Randomized Clinical Assay for Hepatic Grafts Preservation With University of Wisconsin or Histidine-Tryptophan-Ketoglutarate Solutions in Liver Transplantion

Meine, M.H.; Zanotelli, Maria Lúcia; Neumann, Joyce; Kiss, Guillermo; Grezzana, T.; Leipnitz, Ian; Schlindwein, Eduardo; Fleck, Alfeu de Medeiros; Gleisner, Ana; Brandão, Ajácio; Marroni, Cláudio Augusto; Cantisani, Guido Pio Gracco

doi:10.1016/j.transproceed.2006.06.071

Cited by 43 publications

(38 citation statements)

References 7 publications

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“…Of note, more biliary complications were seen in the livers preserved with HTK solution [15]. Of note, more biliary complications were seen in the livers preserved with HTK solution [15].…”

Section: Livermentioning

confidence: 89%

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Preservation solutions for static cold storage of abdominal allografts

Parsons

Guarrera

2014

Current Opinion in Organ Transplantation

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“…Of note, more biliary complications were seen in the livers preserved with HTK solution [15]. Of note, more biliary complications were seen in the livers preserved with HTK solution [15].…”

Section: Livermentioning

confidence: 89%

“…Histidine serves as a buffer, tryptophan is a membrane stabilizer, and ketoglutarate is an energy substrate (see Table 2) [9][10][11][12][13][14][15][16][17][18][19]. HTK, which was originally designed as a cardioplegia, is a crystalloid with osmolarity slightly higher than the intracellular space.…”

Section: Introductionmentioning

confidence: 99%

Preservation solutions for static cold storage of abdominal allografts

Parsons

Guarrera

2014

Current Opinion in Organ Transplantation

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“…Large database-derived studies comparing the use of University of Wisconsin solution vs. HTK for organ preservation have shown similar results in terms of patient and graft survival post transplant, especially when the organ cold ischemia period is kept to a minimum [8][9][10][11]. Potential adverse outcomes in these cases include increased risk of graft loss, thrombosis, pancreatitis, and biliary complications [15][16][17][18]. Potential adverse outcomes in these cases include increased risk of graft loss, thrombosis, pancreatitis, and biliary complications [15][16][17][18].…”

Section: Cold Preservation Solutionsmentioning

confidence: 96%

Organ preservation review

Cameron

Cornejo

2015

Current Opinion in Organ Transplantation

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“…To date, UW solution has remained the gold standard solution against which all other solutions are compared [25] . There is no evidence from randomized controlled trials that any of the other solutions such as Celsior solution or histidine-tryptophanketoglutarate solution result in a better graft or patient survival than UW solution [26][27][28][29][30] .…”

Section: Static Cold Storage and Storage Solutionsmentioning

confidence: 99%

Current protective strategies in liver surgery

Gurusamy

González²,

Davidson³

2010

WJG

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During liver resection surgery for cancer or liver transplantation, the liver is subject to ischaemia (reduction in blood flow) followed by reperfusion (restoration of blood flow), which results in liver injury [ischemia-reperfusion (IR) or IR injury]. Modulation of IR injury can be achieved in various ways. These include hypothermia, ischaemic preconditioning (IPC) (brief cycles of ischaemia followed by reperfusion of the organ before the prolonged period of ischaemia i.e. a conditioning response), ischaemic postconditioning (conditioning after the prolonged period of ischaemia but before the reperfusion), pharmacological agents to decrease IR injury, genetic modulation of IR injury, and machine perfusion (pulsatile perfusion). Hypothermia decreases the metabolic functions and the oxygen consumption of organs. Static cold storage in University of Wisconsin solution reduces IR injury and has prolonged organ storage and improved the function of transplanted grafts. There is currently no evidence for any clinical advantage in the use of alternate solutions for static cold storage. Although experimental data from animal models suggest that IPC, ischaemic postconditioning, various pharmacological agents, gene therapy, and machine perfusion decrease IR injury, none of these interventions can be recommended in clinical practice. This is because of the lack of randomized controlled trials assessing the safety and efficacy of ischaemic postconditioning, gene therapy, and machine perfusion. Randomized controlled trials and systematic reviews of randomized controlled trials assessing the safety and efficacy of IPC and various pharmacological agents have demonstrated biochemical or histological improvements but this has not translated to clinical benefit. Further well designed randomized controlled trials are necessary to assess the various new protective strategies in liver resection.

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Randomized Clinical Assay for Hepatic Grafts Preservation With University of Wisconsin or Histidine-Tryptophan-Ketoglutarate Solutions in Liver Transplantion

Cited by 43 publications

References 7 publications

Preservation solutions for static cold storage of abdominal allografts

Preservation solutions for static cold storage of abdominal allografts

Organ preservation review

Current protective strategies in liver surgery

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