Association Between Vitamin D Receptor Polymorphism and the Response to Helicobacter Pylori Treatment

Abstract

Background & Aims This research aimed to determine how variations in the vitamin D receptor gene affected the response of H. pylori infections to eradication therapy. Patients and Methods On 105 adult H. Pylori -positive patients, a prospective cohort study was carried out. PCR was used to genotype all patients’ VDR gene polymorphisms. The patients in the study received standard triple eradication medication (clarithromycin 500 mg, amoxicillin 1000 mg, and omeprazole 20 mg) twice daily for 14 days. A stool test for H. pylori Ag was conducted 4 weeks following the end of treatment. Results In our study, the usual triple therapy’s H. pylori eradication rate was 75.2%. The successful eradication of H. pylori and VDR rs 2228570 gene polymorphisms was more prevalent in CT gene polymorphism (64.6%) compared to non-responders (19.2%), while treatment failure was more prevalent in CC gene polymorphism (73.1% in non-responders compared to responders 24.1%), which is statistically significant. In regards to the eradication of H. pylori and VDR rs7975232 gene polymorphisms, the success of eradication was more prevalent in AC gene polymorphism (54.4%) vs non-responders (30.4%), while all patients (14) with gene AA (17.7%) are responders to standard treatment, while the failure of treatment was more prevalent in CC gene polymorphism (69.2% in non-responder vs 27.8% in responders) which is statistically significant. Our findings demonstrated a strong correlation between patients’ responses to H. pylori treatment and polymorphisms in the VDR gene (ApaI and TaqI) (P 0.05). Conclusion As far as we are aware, this is the first study to identify a potential link between the FokI and Apal VDR polymorphism and treatment response in H pylori -positive patients. To evaluate the findings, more research with larger number of patients and different population is required.

Global knowledge mapping and emerging trends in Helicobacter pylori-related precancerous lesions of gastric cancer research: A bibliometric analysis from 2013 to 2023

“…[ 43 ] In the timeline view of keywords, Cag A, pepsinogen II, GC, and gastric ulcer have been the hotspots of H pylori -related PLGC. The association between virulent H pylori strains and gastric ulcers and cancer is attributed to their ability to induce immune cell infiltration in the gastric mucosa, leading to observable inflammatory responses., [ 44 ] cagA gene-positive H pylori is more prevalent in patients with advanced PLGC, and infection with cagA -positive strains correlates with disease progression. [ 45 ] Active gastritis with high pepsinogen II level and H pylori infection are associated with an increased risk of GC in non-CAG patients with H pylori infection.…”