Randomized clinical trial of local gentamicin–collagen treatment in advancement flap repair for anal fistula

Abstract

Endoanal advancement flap repair for anal fistula has a fairly high primary recurrence rate. Healing was not significantly improved by local application of gentamicin-collagen.

Closure of Fistula Tract With Filac™ Laser As a Sphincter Preserving Method in Anal Fistula Treatment

“…Bu yöntemlerden bazıları bioprostetik tıkaçlar, anorektal doku flebleri gibi yöntemlerdir. 24,25,26 Ancak bu yöntemler doku iyileşmesini ve fistülün kapanması üzerine istenilen sonuçları verememiş ve fistülün tekrarlamasına engel olamamıştır. Bizim çalışmamızda FiLaC TM lazer radyal uçlu fiber tarafından fistül yoluna gönderilen lazer enerjisi, endolüminal granülasyon dokusunu ve fistül yolunun epitelyal duvarını tahrip eder.…”

TOPICALLY-USED GENTAMICIN ATTACHED TO NANOFIBRE MDOCTM COMPARED WITH GARAMYCIN SCHWAMM^® IN AN ACUTE WOUND INFECTION MODEL. AN EXPERIMENTAL STUDY.

“…In case of a repair of an anal fistula, using advancement flap gentamicin-collagen did not decrease the infection rate, nor was a different reccurence rate observed [17].…”

“…Collagen matrix is fully biodegradable and resorbed within 1 to 8 weeks, depending on the vascularization of the tissue [15,17]. In contrast, micro-dispersed oxidised cellulose is fully resorbed within the first 48 hours in 94 % of wounds.…”

Endorectal Advancement Flap

“…In studies that have shown a difference in healing rates with age, increased age is associated with a higher likelihood of healing. Gustafsson et al found a trend toward a higher likelihood of healing with age greater than 50 [ 28 ]. Similarly, healing rates were 45.7 % for age less than 40, 67.9 % for those aged 40-60, and 100 % for those older than 60 in a paper by Sonoda et al [ 29 ].…”