Comparison of effectiveness of Calendula officinalis extract gel with lycopene gel for treatment of tobacco-induced homogeneous leukoplakia: A randomized clinical trial

Abstract

Aim:The aim of the study is to assess the efficacy of Calendula officinalis gel as cost-effective treatment modality in comparison to lycopene gel in the treatment of leukoplakia.Materials and Methods:The study comprised of sixty patients of clinically diagnosed and histopathologically confirmed cases of homogeneous leukoplakia which were divided into Group I and Group II with thirty patients each. Group I patients were dispensed C. officinalis extract gel whereas Group II patients were given lycopene gel. The therapy was instituted for 1 month to assess the change in the size of the lesion at the baseline and posttreatment.Results:The results revealed a statistically significant difference in both Group I and Group II when the pre- and post-treatment results were compared in the same group. The mean difference in the reduction in size before and after treatment for Group I was 2.0% ±1.0 cm while for the Group II, it was 1.57% ±0.87 cm. The intergroup comparison for the evaluation of reduction in the size of the lesion did not reveal statistically significant results.Conclusion:C. officinalis extract gel can be effectively used as an alternative to conventional treatment modality.

Effect of lycopene supplementation on cardiovascular parameters and markers of inflammation and oxidation in patients with coronary vascular disease

“…There are a number of recently published clinical trials and metaanalysis data revealing beneficial health effects of lycopene (Cicero & Colletti, 2015;Mahmoodnia, Mohammadi, & Masumi, 2017;Singh & Bagewadi, 2017;van Die et al, 2016). However, only few of them (Graff et al, 2017;Zhu, Gertz, Cai, & Burri, 2016) adequately address the issue of lycopene bioavailability in volunteers.…”

Oral Submucous Fibrosis

“…Lycopene is main carotenoid mostly found in tomatoes, having potent anticancer activity in variety of cancer. 11 Antioxidant activity of lycopene have role in treatment of many chronic diseases and in early symptoms. In many oral diseases like OSF, leukoplakia and malignant lesions lycopene play an important role for the management plan.…”

Traditional plants from Asteraceae family as potential candidates for functional food industry

“…165 For leukoplakia, C. officinalis showed an equivalent efficacy as that of lycopene. 166 However, as it happens in clinical trials performed with other TP, the experimental design and outcome measures are very variable between different studies; therefore, well-designed and validated protocols are required to determine the efficacy of calendula. 163 The EMA considers the use of C. nobile as a therapeutic for mild, spasmodic gastrointestinal complaints (bloating and flatulence) or for treating minor mouth or throat inflammations.…”