Randomized Controlled Study of Ocular Lubrication Versus Bandage Contact Lens in the Primary Treatment of Recurrent Corneal Erosion Syndrome

Ahad, Muhammad A.; Anandan, M; Tah, Vikas; Dhingra, Sumit; Leyland, Martin

doi:10.1097/ico.0b013e31829dec39

Cited by 32 publications

(19 citation statements)

References 9 publications

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“…The current available noninvasive conventional treatments for PEDs include the administration of lubricating agents, hyperosmotic agents, autologous serum, and umbilical cord serum, as well as the application of therapeutic contact lenses [4][5][6][7][8]. Surgical treatments include debridement, keratectomy, and amniotic membrane transplantation [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Effect of epidermal growth factor ointment on persistent epithelial defects of the cornea

Moon

Yoon

et al. 2020

BMC Ophthalmol

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Background: Healthy corneal epithelium acts as a barrier against damage to the deeper structures in the eye. Failure in the mechanisms of corneal epithelization can lead to persistent epithelial defects of the cornea (PEDs) and can compromise its function. Epidermal growth factor (EGF) promotes the proliferation, migration, and differentiation of epithelial cells, endothelial cells, and fibroblasts during wound healing and may be beneficial in treating patients with PEDs. We, therefore, investigated the effect of EGF ointment on patients with PEDs. Methods: Fifteen patients with PEDs refractory to conventional treatment were treated twice a day with EGF ointment. Patient demographics and comorbidities were noted. The epithelial healing time was determined along with the primary outcome measures in the areas of the epithelial defects, visual acuity, visual analog scale (VAS) scores, and esthesiometer scores 1 month and 2 months after treatment.Results: Five eyes of herpetic keratitis (33.3%), 3 eyes of dry eye disease (20.0%), 3 eyes of bacterial keratitis (20.0%), 2 eyes of limbal stem cell deficiency (13.3%), 1 eye of diabetic neurotrophic keratitis (6.7%), and 1 eye of filamentary keratitis (6.7%) were associated with PEDs, respectively. Two months following treatment with EGF ointment, there was a reduction in the area of the epithelial defects (5.7 ± 3.9 to 0.1 ± 0.3 mm 2 ) as well as a significant improvement in best-corrected visual acuity (0.9 ± 0.8 to 0.6 ± 0.5 LogMAR) and VAS scores (4.5 ± 1.2 to 2.5 ± 0.7) in 12 eyes (80%). Among these cases, the mean epithelial healing time was 5.5 ± 1.8 weeks. Amniotic membrane transplantation was performed on the remaining 3 (20.0%) patients that did not respond to EGF treatment.Conclusions: EGF ointment could reduce symptoms and promotes corneal epithelialization of refractory PEDs. It may, therefore, be well-tolerated and a potentially beneficial addition in the management of refractory PEDs.

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Section: Introductionmentioning

confidence: 99%

Effect of epidermal growth factor ointment on persistent epithelial defects of the cornea

Moon

Yoon

et al. 2020

BMC Ophthalmol

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“…Therefore, producers recommend that they should be exchanged every 4 if not 2 weeks. A prospective trial of contact lenses versus lubrication in patients with RCE found that contact lenses were inferior and showed a higher complication rate [33]. The authors do recommend the use of BCL for RCE that does not respond to conservative therapy for up to 1-2 months.…”

Section: Measures To Treat Recalcitrant Corneal Erosionsmentioning

confidence: 96%

Recurrent Corneal Erosions in Corneal Dystrophies: a Review of the Pathogenesis, Differential Diagnosis, and Therapy

Omari

2018

Klin Monatsbl Augenheilkd

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“…Ahad et al performed a randomized controlled trial in 29 patients with RCE syndrome, comparing silicone hydrogel bandage contact lenses (extended-wear, replaced every 30 days for a total of 3 months) and ocular lubricants (artificial tears 4 times per day and ointment at bedtime for a total of 3 months) [14]. They found that each intervention had similar efficacy in terms of symptom resolution (10 of 14 patients achieved symptom resolution with contact lenses versus 11 of 15 with ocular lubricants), although there was earlier resolution in the bandage contact lens group (mean time to resolution of 5 weeks versus 9 weeks in the lubrication group, p = 0.02) [14].…”

Section: Contact Lenses In the Management Of Corneal Dystrophiesmentioning

confidence: 99%

Contact Lenses in the Management of Corneal Dystrophies

Farooq

Colby

2019

Klin Monatsbl Augenheilkd

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Among the group of diseases comprising corneal dystrophies, there are a number for which contact lenses may be considered. For example, soft contact lenses may be beneficial in the management of recurrent corneal erosions and advanced bullous keratopathy and may lead to disease attenuation in some conditions. They also may be used in conjunction with surgical procedures to promote tissue healing and patient comfort in the postoperative period. Rigid contact lenses may be beneficial in the setting of irregular astigmatism. The present review of the literature will discuss the use of contact lenses in the management of corneal dystrophies.

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Randomized Controlled Study of Ocular Lubrication Versus Bandage Contact Lens in the Primary Treatment of Recurrent Corneal Erosion Syndrome

Abstract: BCLs do not increase the likelihood of complete resolution when compared with OLs in the initial management of RCES. However, BCL treatment seems safe, and some patients experience earlier relief from symptoms.

Cited by 32 publications

References 9 publications

Effect of epidermal growth factor ointment on persistent epithelial defects of the cornea

Effect of epidermal growth factor ointment on persistent epithelial defects of the cornea

Recurrent Corneal Erosions in Corneal Dystrophies: a Review of the Pathogenesis, Differential Diagnosis, and Therapy

Contact Lenses in the Management of Corneal Dystrophies

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