Organ preservation review

Cameron, Andrew M.; Cornejo, Jose F. Barandiaran

doi:10.1097/mot.0000000000000175

Cited by 29 publications

(12 citation statements)

References 60 publications

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“…Depending on the ischemia time, reversible and irreversible changes can occur in the mitochondria, endoplasmic reticulum, lysosomes, cell nucleus, and cell membrane. 112–116…”

Section: Cardiac Transplantationmentioning

confidence: 99%

“…Depending on the ischemia time, reversible and irreversible changes can occur in the mitochondria, endoplasmic reticulum, lysosomes, cell nucleus, and cell membrane. [112][113][114][115][116] The main objectives in organ preservation are to establish hypothermia, prevent cell swelling, and minimize free radicalinduced organ injury. Early graft dysfunction, including primary graft dysfunction, is mainly due to preservation injury.…”

Section: Donor Heart Harvest and Preservationmentioning

confidence: 99%

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Pathobiology of Myocardial Ischemia and Reperfusion Injury: Models, Modes, Molecular Mechanisms, Modulation, and Clinical Applications

Buja

2022

Cardiology in Review

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This review presents an integrated approach to the analysis of myocardial ischemia and reperfusion injury and the modulating influence of myocardial conditioning during the evolution of acute myocardial infarction (AMI) and other clinical settings. Experimental studies have involved a spectrum of in vitro, ex vivo, and in vivo models, and guidelines have been developed for the conduct of rigorous preclinical studies and for the identification of various forms of cell injury and death in evolving AMI. AMI in vivo is dominated by oncosis (cell injury with swelling) leading to necroptosis and final necrosis of ischemic cardiomyocytes (CMCs), without or with contraction band formation. Early after coronary occlusion, reperfusion salvages a significant amount of ischemic myocardium in the subepicardium while reperfusion injury contributes up to 50% of the final subendocardial infarct. AMI progression is mediated by damage (or danger)-associated molecular patterns, also known as alarmins, which activate pattern recognition receptors and initiate the inflammatory response. In preclinical studies, lethal reperfusion injury can largely be prevented with preconditioning or postconditioning by pharmacologic or physical means due to effects on both the CMC and microvasculature. Conditioning involves triggers, cytosolic mediators, and intracellular effectors. Mitochondria have a central role in the maintenance and loss of viability of CMCs. Reperfusion of severely ischemic myocardium leads to sustained opening of the mitochondrial permeability transition pore (MPTP). Once the MPTP is opened, the mitochondrial membrane potential (ΔΨm) is rapidly lost and energy production ceases. Conditioning blocks the sustained opening of the MPTP. Translation of conditioning strategies to the clinical management of patients has been challenging. The status of translation of experimental findings to approaches to modulate and ameliorate ischemic and reperfusion injury is discussed for the clinical settings of acute coronary syndromes treated with percutaneous interventions and cardiac preservation during open heart surgery and cardiac transplantation.

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“…Depending on the ischemia time, reversible and irreversible changes can occur in the mitochondria, endoplasmic reticulum, lysosomes, cell nucleus, and cell membrane. 112–116…”

Section: Cardiac Transplantationmentioning

confidence: 99%

Section: Donor Heart Harvest and Preservationmentioning

confidence: 99%

Pathobiology of Myocardial Ischemia and Reperfusion Injury: Models, Modes, Molecular Mechanisms, Modulation, and Clinical Applications

Buja

2022

Cardiology in Review

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“…In turn, alanine is a non-essential amino acid that is involved in the metabolism of tryptophan, which can also be a methyl donor [34,35]. Of note, to the potential ability of these amino acids to make epigenetic changes, their demonstrated protecting function as part of the solution for hypothermic preservation of organs in transplantation could be added [36].…”

Section: The Mast Cell As Mediator Of the Splanchnic Lymphatic Patmentioning

confidence: 99%

The Lymphatic Headmaster of the Mast Cell-Related Splanchnic Inflammation in Portal Hypertension

Aller

Blanco-Rivero

Arias

et al. 2019

Cells

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Portal hypertension is a common complication of liver disease, either acute or chronic. Consequently, in chronic liver disease, such as the hypertensive mesenteric venous pathology, the coexisting inflammatory response is classically characterized by the splanchnic blood circulation. However, a vascular lymphatic pathology is produced simultaneously with the splanchnic arterio-venous impairments. The pathological increase of the mesenteric venous pressure, by mechanotransduction of the venous endothelium hyperpressure, causes an inflammatory response involving the subendothelial mast cells and the lymphatic endothelium of the intestinal villi lacteal. In portal hypertension, the intestinal lymphatic inflammatory response through the development of mesenteric-systemic lymphatic collateral vessels favors the systemic diffusion of substances with a molecular pattern associated with damage and pathogens of intestinal origin. When the chronic hepatic insufficiency worsens the portal hypertensive inflammatory response, the splanchnic lymphatic system transports the hyperplasied intestinal mast cells to the mesenteric lymphatic complex. Then, an acquired immune response regulating a new hepato-intestinal metabolic scenario is activated. Therefore, reduction of the hepatic metabolism would reduce its key centralized functions, such as the metabolic, detoxifying and antioxidant functions which would try to be substituted by their peroxisome activity, among other functions of the mast cells.

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“…For many years, the choice of SCS has dominated clinical organ preservation, but currently there is growing interest once more in dynamic intervention by organ perfusion, driven by many factors, including changing donor demographics and the need to utilize all available organs for transplantation to meet the rising clinical need. Recent publications continue to debate these issues [19-21]. …”

Section: Historical Perspectives Of Organ Preservation For Transplantmentioning

confidence: 99%

“…Each of them has positive and negative features and provides similar storage time of donor organs [19, 81]. There is no consensus about the optimal preservation solution up to now.…”

Section: New Areas Of Focus In Opsmentioning

confidence: 99%

Organ Preservation into the 2020s: The Era of Dynamic Intervention

Petrenko

Carnevale

Somov

et al. 2019

Transfus Med Hemother

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Organ preservation has been of major importance ever since transplantation developed into a global clinical activity. The relatively simple procedures were developed on a basic comprehension of low-temperature biology as related to organs outside the body. In the past decade, there has been a significant increase in knowledge of the sequelae of effects in preserved organs, and how dynamic intervention by perfusion can be used to mitigate injury and improve the quality of the donated organs. The present review focuses on (1) new information about the cell and molecular events impacting on ischemia/reperfusion injury during organ preservation, (2) strategies which use varied compositions and additives in organ preservation solutions to deal with these, (3) clear definitions of the developing protocols for dynamic organ perfusion preservation, (4) information on how the choice of perfusion solutions can impact on desired attributes of dynamic organ perfusion, and (5) summary and future horizons.

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Organ preservation review

Abstract: New trends in organ preservation may soon translate into more efficient use of the limited donor pool.

Cited by 29 publications

References 60 publications

Pathobiology of Myocardial Ischemia and Reperfusion Injury: Models, Modes, Molecular Mechanisms, Modulation, and Clinical Applications

Pathobiology of Myocardial Ischemia and Reperfusion Injury: Models, Modes, Molecular Mechanisms, Modulation, and Clinical Applications

The Lymphatic Headmaster of the Mast Cell-Related Splanchnic Inflammation in Portal Hypertension

Organ Preservation into the 2020s: The Era of Dynamic Intervention

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