Frauen bzw. bei 95% der Schwangeren als Tokolytikum bei Frühgeburtsbestrebungen verordnet und zeigte eine gute bis sehr gute Wirkung. Wegen innerer Unruhe erhielten 14% der Patientinnen B. pinnatum zur Sedation am Tag und 5% zur Sedation bei Schlafproblemen. Für diese beiden Indikationen konnte die Unruhe gemindert werden. 13% der Frauen litten an einer hyperaktiven Blase, deren Therapie mit B. pinnatum in zwei Drittel der Fälle als sehr wirksam eingestuft wurde. Für die Behandlung wurde in 92% der Fälle Kautabletten Bryophyllum 50% verschrieben. Schlussfolgerungen: Im Bereich der konventionellen Gynäkologie und Geburtshilfe wird B. pinnatum überwiegend bei schwangeren Patientinnen verordnet, dabei vor allem bei vorzeitigen Wehen, innerer Unruhe und hyperaktiver Blase. B. pinnatum zeigte eine gute Wirkung in der Behandlung dieser mit Hyperaktivität verbundenen Beschwerden.

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Randomized, double-blind placebo-controlled trial with Bryophyllum pinnatum versus placebo for the treatment of overactive bladder in postmenopausal women

Cited by 29 publications

References 32 publications

Two New Flavonol Glycosides and a Metabolite Profile of Bryophyllum pinnatum, a Phytotherapeutic Used in Obstetrics and Gynaecology

Two New Flavonol Glycosides and a Metabolite Profile of Bryophyllum pinnatum, a Phytotherapeutic Used in Obstetrics and Gynaecology

Bryophyllum pinnatum and Related Species Used in Anthroposophic Medicine: Constituents, Pharmacological Activities, and Clinical Efficacy

Die Anwendung von <b><i>Bryophyllum pinnatum</i></b>-Präparaten in der Geburtshilfe und Gynäkologie - eine multizentrische prospektive Beobachtungsstudie

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