Randomized controlled trial of the effects of consumption of ‘Yabukita’ or ‘Benifuuki’ encapsulated tea-powder on low-density lipoprotein cholesterol level and body weight

Igarashi, Yuko; Obara, Taku; Ishikuro, Mami; Matsubara, Hiroko; Shigihara, Michiko; Metoki, Hirohito; Kikuya, Masahiro; Sameshima, Yoichi; Tachibana, Hirofumi; Maeda‐Yamamoto, Mari; Kuriyama, Shinichi

doi:10.1080/16546628.2017.1334484

Cited by 9 publications

(7 citation statements)

References 20 publications

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“…In all, the antagonistic effect of zinc selenium tea on a HSHF diet was pronounced. The results were in accordance with previous lipometabolism studies 27 – 29 .…”

Section: Discussionsupporting

confidence: 93%

“…In addition, in a randomized controlled trial, Yuko et al . (2017) demonstrated that Japanese green tea may lower low-density lipoprotein cholesterol, and the magnitude of the lipid-lowering effect of the tea was significantly larger than that of placebo 29 . In this study, we designed a HSHF diet animal group via mimicking human diet habits.…”

Section: Discussionmentioning

confidence: 99%

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Protective effects of Chinese Fenggang zinc selenium tea on metabolic syndrome in high-sucrose-high-fat diet-induced obese rats

Yang

et al. 2018

Sci Rep

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The protective effect of zinc selenium tea against metabolic syndrome (MetS) was tested by using a high-sucrose-high-fat diet (HSHFD)-induced MetS model. Fifty Sprague–Dawley rats were randomly divided into five groups: normal diet (C-group), HSHFD (CH-group), HSHFD + green tea (0.24 g/kg/day) (TH-group), HSHFD + low-dose zinc selenium organic tea (0.24 g/kg/day) (ZTHL-group), and HSHFD + high-dose zinc selenium organic tea (1.20 g/kg/day) (ZTHH-group). After 8 weeks, compared to both the C-group and CH-group, the hepatosomatic index (HI) was significantly reduced in the ZTHL-group (p < 0.05). Fasting blood glucose (FBG) levels were highest in the TH-group, followed by the CH-group, then the ZTHL-group, then the ZTHH-group, and finally the C-group. Compared with the CH-group, the serum total cholesterol (TC) and low density lipid-cholesterol (LDL-C) concentrations were significantly lower in the ZTHH-group (p < 0.05). Significant decreases in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bile acids (TBA), alkaline phosphatase (ALP), and direct bilirubin (DBIL) levels were observed in ZTHL-group versus the CH-group (p < 0.05). Serum alpha-L-fucosidase (AFU) levels in the ZTHH-group were lower than in the CH-group (P < 0.01). Histopathological examination of the liver and fat biopsies illustrates that the liver cells showed a decrease in the extent of necrosis and dropsy in the ZTHL-group and ZTHH-group versus the CH-group. Zinc selenium tea showed a protection effect against hepatic damage.

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“…In all, the antagonistic effect of zinc selenium tea on a HSHF diet was pronounced. The results were in accordance with previous lipometabolism studies 27 – 29 .…”

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Protective effects of Chinese Fenggang zinc selenium tea on metabolic syndrome in high-sucrose-high-fat diet-induced obese rats

Yang

et al. 2018

Sci Rep

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“…Benifuuki green tea, containing O-methylated catechin, was shown to remarkably reduce serum concentrations of LDL-C and lectin-like oxidized low-density lipoprotein receptor-1 ligands containing apolipoprotein B (LAB) in a randomized controlled trial (RCT) conducted on 155 volunteers [85]. Another RCT including 151 volunteer subjects also showed that Benifuuki and Yabukita green teas could decrease the LDL-C level [86]. In addition, consumption of green tea catechin extract for one year could lower serum TC ( p = 0.0004), LDL-C ( p < 0.0001), and non-HDL cholesterol ( p = 0.0032) in healthy postmenopausal women [26].…”

Section: Clinical Trailsmentioning

confidence: 99%

Effects and Mechanisms of Tea and Its Bioactive Compounds for the Prevention and Treatment of Cardiovascular Diseases: An Updated Review

et al. 2019

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Cardiovascular diseases (CVDs) are critical global public health issues with high morbidity and mortality. Epidemiological studies have revealed that regular tea drinking is inversely associated with the risk of CVDs. Additionally, substantial in vitro and in vivo experimental studies have shown that tea and its bioactive compounds are effective in protecting against CVDs. The relevant mechanisms include reducing blood lipid, alleviating ischemia/reperfusion injury, inhibiting oxidative stress, enhancing endothelial function, attenuating inflammation, and protecting cardiomyocyte function. Moreover, some clinical trials also proved the protective role of tea against CVDs. In order to provide a better understanding of the relationship between tea and CVDs, this review summarizes the effects of tea and its bioactive compounds against CVDs and discusses potential mechanisms of action based on evidence from epidemiological, experimental, and clinical studies.

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“…However, findings from randomized controlled trials (RCTs) on green tea supplementation and glycemic control or insulin sensitivity in individuals with preclinical diabetes or T2DM are debatable. Some studies observed that green tea significantly improve glycemic control [12], whereas others found no significant association between green tea intake and glycemic control [13,14].…”

Section: Introductionmentioning

confidence: 99%

Effects of green tea consumption on glycemic control: a systematic review and meta-analysis of randomized controlled trials

Bai

Yang

et al. 2020

Nutr Metab (Lond)

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Background: The results of human clinical trials investigating the effects of green tea on glycemic control are inconsistent. Methods: We conducted a systematic review and meta-analysis of RCTs that examined the effects of green tea supplementation on glycemic control. A literature search in PubMed, Embase, and Cochrane Library databases for RCTs that investigated the effect of green tea consumption on glycemic control was performed up to February 2020. A random-effects model was used to estimate weighted mean difference (WMD) with 95% confidence intervals (CIs). Results: Twenty-seven trials involving 2194 subjects were included in the meta-analysis. The pooled results showed that green tea significantly lowered fasting blood glucose by − 1.44 mg/dL (95%CI:-2.26, − 0.62 mg/dL; P < 0.001) with no obvious heterogeneity (I 2 = 7.7%). However, green tea consumption did not significantly affect fasting insulin and HbA1c values. The mean differences were − 0.46μIU/mL (95% CI: − 1.10, 0.17μIU/mL; P = 0.21) for fasting insulin and − 0.06%; (95% CI: − 0.12, 0.01%; P = 0.07) for HbA 1c concentrations. Heterogeneity was significant in fasting insulin (I 2 = 46.8%) and mild in HbA 1c (I 2 = 1.7%). Conclusions: In short-term trials, green tea supplementation significantly reduced fasting glucose, but had no significant effect on fasting insulin and HbA 1c. Long-term trials assessing the effects of green tea supplementation on glycemic control are needed.

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Randomized controlled trial of the effects of consumption of ‘Yabukita’ or ‘Benifuuki’ encapsulated tea-powder on low-density lipoprotein cholesterol level and body weight

Cited by 9 publications

References 20 publications

Protective effects of Chinese Fenggang zinc selenium tea on metabolic syndrome in high-sucrose-high-fat diet-induced obese rats

Protective effects of Chinese Fenggang zinc selenium tea on metabolic syndrome in high-sucrose-high-fat diet-induced obese rats

Effects and Mechanisms of Tea and Its Bioactive Compounds for the Prevention and Treatment of Cardiovascular Diseases: An Updated Review

Effects of green tea consumption on glycemic control: a systematic review and meta-analysis of randomized controlled trials

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