Randomized controlled trial to evaluate the efficacy of oral lycopene in combination with vitamin E and selenium in the treatment of oral leukoplakia

Patel, Jyotsna Sandeep; Umarji, Hemant R; Dhokar, Amol; Sapkal, Rashmi; Patel, Sandeep G.; Panda, A.K.

doi:10.4103/0972-1363.155630

Cited by 6 publications

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“…Patel et al . [ 8 ] found a significant improvement in group A (combination of vitamin E selenium and lycopene) group compared to placebo similar to our findings. Singh et al .…”

Section: Discussionsupporting

confidence: 90%

Assessment of utility of lycopene, selenium, and Vitamin E in management of oral leukoplakia

Manas¹,

Venkateswararao

Vaid

et al. 2022

J Pharm Bioall Sci

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Objectives: To assess the utility of lycopene, selenium, and vitamin E in the management of leukoplakia. Materials and Methods: In this cross-sectional observational prospective study, 52 patients of oral leukoplakia were divided into 2 groups. Group I patients were prescribed 6 mg of lycopene, 400 I.U. of vitamin E, and 200 μg of selenium twice a day. Group II patients were prescribed a placebo capsule. The clinical improvement was recorded in both groups. Results: The mean pretreatment size of lesion in group I was 9.24 cm 2 and in group II was 8.52 cm 2 . Post treatment size was 1.52 cm 2 in group I and 6.28 cm 2 in group II. There was a significant reduction in the size of lesion in group I compared to group II ( P < 0.05). Conclusion: The treatment with a combination of lycopene, selenium, and vitamin E is useful and effective in managing the cases of oral leukoplakia.

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“…Patel et al . [ 8 ] found a significant improvement in group A (combination of vitamin E selenium and lycopene) group compared to placebo similar to our findings. Singh et al .…”

Section: Discussionsupporting

confidence: 90%

Assessment of utility of lycopene, selenium, and Vitamin E in management of oral leukoplakia

Manas¹,

Venkateswararao

Vaid

et al. 2022

J Pharm Bioall Sci

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“…found that lycopene in combination with Vitamin E and selenium was effective in reducing the clinical size of the lesion in patients with leukoplakia. [ 23 ] Studies carried out by investigators like Nagasawa et al .,[ 24 ] Sharoni et al .,[ 25 ] Narisawa et al .,[ 26 ] and Bhuvaneshwari et al . [ 27 ] have suggested lycopene to be an effective agent in inhibiting carcinogenesis.…”

Section: Discussionmentioning

confidence: 99%

Comparison of effectiveness of Calendula officinalis extract gel with lycopene gel for treatment of tobacco-induced homogeneous leukoplakia: A randomized clinical trial

Singh

Bagewadi

2017

Int J Pharma Investig

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Aim:The aim of the study is to assess the efficacy of Calendula officinalis gel as cost-effective treatment modality in comparison to lycopene gel in the treatment of leukoplakia.Materials and Methods:The study comprised of sixty patients of clinically diagnosed and histopathologically confirmed cases of homogeneous leukoplakia which were divided into Group I and Group II with thirty patients each. Group I patients were dispensed C. officinalis extract gel whereas Group II patients were given lycopene gel. The therapy was instituted for 1 month to assess the change in the size of the lesion at the baseline and posttreatment.Results:The results revealed a statistically significant difference in both Group I and Group II when the pre- and post-treatment results were compared in the same group. The mean difference in the reduction in size before and after treatment for Group I was 2.0% ±1.0 cm while for the Group II, it was 1.57% ±0.87 cm. The intergroup comparison for the evaluation of reduction in the size of the lesion did not reveal statistically significant results.Conclusion:C. officinalis extract gel can be effectively used as an alternative to conventional treatment modality.

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“…Patel JS i sar. 59 su otkrili da je likopen zajedno sa vitaminom E i selenom pokazao kliničko i histološko poboljšanje u poređenju sa placebom.…”

Section: Medicinski Tretmanunclassified

Oral leukoplakia: A review of clinical features and trends in management

Pandita¹,

Ajila²,

Babu³

et al. 2022

Acta stomatologica Naissi

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Introduction: Oral potentially malignant disorders (OPMD) conisit of the group of diseases of great importance for dentists. Oral leukoplakia (OL) has long been the subject of debate by numerous researchers. A common etiologic factor is tobacco, which is associated with oral cancer. The aim of the study is to indicate the severity of the lesion, the most common clinical characreistics and localization. The prevalence of leukoplakia in the world is 2.6% with a rate of malignant conversion ranging from 0.1% to 17.5%. Literature data about the prevalence and annual rate of malignant transformation, approximately 2%, indicate that these changes should be taken seriously and regularymonitored Conclusion: Occurate diagnosis provides the key to preventing to malignant transformation. Various medical and surgical treatment modalities for this lesion have been described. This article highlights various trends in the diagnosis and treatment of oral leukoplakia.

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Randomized controlled trial to evaluate the efficacy of oral lycopene in combination with vitamin E and selenium in the treatment of oral leukoplakia

Cited by 6 publications

References 0 publications

Assessment of utility of lycopene, selenium, and Vitamin E in management of oral leukoplakia

Assessment of utility of lycopene, selenium, and Vitamin E in management of oral leukoplakia

Comparison of effectiveness of Calendula officinalis extract gel with lycopene gel for treatment of tobacco-induced homogeneous leukoplakia: A randomized clinical trial

Oral leukoplakia: A review of clinical features and trends in management

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