Association Between Vitamin D Receptor Gene Polymorphisms and Helicobacter Pylori Infection

Abstract

Background & Aims: Human genetic polymorphism has been reported in the susceptibility and clinical development of infection. In this regard, this study aimed to investigate the link between Vitamin D Receptor (VDR) gene polymorphism and H. pylori infection. Materials and Methods: This cross-sectional study was conducted on 224 adult patients with upper gastrointestinal symptoms who underwent an upper gastrointestinal endoscopy between July 2017 and May 2019 in two major university hospitals. All patients were evaluated for helicobacter pylori infection. Two gastric antral biopsy specimens were taken from each patient. One of those Biopsy specimens was evaluated for histopathology examination and the other one was immersed in a saline solution ready for genomic DNA extraction. Results: There were statistically significant differences between different genotypes of VDR rs7975232 polymorphism between H. pylori infected and non-infected groups (CC was higher in H. pylori negative and AC and AA were the most common in H. pylori positive group). There were statistical differences between different genotypes of VDR rs2228570 between H. pylori infected and non-infected groups (TT was higher in H. pylori negative and CT and CC were the most common in H. pylori positive group). Regarding VDR rs 7975232 gene polymorphisms; the (A) allele was significantly higher H. pylori infected, while (C) allele was significantly higher in uninfected patients. Regarding VDR rs 2228570 gene polymorphisms; the (C) allele was significantly higher H. pylori infected, while (T) allele was significantly higher in uninfected patients. Conclusion: There is a possible association between the FokI and Apal VDR polymorphism and H. pylori infection.

Association Between Vitamin D Receptor Polymorphism and the Response to Helicobacter Pylori Treatment

“…Together with ethnic characteristics, these interactions—which are crucial for illness development and genetic makeup—were most likely responsible for the disparity in allelic frequencies observed in the research population. The results of Mohamed et al 15 were consistent with the lack of a statistically significant variation in the sex distributions across the various genotypes. This is consistent with our findings.…”

“…According to Mohamed et al’s findings, H. pylori infection and the FokI and Apal VDR polymorphism are related. 15 Additionally, Qadir et al discovered a substantial correlation between the VDR Bsml SNP and increased risk of gastric cancer, particularly in obese individuals. 23 In contrast to Martins et al, 24 who claimed that there were no appreciable changes between patients with H. pylori infection and control groups in terms of the allelic and genotypic distribution of the FokI and ApaI polymorphisms of the VDR gene.…”

“… 14 The FokI and Apal VDR polymorphism and H. pylori infection may go hand in hand. 15 This research aimed to determine how variations in the vitamin D receptor gene affected how H. pylori infections responded to eradication therapy.…”

Vitamin D and Its Association with H. pylori Prevalence and Eradication: A Comprehensive Review

“…The other three polymorphisms studied—namely FokI, ApaI, and TaqI—presented no significant genotype distribution variation among the two study groups [ 54 ]. However, in another study, a significant correlation between the Fokl and Apal polymorphisms of the VDR gene and H. pylori infection was found [ 55 ].…”