Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome

Wu, Changchun; Wong, Lee-Chin; Hsu, Chia-Jui; Yang, Chianne-Wen; Tsai, Ying-Chieh; Cheng, Feng-Shiang; Hu, Hsiao-Yun; Lee, Wang-Tso

doi:10.3390/nu13113698

Cited by 14 publications

(33 citation statements)

References 42 publications

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“…TS is a neurological disorder that generally develops at the age of 6–18 years. In this syndrome, patients show repetitive behavior like unwanted sounds (tics), repetitive blinking of eyes, abnormal muscle activity, anxiety, and random mood swings [1, 2]. TS has a significant impact on a patient’s mental health and social behavior.…”

Section: Discussionmentioning

confidence: 99%

“…for the treatment of TICS. Various reviews and meta-analyses [1][2][3][4][5] reported the safe and efficient use of these TCMs to treat TICS associated with Tourette Syndrome (TS) with minimal side effects. However, the evidence regarding the TCMs' effectiveness and safety in the treatment of TS is still conflicting due to the limited number of results reported, use of unblinded assessments, lack of sophisticated analysis, and evidencelevel GRADE assessment.…”

Section: Introductionmentioning

confidence: 99%

“…TS, also known as motor or vocal tics, is a common neurological disorder that develops in children of aged 6–18 years. In this syndrome, patients show repetitive behavior like unwanted sounds (tics), repetitive blinking of eyes, abnormal muscle activity, anxiety, and random mood swings [1, 2] as shown in Figure 1. If tics are detected at an early age, then they can be treated by self-care, psychological therapies, and medication therapies, and their associated symptoms can be treated.…”

Section: Introductionmentioning

confidence: 99%

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Is Traditional Chinese Medicine Effective in Treating Tic Disorders (Tourette Syndrome)? A Meta-Analysis of Randomized Controlled Trials

Kang¹,

Li²

2022

Complement Med Res

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Background: Traditional Chinese medicine (TCM) is a type of alternative medicine that has been widely utilized in the prevention and treatment of mental diseases such as schizophrenia, ADHD, Alzheimer's disease, and Tourette's syndrome (TS) in many countries. However, the evidence regarding TCM's effectiveness and safety in treating TS are conflicting. Therefore, the goal of the present study is to analyze and summarize the available literature related to the efficacy of TCM in the treatment of TIC disorders especially, TS. Materials and Methods: Relevant articles for the meta-analysis were searched using appropriate keywords from PubMed, MEDLINE, and CENTRAL databases. Event data for TCM for the treatment of TS in the control and intervention arms were determined from the RCTs, and Diagnostic odds ratio and risk of bias analysis were performed. Meta-analysis was performed using MedCalc software, and suitable parameters to assess heterogeneity were computed. Results: Twelve randomized clinical trials with a total of 1681 Tourette syndrome patients were included as per the inclusion criteria. The patient's clinical symptoms were improved to a greater extent, and the pooled diagnostic odds ratio (DOR) of 1.311 with a 95% confidence interval (CI) value ranging from 0.804 to 2.139 I2 value of 72.04 % was obtained. The pooled relative risk was 1.09, with a 95%CI value ranging from 0.97 to 1.268. The data heterogeneity was assessed, and we achieved the Q value of 33.54, p-value 0.0004, and I2 value of 67.21% with a 95% CI value of 32.91 to 82.10. All these values are statistically significant, with p <0.005, and confirmed the effectiveness of TCM for TICS patients Conclusion: The present meta-analysis on account of these statistically significant results highly recommends using traditional Chinese medicine (TCM) to treat Tourette syndrome.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Is Traditional Chinese Medicine Effective in Treating Tic Disorders (Tourette Syndrome)? A Meta-Analysis of Randomized Controlled Trials

Kang¹,

Li²

2022

Complement Med Res

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“…However, given that this study was based on participant self-reports, more study on this topic is necessary. The treatment of tics with the addition of certain foods or supplements has also been attempted, such as probiotics, N-acetyl cysteine, and omega-3 fatty acids, but results have generally not shown significant improvements [ 73 , 74 , 75 ]. One open-label study did show improvement in tics in patients given L-Theanine and Vitamin B6 as compared with a control condition of psychoeducation [ 76 ].…”

Section: “Just the Facts Ma’am” What’s The Evidence About What Situat...mentioning

confidence: 99%

Why Tic Severity Changes from Then to Now and from Here to There

Iverson

Black

2022

JCM

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Much of the research regarding Tourette’s syndrome (TS) has focused on why certain individuals develop tics while others do not. However, a separate line of research focuses on the momentary influences that cause tics to increase or decrease in patients who are already known to have TS or another chronic tic disorder (CTD). Environmental and internal variables such as fatigue, anxiety, and certain types of thoughts all have been shown to worsen tic severity and may even overcome the positive effects of treatment. Other influences such as stress, distraction, and being observed have had mixed effects in the various studies that have examined them. Still, other variables such as social media exposure and dietary habits have received only minimal research attention and would benefit from additional study. Understanding the impact of these environmental and internal influences provides an opportunity to improve behavioral treatments for TS/CTD and to improve the lives of those living with these conditions. This review will examine the current literature on how these moment-to-moment influences impact tic expression in those with TS/CTD.

