Randomized controlled study of a novel triple nitazoxanide (<scp>NTZ</scp>)‐containing therapeutic regimen versus the traditional regimen for eradication of <i>Helicobacter pylori</i> infection

Shehata, Mona A. H.; Talaat, Raghda; Soliman, Samah; Elmesseri, Huda; Soliman, Shimaa E.; Abd-Elsalam, Sherief

doi:10.1111/hel.12395

Cited by 36 publications

(26 citation statements)

References 13 publications

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“…There were few prior studies using high‐dose metronidazole (ie, 1500 or 1600 mg) or clarithromycin/high‐dose metronidazole triple therapy. We therefore based the estimation on triple therapy using standard metronidazole doses which were 59%‐82% or the addition of bismuth to either metronidazole or clarithromycin triple therapy which was 94.9%‐96.9% . Assuming an average of 71% eradication rate in ECM group, while 95.9% in BECM group, α‐error of 0.05 (two‐sided), a β‐error of 0.20.…”

Section: Methodsmentioning

confidence: 99%

Bismuth improves efficacy of proton‐pump inhibitor clarithromycin, metronidazole triple Helicobacter pylori therapy despite a high prevalence of antimicrobial resistance

Long

Chen

et al. 2018

Helicobacter

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Section: Methodsmentioning

confidence: 99%

Bismuth improves efficacy of proton‐pump inhibitor clarithromycin, metronidazole triple Helicobacter pylori therapy despite a high prevalence of antimicrobial resistance

Long

Chen

et al. 2018

Helicobacter

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“…H. pylori are prevalent throughout the world but are more prevalent in developing countries [2,3]. This infection is also present more in elderly persons than adolescents [4].…”

Section: Introductionmentioning

confidence: 99%

Association Between Vitamin D Receptor Gene Polymorphisms and Helicobacter Pylori Infection

Mohamed¹,

Moussa²,

Shaheen³

et al. 2020

TOBIOMJ

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Background & Aims: Human genetic polymorphism has been reported in the susceptibility and clinical development of infection. In this regard, this study aimed to investigate the link between Vitamin D Receptor (VDR) gene polymorphism and H. pylori infection. Materials and Methods: This cross-sectional study was conducted on 224 adult patients with upper gastrointestinal symptoms who underwent an upper gastrointestinal endoscopy between July 2017 and May 2019 in two major university hospitals. All patients were evaluated for helicobacter pylori infection. Two gastric antral biopsy specimens were taken from each patient. One of those Biopsy specimens was evaluated for histopathology examination and the other one was immersed in a saline solution ready for genomic DNA extraction. Results: There were statistically significant differences between different genotypes of VDR rs7975232 polymorphism between H. pylori infected and non-infected groups (CC was higher in H. pylori negative and AC and AA were the most common in H. pylori positive group). There were statistical differences between different genotypes of VDR rs2228570 between H. pylori infected and non-infected groups (TT was higher in H. pylori negative and CT and CC were the most common in H. pylori positive group). Regarding VDR rs 7975232 gene polymorphisms; the (A) allele was significantly higher H. pylori infected, while (C) allele was significantly higher in uninfected patients. Regarding VDR rs 2228570 gene polymorphisms; the (C) allele was significantly higher H. pylori infected, while (T) allele was significantly higher in uninfected patients. Conclusion: There is a possible association between the FokI and Apal VDR polymorphism and H. pylori infection.

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“…The CLO test is a examination with speed and easy diagnosis, which indeed obtains the first read in 2 hours after collecting samples by endoscopy. However, the CLO test is prone to produce false‐negative results because of several factors, including a quick reaction of CLO test, the treatment of bismuth, proton‐pump inhibitor (PPI), and antibiotics, peptic ulcer bleeding, and ulcer healing medication . Usually, accurate diagnosis with the CLO test takes more than 24 hours to obtain.…”

Section: Discussionmentioning

confidence: 99%

A time‐saving–modified Giemsa stain is a better diagnostic method of Helicobacter pylori infection compared with the rapid urease test

Fan

Chen

Chou

et al. 2019

Clinical Laboratory Analysis

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This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. Abstract Background: Despite having chronic gastritis, most people infected by Helicobacter pylori (H. pylori) are asymptomatic and have no specific clinical signs and symptoms. H. pylori infection can be diagnosed by several detection methods. Giemsa stain and rapid urease test (CLO test) are the most performed tests of H. pylori infection at first-line clinical examination because of their simplicity and reliability. However, the sensitivity of CLO test is significantly reduced in patients with atrophic gastritis and intestinal metaplasia, and the weaknesses of Giemsa stain are higher cost and time-consuming. Methods: The Giemsa stain was modified in several staining solutions and procedures based on the simplified Giemsa technique described by Gray, Wyatt, & Rathbone (1986). The modified Giemsa stain is examined its efficacy and compared with the CLO test using 233 H. pylori-infected patients with gastric disease. Results:The modified Giemsa stain is comparable to the traditional one. Statistical analysis indicated that the modified Giemsa stain obtains greater accuracy in H. pylori-infected patients with gastritis and ulcer than the CLO test (48.1% vs. 43.7%).Moreover, considering the prognosis of different symptoms of gastric diseases, the modified Giemsa stain has a more accurate prognosis than combination symptoms (P = 1.8E-05 vs. P = 5.49E-05). The modified Giemsa stain is confirmed to be better than CLO test using 233 H. pylori-infected patients with gastric disease. Conclusions:The modified Giemsa stain is more simplified and time-saving than traditional Giemsa stain, which is comparable to the traditional one and is confirmed to be better than CLO test using 233 H. pylori-infected patients with gastric disease. In clinical examination, this modified Giemsa stain can be applied to routine examination and provides quick and accurate diagnosis and prognosis to H. pylori-infected patients with gastric diseases. K E Y W O R D S gastric diseases, H. pylori, histological techniques, new Giemsa stain 2 of 5 | FAN et Al.

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Randomized controlled study of a novel triple nitazoxanide (NTZ)‐containing therapeutic regimen versus the traditional regimen for eradication of Helicobacter pylori infection

Abstract: Nitazoxanide-containing triple therapy is a promising therapy for the first-line eradication of H. pylori. (ClinicalTrials.gov Identifier: NCT02422706).

Cited by 36 publications

References 13 publications

Bismuth improves efficacy of proton‐pump inhibitor clarithromycin, metronidazole triple Helicobacter pylori therapy despite a high prevalence of antimicrobial resistance

Bismuth improves efficacy of proton‐pump inhibitor clarithromycin, metronidazole triple Helicobacter pylori therapy despite a high prevalence of antimicrobial resistance

Association Between Vitamin D Receptor Gene Polymorphisms and Helicobacter Pylori Infection

A time‐saving–modified Giemsa stain is a better diagnostic method of Helicobacter pylori infection compared with the rapid urease test

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