The protective effect of zinc selenium tea against metabolic syndrome (MetS) was tested by using a high-sucrose-high-fat diet (HSHFD)-induced MetS model. Fifty Sprague–Dawley rats were randomly divided into five groups: normal diet (C-group), HSHFD (CH-group), HSHFD + green tea (0.24 g/kg/day) (TH-group), HSHFD + low-dose zinc selenium organic tea (0.24 g/kg/day) (ZTHL-group), and HSHFD + high-dose zinc selenium organic tea (1.20 g/kg/day) (ZTHH-group). After 8 weeks, compared to both the C-group and CH-group, the hepatosomatic index (HI) was significantly reduced in the ZTHL-group (p < 0.05). Fasting blood glucose (FBG) levels were highest in the TH-group, followed by the CH-group, then the ZTHL-group, then the ZTHH-group, and finally the C-group. Compared with the CH-group, the serum total cholesterol (TC) and low density lipid-cholesterol (LDL-C) concentrations were significantly lower in the ZTHH-group (p < 0.05). Significant decreases in serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bile acids (TBA), alkaline phosphatase (ALP), and direct bilirubin (DBIL) levels were observed in ZTHL-group versus the CH-group (p < 0.05). Serum alpha-L-fucosidase (AFU) levels in the ZTHH-group were lower than in the CH-group (P < 0.01). Histopathological examination of the liver and fat biopsies illustrates that the liver cells showed a decrease in the extent of necrosis and dropsy in the ZTHL-group and ZTHH-group versus the CH-group. Zinc selenium tea showed a protection effect against hepatic damage.
We investigated the effects of nonylphenol (NP) on anxiety/depression-like behaviors and alleviation via green tea and zinc selenium (Zn-Se) tea interventions in rats. Forty male specific-pathogen free (SPF) Sprague-Dawley (SD) male rats were randomly divided into four groups (n = 10 per group): control group (C); NP group (40 mg/kg NP); green tea group (40 mg/kg NP + 0.2 g/mL GT group) and Zn-Se tea group (40 mg/kg NP + 0.2 g/mL ZST group). Following tea intervention, compared with the NP group, the residence time in the light-dark box test decreased, and the number of entries into the closed arm in the elevated plus maze test in the tea-treated group was significantly reduced. The sucrose preference index in the sucrose preference test increased, and the immobility time in the forced swimming test decreased. The effect of Zn-Se tea was better than that of green tea. The damage to the hippocampal tissues in the group treated with tea was less than in the NP group. The cellular arrangement was tighter with degeneration, deep staining, and pyknotic nerve cells were visible. The nuclei of the NP group were atrophied, and the cells were sparsely arranged. Compared with the NP group, corticosterone levels were decreased in the NP + Zn-Se tea group. Chronic NP exposure induced anxiety/depression-like behaviors in rats. Green tea effectively reduced the damage to the hippocampal and prefrontal cortex induced by NP. The effects of Zn-Se tea were slightly more optimal than those of conventional green tea.
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