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“…Probiotic drugs, in the form of feed additives, are increasingly used in the fattening of animals and poultry for therapeutic and prophylactic purposes (Martyshuk et al, yeast, etc. (Ashayerizadeh et al, 2009;Molnar et al, 2011;Wieërs et al, 2020;Wu et al, 2021;Wan et al, 2021). Their action is based on the high activity of these strains of microorganisms to pathogenic and opportunistic microflora (even insensitive to many antibiotics), the ability to activate macrophages, and the induction of interferons (Griggs & Jacob, 2005;Ushakova et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Blood indices and immune organs morphological structure of broiler chickens under the influence of different doses of probiotic feed additives

Zhyla

Shkodyak

Pyatnychko

et al. 2022

Ukr. Jour. of Vet. and Agr. Sci.

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In the development of effective methods of prevention and treatment of poultry today, importance is given to probiotics based on microbial cultures, in particular, lactobacilli, bifidobacteria, yeast, etc. In contrast to antibiotics, the use of probiotics stimulates the immune response of animals, restores the microflora of the gastrointestinal tract, and ensures its optimal ratio. At the same time, livestock products remain safe for the consumer. The purpose of our work was to conduct comparative clinical trials of the efficiency of the probiotic feed additive Probion-forte in terms of productivity, blood indices, and histological structure of immune organs of chicken broilers during fattening. The clinical studies were carried out with broiler chickens of “Cobb-500” cross at the age of 2 days, which were formed into four groups (300 units in each one). In order to determine the efficiency of application, probiotic feed additives were given to chickens in different concentrations during the growing period, together with the main diet. The first group (1st) was given probiotic Probion-forte in the dose of 1 g/kg of feed, the second group (2nd) – Probion-forte in a dose of 0.5 g/kg, the third (3rd) one – a probiotic-analog “Bio plus 2B” in a dose of 0.4 g/kg; the forth (4th) group was a control group – chickens received an essential diet, without adding any feed additives. The compound feed was provided according to norms recommended for the cross “Cobb-500”, considering age. On the 15th, 30th, and 43rd day of the test, 20 units were selected for hematological, pathomorphological and microbiological tests. The productivity of birds of all studied groups was evaluated by the average daily gains, safety, feed conversion, and slaughter output. The stabilized with EDTA chicken blood was used for morphological studies, and blood serum – for biochemical and immunological studies. Comparative clinical studies have shown that adding to the main diet of broiler chickens probiotic feed additive Probion-forte at a dose of 0.5 and 1.0 g/kg throughout the growing period increases the safety and improves feed digestibility, and increases the bird’s European Efficiency Index. Based on the obtained hematological, biochemical, and immunological parameters of blood, it can be argued about the activating effect on the body of broiler chickens probiotic feed additives, namely the intensification of reanimation of free amino acids, which increases the content of the studied metabolites of lipid metabolism, which chickens use as energy and plastic material. Stimulating cellular and humoral protection, nonspecific resistance is established, confirmed by a high level of lysozyme activity in blood serum and significantly higher content of T- and B-lymphocytes, NK-cells, and γ-globulins. The macro- and microscopic structure of the studied immune organs is preserved in all groups of broiler chickens. Compared with the control group, morphometric examination in the immune organs of broiler chickens of the first and second groups revealed an increase in the area and density of lymphoid elements, an increase in the number of plasmablasts and plasma cells, much higher structural and functional capacity of cells, which was reflected at the ultrastructural level. The most significant difference was found in the 1st group of chickens fed with the feed additive Probion-forte at a dose of 1.0 g/kg of feed.

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Randomized Controlled Trial of Probiotic PS128 in Children with Tourette Syndrome

Cited by 14 publications

References 42 publications

Is Traditional Chinese Medicine Effective in Treating Tic Disorders (Tourette Syndrome)? A Meta-Analysis of Randomized Controlled Trials

Is Traditional Chinese Medicine Effective in Treating Tic Disorders (Tourette Syndrome)? A Meta-Analysis of Randomized Controlled Trials

Why Tic Severity Changes from Then to Now and from Here to There

Blood indices and immune organs morphological structure of broiler chickens under the influence of different doses of probiotic feed additives

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