Randomized, Controlled Study of Innovative Spray Formulation Containing Ozonated Oil and α-Bisabolol in the Topical Treatment of Chronic Venous Leg Ulcers

Abstract

The innovative spray formulation of ozonated oil and α-bisabolol combination shows promise as an important new therapeutic option in the adjuvant treatment of venous ulcers.

Ozone therapy for the treatment of chronic wounds: A systematic review

“…Marfella et al demonstrated a 50% decrease in biochemical markers that prevent healing with ozone compared with 7% in the control group. Four studies focused on the amount of ulcer closure and general appearance of the wound; these studies found a 24%, 50%, and 25% difference in favour of the ozone treatment. Zang et al found that ozone increased closure of ulcers by an average of 3.65 cm 2 compared with the control.…”

“…One study blew an oxygen‐ozone mixture directly into the cavity using a catheter and found an 85% wound closure rate compared with the 71% in the control group ( P = .05) . Of the 2 studies that used ozonised oil as a treatment method, Campanati et al demonstrated a significant ( P = .003) improvement in wound healing compared with the control, and Solovăstru. 2015 25% wound closures compared with the control, and the results were also statistically significant ( P = .05) (Tables and ).…”

“…The mean age of participants in 7 of the 9 trials varied between 50 and 70 years, with the exclusion of Turcić et al, and Solovastru et al, where the mean age of participants ranged between 18 and 30 years and over 18 years, respectively. Five of the trials were conducted in Italy, 2 in China, 1 in Israel, and 1 in Croatia . An inclusion criterion for 5 trials was that the individuals presented with severe ulcerations from poor perfusion .…”

“…Five of the trials were conducted in Italy, 2 in China, 1 in Israel, and 1 in Croatia . An inclusion criterion for 5 trials was that the individuals presented with severe ulcerations from poor perfusion . In 2 of the trials, patients were classified with a Wagner stage 2, 3, or 4 diabetic foot ulcer (Tables and ) .…”

“…Ozone (O 3 ) has been acknowledged as a potent antimicrobial agent since the 1800s . Evidence supports ozone as an advanced clinical therapeutic agent for the treatment of chronic wounds, including ulcers, with significant improvements in healing outcomes .…”