Randomized controlled trial of single-use negative-pressure wound therapy dressings in morbidly obese patients undergoing cesarean delivery

Peterson, Ashley; Bakaysa, Stephanie; Driscoll, Janelle; Kalyanaraman, Rajeshwari; House, Michael

doi:10.1016/j.ajogmf.2021.100410

Cited by 10 publications

(32 citation statements)

References 22 publications

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“…According to the Cochrane Collaboration's tool, five RCTs 17,18,20,22,27 were ranked as high quality and five 21,23–26 as medium quality. The risk of bias assessment summary was presented in Figure 2.…”

Section: Resultsmentioning

confidence: 99%

“…In sensitivity analysis for SSI, there was no significant difference in pooled RR and 95% CI when individual study was removed. In addition, a sensitivity analysis accounting for the quality of included studies was performed, five studies (high quality, low risk of bias) 17,18,20,22,27 showed that NPWT could significantly reduce the occurrence of SSI (pooled RR = 0.76, 95% CI: 0.59–0.97, I 2 = 13%, P = 0.030). There was no significant difference in pooled RR and 95% CI when compared with the results by pooling all included studies.…”

Section: Resultsmentioning

confidence: 99%

“…Eight studies (80.0%) 17,20–23,25–27 included overall wound complications rate as an outcome measure. There was no significant difference in overall wound complications occurrence rate between 11.3% (154/1366) of patients following NPWT and 12.2% (167/1365) following standard dressings (RR = 0.93, 95% CI: 0.76–1.14, I 2 = 0%, P = 0.480) (Figure 5).…”

Section: Resultsmentioning

confidence: 99%

“…Six studies (60.0%) 17,18,20,21,23,26 reported data on blistering. we found that 6.6% (143 of 2183) of the patients receiving NPWT developed skin blistering compared with 1.5% (241 of 2792) of patients receiving standard dressings, NPWT could significantly increase the occurrence of skin blistering with a pooled RR of 4.60 (95% CI: 1.07–19.78, I 2 = 83%, P = 0.040).…”

Section: Resultsmentioning

confidence: 99%

“…Six studies (60.0%) 17,18,20,21,23,26 reported data on blistering. we found that 6.6% (143 of 2183) of the patients receiving NPWT 3).…”

Section: Adverse Skin Reactionsmentioning

confidence: 99%

See 4 more Smart Citations

Prophylactic negative pressure wound therapy on surgical site infection in obese women after cesarean section: A systematic review and meta‐analysis

Guo

Cheng

2021

Intl J Gynecology & Obste

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Cesarean section (CS) is the most common obstetrical surgery worldwide. Rates of cesarean section have risen as a result of numerous factors in recent years. 1,2 Obesity, defined as body mass index (BMI) ≥30, has become a common medical comorbidity of pregnancy affecting approximately one-third of reproductive-aged women in both developed and developing countries according to the World Health Organization (WHO). 3 Previous studies have reported that obese women (BMI ≥ 30) undergoing cesarean section are at increased risk of developing postoperative surgical site occurrences (SSOs), which include surgical site infection (SSI), hematoma, seroma, wound dehiscence and other wound complications. 4 The incidence of SSOs ranges from 3% to 15%. 5,6 The onset of SSOs can result in serious consequences, particularly among women with obesity. These wound complications, especially SSIs, can increase the length of hospital stay, in-hospital mortality, medical costs and delay wound healing, resulting in poor quality of life. 7 Recently, negative pressure wound therapy (NPWT) has emerged as a potential procedure for postoperative management of surgical incision primary closure. Initially introduced by Argenta and Morykwas in the mid-1990s, NPWT has developed and is currently

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Six studies (60.0%) 17,18,20,21,23,26 reported data on blistering. we found that 6.6% (143 of 2183) of the patients receiving NPWT 3).…”

Section: Adverse Skin Reactionsmentioning

confidence: 99%

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Prophylactic negative pressure wound therapy on surgical site infection in obese women after cesarean section: A systematic review and meta‐analysis

Guo

Cheng

2021

Intl J Gynecology & Obste

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A systematic review with meta‐analysis on prophylactic negative pressure wound therapy versus standard dressing for obese women after caesarean section

Tian

Ling

2023

Nursing Open

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AimsThe purpose of this study is to assess the efficacy of prophylactic negative pressure wound therapy (NPWT) in obese women undergoing caesarean section.DesignAn updated review and meta‐analysis of randomized controlled trials following Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines.MethodsPubMed, Embase, Medline, Web of Science, and Cochrane Library were searched from inception up to March 2022 without restriction in language. We chose surgical site infection as the primary outcome.ResultsNPWT resulted in a lower surgical site infection rate compared with conventional dressing (risk ratio [RR] = 0.76). The infection rate after low transverse incision was lower comparing the NPWT group with the control group ([RR] = 0.76). No statistically significant difference was detected in blistering([RR] = 2.91). The trial sequential analysis did not support the 20% relative decrease in surgical site infection in the NPWT group. (type II error of 20%).

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Prophylactic negative pressure wound therapy on wound complications after cesarean delivery in women with obesity: a meta-analysis of randomized controlled trials

Angarita

Jayakumaran

Mascio

et al. 2022

American Journal of Obstetrics & Gynecology MFM

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Randomized controlled trial of single-use negative-pressure wound therapy dressings in morbidly obese patients undergoing cesarean delivery

Cited by 10 publications

References 22 publications

Prophylactic negative pressure wound therapy on surgical site infection in obese women after cesarean section: A systematic review and meta‐analysis

Prophylactic negative pressure wound therapy on surgical site infection in obese women after cesarean section: A systematic review and meta‐analysis

A systematic review with meta‐analysis on prophylactic negative pressure wound therapy versus standard dressing for obese women after caesarean section

Prophylactic negative pressure wound therapy on wound complications after cesarean delivery in women with obesity: a meta-analysis of randomized controlled trials

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