Randomised trial of telephone counselling to improve participants' adherence to prescribed drugs in a vascular screening trial

Qvist, Ina; Lindholt, Jes Sanddal; Søgaard, Rikke; Lorentzen, Vibeke; Hallas, Jesper; Frost, Lars

doi:10.1111/bcpt.13459

Cited by 7 publications

(10 citation statements)

References 31 publications

(55 reference statements)

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“…Table 1 shows the characteristics of the studies included in this review, with studies being grouped by intervention type, and by adherence measure. Out of 12 included studies, six had older adults as the population of interest [ 25 – 30 ], one study included only male patients who were 65 to 74 years old [ 31 ], and five included patients 65 years and older as sub-populations [ 32 – 36 ]. Only three studies [ 25 , 27 , 30 ] included patient retention rates for older adults.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, only two [ 33 , 36 ] out of five RCTs had outcome assessors being blinded to treatment assignment. In addition, follow-up was only complete in one study [ 31 ] and differences between groups in terms of their follow-up were not always adequately described or analyzed. In the included cohort studies, follow-up was complete or described and explored if incomplete in only two studies [ 28 , 32 ].…”

Section: Resultsmentioning

confidence: 99%

“…Out of 12 included studies, 10 studies reported that their intervention had a positive effect on adherence [ 25 , 27 – 32 , 34 – 36 ]. One of these studies [ 31 ] reported a positive effect on adherence to statins after 6 months, but no positive effect at 12 and 90 months. Another study [ 27 ] reported a positive effect on adherence only in a sub-group of women who had the electronic reminder in a secondary prevention setting.…”

Section: Resultsmentioning

confidence: 99%

“…Patient education and information : Two studies [ 31 , 33 ] attempted to increase adherence using education-based strategies. The results of Eussen et al [ 33 ] were inconclusive regarding the effect of in-person counseling visits in a pharmacy setting on the incidence of discontinuation therapy in patients aged > 65 years old (HR = 0.903 [95% CI: 0.569–1.433]).…”

Section: Resultsmentioning

confidence: 99%

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Strategies aiming to improve statin therapy adherence in older adults: a systematic review

Frieden,

Gagnon,

Bénard

et al. 2024

BMC Geriatr

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Background Randomized clinical trials have shown that, under optimal conditions, statins reduce the risk of cardiovascular events in older adults. Given the prevalence and consequences of suboptimal adherence to statin among older adults, it is essential to document strategies designed to increase statin adherence in this population. The objective of this systematic review is to describe and summarize the effectiveness of interventions to improve statin adherence in older adults (≥ 65 years old). Methods This review followed PRISMA guidelines. Studies were identified from PubMed, PsycINFO, Embase, CINAHL and Web of Science. Study selection was conducted independently by four reviewers working in pairs. Included studies reported data on interventions designed to increase adherence to statin therapy in older adults and were original trials or observational studies. Interventions were pragmatically regrouped into 8 different categories going from patient to administrative level. Two reviewers extracted study data and assessed study quality independently. Given the heterogeneity between the included studies, a narrative critique and summary was conducted. Results Twelve out of the 2889 identified articles were included in the review. Our review showed that simplifying patients’ drug regimen, administrative improvements and large-scale pharmacy-led automated telephone interventions show positive effects on patient adherence to statin therapy, with odds ratios between > 1.0 and 3.0, while education-based strategies and intensified patient care showed mixed results. Conclusions Current evidence suggests that some interventions can increase statin adherence in older adults, which could help in the reduction of the risk of a cardiovascular event in this population.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Strategies aiming to improve statin therapy adherence in older adults: a systematic review

Frieden,

Gagnon,

Bénard

et al. 2024

BMC Geriatr

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“…In several studies, MA improved in the short term; however, this improvement was not persistent over time, and people stopped using the telepharmacy intervention over time. Studies associated this decline with poor long-term commitment to the interventions [17,31,34]. For instance, following up on the older HIV patients using mobile app reminders for 48 weeks showed no change in MA [54], and in another study, cancer patients showed only shortterm improvements in adherence to medications when using a mobile app [43].…”

Section: User Behavior and Perceptionsmentioning

confidence: 99%

Factors affecting medication adherence among older adults using tele-pharmacy services: a scoping review

Emadi

Ghanbarzadegan²,

Ghahramani³

et al. 2022

Arch Public Health

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Background Medication adherence among older adults (aged 60 and above), particularly those with chronic conditions who take several medications, is critical, and tele-pharmacy services are a way to improve medication adherence. This study sought to determine the factors influencing medication adherence (MA) in older adults using tele-pharmacy services. Method The Joana Briggs Institute scoping review methodology was implemented. Searches were conducted in databases PubMed, Scopus, ProQuest, Web of Science, and Embase from 2000 to the present day, to identify both qualitative and quantitative studies focusing on the use of tele-pharmacy by older people. Factors impacting MA were extracted and analyzed into themes using a qualitative approach. A concept map was also designed summarising these factors. Results Of 7495 articles obtained in the initial search, 52 articles met the inclusion criteria. The analysis resulted in 5 themes and 21 sub-themes representing factors that impacted MA with tele-pharmacy. These themes are divided broadly into technology and user related factors. Technology factors included design of the tele-pharmacy intervention, commercial aspects, and adherence measurement method. User factors included user-health constraints, behaviors and perceptions. Conclusion Industry, policymakers, and stakeholders should consider using tele-pharmacy services for improving medication adherence among older adults; however, ensuring interventions facilitate communication between patients and health care teams, and are accompanied by user training and support, is essential for technology uptake and effectiveness.

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Editor's Choice -- European Society for Vascular Surgery (ESVS) 2024 Clinical Practice Guidelines on the Management of Asymptomatic Lower Limb Peripheral Arterial Disease and Intermittent Claudication

Nordanstig,

Behrendt,

Baumgartner

et al. 2024

European Journal of Vascular and Endovascular Surgery

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Randomised trial of telephone counselling to improve participants' adherence to prescribed drugs in a vascular screening trial

Cited by 7 publications

References 31 publications

Strategies aiming to improve statin therapy adherence in older adults: a systematic review

Strategies aiming to improve statin therapy adherence in older adults: a systematic review

Factors affecting medication adherence among older adults using tele-pharmacy services: a scoping review

Editor's Choice -- European Society for Vascular Surgery (ESVS) 2024 Clinical Practice Guidelines on the Management of Asymptomatic Lower Limb Peripheral Arterial Disease and Intermittent Claudication

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