Dressings and topical agents for treating venous leg ulcers

Norman, Gill; Westby, Maggie J; Rithalia, Amber; Stubbs, Nikki; Soares, Marta; Dumville, Jo C

doi:10.1002/14651858.cd012583.pub2

Cited by 82 publications

(64 citation statements)

References 300 publications

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“…Physicochemical properties of the Ag-Si/Al 2 O 3 sorbents presented on Table 2 were calculated by Rachkovskaya et al [41]. It can be seen that the proportion of loaded content of Ag present in the sorbent quantified by optical emission spectroscopy (ICP-OES) from this study, where sample content is 0.01% Ag with the exception of sorbent Ag-Si/Al 2 O 3 -2 (0.003% Ag), the content of Ag in samples is related to its antimicrobial activity [14][15][16]. In the case of the particle sizes was assessed by screen size gradation (0.1-1 mm) [41], being an important parameter for water absorption, due to a reported relationship between the increment of particle size decreases mechanical parameters and increases water absorption [60], the sorbents from this work possess high particle size expecting adequate ability for water uptake.…”

Section: Water Uptake Testmentioning

confidence: 69%

Electrospun Fibers and Sorbents as a Possible Basis for Effective Composite Wound Dressings

et al. 2020

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Skin burns and ulcers are considered hard-to-heal wounds due to their high infection risk. For this reason, designing new options for wound dressings is a growing need. The objective of this work is to investigate the properties of poly (ε-caprolactone)/poly (vinyl-pyrrolidone) (PCL/PVP) microfibers produced via electrospinning along with sorbents loaded with Argovit™ silver nanoparticles (Ag-Si/Al2O3) as constituent components for composite wound dressings. The physicochemical properties of the fibers and sorbents were characterized using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR) and inductively coupled plasma optical emission spectroscopy (ICP-OES). The mechanical properties of the fibers were also evaluated. The results of this work showed that the tested fibrous scaffolds have melting temperatures suitable for wound dressings design (58–60 °C). In addition, they demonstrated to be stable even after seven days in physiological solution, showing no macroscopic damage due to PVP release at the microscopic scale. Pelletized sorbents with the higher particle size demonstrated to have the best water uptake capabilities. Both, fibers and sorbents showed antimicrobial activity against Gram-negative bacteria Pseudomona aeruginosa and Escherichia coli, Gram-positive Staphylococcus aureus and the fungus Candida albicans. The best physicochemical properties were obtained with a scaffold produced with a PCL/PVP ratio of 85:15, this polymeric scaffold demonstrated the most antimicrobial activity without affecting the cell viability of human fibroblast. Pelletized Ag/Si-Al2O3-3 sorbent possessed the best water uptake capability and the higher antimicrobial activity, over time between all the sorbents tested. The combination of PCL/PVP 85:15 microfibers with the chosen Ag/Si-Al2O3-3 sorbent will be used in the following work for creation of wound dressings possessing exudate retention, biocompatibility and antimicrobial activity.

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Section: Water Uptake Testmentioning

confidence: 69%

Electrospun Fibers and Sorbents as a Possible Basis for Effective Composite Wound Dressings

et al. 2020

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“…(Game and Jeffcoate, 2016;Pagnamenta, 2017;. The need for high quality randomized controlled trials on the effectiveness of dressing products with further evidence synthesis, including systematic reviews, overviews of reviews and network metaanalysis, are warranted (Dumville et al, 2013c;Wu et al, 2015;Moore and Webster, 2018;Norman et al, 2018). However, there are many challenges related to evidence generation in wound care , including dressing selection (Pagnamenta, 2017).…”

Section: Discussionmentioning

confidence: 99%

First-Line Interactive Wound Dressing Update: A Comprehensive Review of the Evidence

2020

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Wound management is a significant and growing issue worldwide. Knowledge of dressing products and clinical expertise in dressing selection are two major components in holistic wound management to ensure evidence-based wound care. With expanding global market of dressing products, there is need to update clinician knowledge of dressing properties in wound care. Optimal wound management depends on accurate patient assessment, wound diagnosis, clinicians' knowledge of the wound healing process and properties of wound dressings. We conducted a comprehensive review of the physical properties of wound dressing products, including the advantages and disadvantages, indications and contraindications and effectiveness of first-line interactive/bioactive dressing groups commonly used in clinical practice. These include semipermeable films, foams, hydroactives, alginates, hydrofibers, hydrocolloids, and hydrogels. In making decisions regarding dressing product selection, clinicians need to ensure a holistic assessment of patient and wound etiology, and understand dressing properties when making clinical decisions using wound management guidelines to ensure optimal patient outcomes. This review has highlighted there is lack of high quality evidence and the need for future well designed trials.

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“…The combination of wound dressings and multiple lamination treatments may exert the best therapeutic effect. At the meantime, a network metaanalysis show that silver-containing dressings can increase the likelihood of VLU healing, but because of the small number of related studies and high risk of bias, the most effective treatment is still not determined (Norman et al, 2018). This results of this network meta-analysis focus exclusively on complete healing, did not take other important outcomes into consideration.…”

Section: Chronic Venous Leg Ulcers (Vlu)mentioning

confidence: 99%

Selection of Appropriate Wound Dressing for Various Wounds

Shi

Wang

et al. 2020

Front. Bioeng. Biotechnol.

284

157

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There are many factors involved in wound healing, and the healing process is not static. The therapeutic effect of modern wound dressings in the clinical management of wounds is documented. However, there are few reports regarding the reasonable selection of dressings for certain types of wounds in the clinic. In this article, we retrospect the history of wound dressing development and the classification of modern wound dressings. In addition, the pros and cons of mainstream modern wound dressings for the healing of different wounds, such as diabetic foot ulcers, pressure ulcers, burns and scalds, and chronic leg ulcers, as well as the physiological mechanisms involved in wound healing are summarized. This article provides a clinical guideline for selecting suitable wound dressings according to the types of wounds.

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Dressings and topical agents for treating venous leg ulcers

Cited by 82 publications

References 300 publications

Electrospun Fibers and Sorbents as a Possible Basis for Effective Composite Wound Dressings

Electrospun Fibers and Sorbents as a Possible Basis for Effective Composite Wound Dressings

First-Line Interactive Wound Dressing Update: A Comprehensive Review of the Evidence

Selection of Appropriate Wound Dressing for Various Wounds

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