Randomized clinical trial of tetracycline hydrochloride bandage and paste treatments for resolution of lesions and pain associated with digital dermatitis in dairy cattle

Cutler, Janet Higginson; Cramer, G.; Walter, Julie; Millman, Suzanne T.; Kelton, D.F.

doi:10.3168/jds.2012-6384

Cited by 56 publications

(73 citation statements)

References 24 publications

(32 reference statements)

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“…There is still uncertainty and disagreement regarding the actual efficacy of treatment outcomes with topical therapy. Success rates as low as 9% and as high as 73% have been reported (Berry, Read, Walker, & Famula, ; Cutler, Cramer, Walter, Millman, & Kelton, ; Krull, Shearer et al., ; Laven & Hunt, ; Nishikawa & Taguchi, ; Shearer & Hernandez, ). There is a pressing need for good comparative field studies using robust study designs (ideally prospective randomized controlled trials) to determine the most efficacious treatment approach.…”

Section: Treatmentmentioning

confidence: 99%

“…have been reported (Berry, Read, Walker, & Famula, 2010;Cutler, Cramer, Walter, Millman, & Kelton, 2013;Laven & Hunt, 2001;Nishikawa & Taguchi, 2008;Shearer & Hernandez, 2000). There is a pressing need for good comparative field studies using robust study designs (ideally prospective randomized controlled trials) to determine the most efficacious treatment approach.…”

Section: Treatmentmentioning

confidence: 99%

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Missing pieces of the puzzle to effectively control digital dermatitis

Orsel

Plummer

Shearer

et al. 2017

Transbound Emerg Dis

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Since the first report of bovine digital dermatitis (DD) in 1974, there is a large body of the literature published; however, effective prevention and control of the disease remain elusive. Although many aspects of the pathogenesis of DD have been investigated, even some of the most basic questions such as the aetiology of this disease remain under debate. Treponema spp. have been strongly associated with DD lesions and occur in abundance in advanced lesions; however, efforts to induce disease with pure cultures of these organisms have been largely underwhelming and inconsistent. Furthermore, although the disease has been presented for several decades, there is limited scientific evidence regarding effective treatment of DD. Apparent discrepancies between effectiveness in vitro and in vivo have challenged the scientific community to identify new potential treatment options. With no treatment resulting in a 100% cure rate, the current expectation is manageable control, but prospects for the eradication of the disease are unlikely using current approaches. In order to develop more effective approaches to control DD on-farm, there is a critical need for a deeper understanding regarding the causation, ecology, transmission and treatment of this disease. In this article, we attempt to provide insights into specific research needs related to DD in order to assist the industry, researchers, pharmaceutical companies and research sponsors with decision-making and identified research gaps.

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Section: Treatmentmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

Missing pieces of the puzzle to effectively control digital dermatitis

Orsel

Plummer

Shearer

et al. 2017

Transbound Emerg Dis

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“…In this study, 47.4 per cent and 57.1 per cent were healed at 8–12 days post-treatment, respectively (Cutler and others 2013). These treatments have a much lower cure rate than the 75 per cent cure rate of with topical treatment with oxytetracycline in this study.…”

Section: Discussionmentioning

confidence: 56%

Comparing the curative efficacy of topical treatment with thiamphenicol and oxytetracycline on digital dermatitis lesions in dairy cattle

Holzhauer

Deventer²,

Smits

et al. 2017

Veterinary Record

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The efficacy of two topically applied antibiotics for the treatment of painful ulcerative stage of bovine digital dermatitis (BDD) lesions was compared in a clinical trial conducted on five dairy farms in the Netherlands during the autumn of 2015. A total of 109 cows with an ulcerative (M2) stage of BDD were randomly appointed a treatment with an antibiotic-based spray. One treatment contained thiamphenicol as active ingredient (TAF). The other treatment had oxytetracycline as active ingredient (ENG). The experimental unit for this study was the hind claw with the presence of an ulcerative BDD lesion. On day 0, claws with ulcerative BDD lesions were trimmed, cleaned, photographed and thereafter treated randomly either with TAF or ENG. Cure was defined as the transition of an ulcerative lesion into a non-painful chronic (M4) or into a healed (M0) stage of BDD at day 28 post-treatment. The cure rate at day 28 of M2 BDD lesions treated with TAF was 89 per cent (95 per cent CI 0.78 to 0.94), and for ENG 75 per cent (95 per cent CI 0.67 to 0.86). So the difference in cure rate was 14 per cent (95 per cent CI 0.00 to 0.27), which was statistically significant. The P value in this experiment is very close to 0.05 indicating that the effect is quite small. If a two-sided test would be used, the small significant effect, in this experiment, will disappear. Overall, the significant better curative effect of TAF on BDD M2 lesions was small, compared with ENG.

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“…It was estimated that only this effect translated into an improvement of 1.5 per cent, with added economic benefits from just the reduction of C. perfringens infections without even considering other diseases [92]. In addition, it is worth noting that TCs have been employed also as healing agent for digital dermatitis treatment in dairy cattle [93]. For those reasons, pigs, livestock and poultry are still exposed to a huge range of antimicrobials while the long term effect on the environment, besides antibiotic resistance [94,95], or effects, when consumed by the animal or human species, on the overall individual health status have been partially investigated.…”

Section: Tetracyclines In Veterinary Practicementioning

confidence: 99%

Tetracyclines: Insights and Updates of their Use in Human and Animal Pathology and their Potential Toxicity

Cerbo¹,

Pezzuto²,

Guidetti³

et al. 2019

Open Biochem J.

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Tetracycline antibiotics (TCs) have been widely employed to treat bacterial infections and other pathologic conditions in humans and pets. Although most of TCs have been almost ruled out from the human clinical practice they are still used as growth promoters and to treat promiscuity and overcrowding pathologies in the intensive animal farming. As a consequence, TCs are commonly found in all ecological compartments with potential direct or indirect toxicological effects on animals and, generally, on all living organisms. Moreover, clinical and in vitro observations raised the hypothesis that the widespread of some adverse food reactions and, to a less extent, antibiotic resistance phenomena could be ascribed to the presence of TCs residues in edible and non-edible tissues of intensive animal farming intended for animal and human consumption. Such residues may pose serious health threat, depending on the type of food and the amount of residue present.The aim of this review is to provide new insights about the clinical uses of TCs in humans and animals and their potential toxic effects as residues in the environment or as food components.

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Randomized clinical trial of tetracycline hydrochloride bandage and paste treatments for resolution of lesions and pain associated with digital dermatitis in dairy cattle

Cited by 56 publications

References 24 publications

Missing pieces of the puzzle to effectively control digital dermatitis

Missing pieces of the puzzle to effectively control digital dermatitis

Comparing the curative efficacy of topical treatment with thiamphenicol and oxytetracycline on digital dermatitis lesions in dairy cattle

Tetracyclines: Insights and Updates of their Use in Human and Animal Pathology and their Potential Toxicity

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