Randomised double-blind, positive-controlled trial to assess the efficacy of glucosamine/chondroitin sulfate for the treatment of dogs with osteoarthritis

McCarthy, Grainne; O’Donovan, J.; Jones, B. P.; McAllister, H.; Seed, Michael; Mooney, Carmel T.

doi:10.1016/j.tvjl.2006.02.015

Cited by 105 publications

(103 citation statements)

References 18 publications

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“…The McCarthy et al (2007) trial was multi-centered, randomized, double-blinded, and prospective which is an ideal study design. However, the method of randomization was determined by order of presentation (alternating), which introduces the risk of selection bias since the ability to anticipate treatment allocation may potentially influence the order of enrollment.…”

Section: Number Of Study Arms: Fourmentioning

confidence: 99%

“…Neil et al (2005) concludes that the determination of the minimal effective concentrations of glucosamine and chondroitin and their beneficial effects in canines require further investigation. The Johnston et al (2008) commentary refers to the Aragon et al (2007) systematic review, the Moreau et al (2003) trial, andthe McCarthy et al (2007) trial. The authors conclude that despite having conflicting results, the two studies shared similar strengths such that one can have a moderate level of comfort with the results from both studies.…”

Section: Review Articlesmentioning

confidence: 99%

“…However, statistical comparisons and treatment rankings were not provided and the magnitudes of the treatment effects were not reported. Clinical trial: glucosamine and chondroitin versus placebo or NSAID Investigators in the McCarthy et al (2007) group conducted a prospective, randomized, double-blinded study that included 42 client-owned dogs, with 35 completing the trial. The dogs could be of any breed or sex, presenting with clinical signs of chronic lameness, stiffness, joint pain, and radiological evidence of osteoarthritis of the hips and/or elbows.…”

Section: Introductionmentioning

confidence: 99%

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Glucosamine and chondroitin use in canines for osteoarthritis: A review

Bhathal¹,

Spryszak²,

Louizos³

et al. 2017

Open Vet J.

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Osteoarthritis is a slowly progressive and debilitating disease that affects canines of all breeds. Pain and decreased mobility resulting from osteoarthritis often have a negative impact on the affected canine's quality of life, level of comfort, daily functioning, activity, behaviour, and client-pet companionship. Despite limited and conflicting evidence, the natural products glucosamine hydrochloride (HCl) and chondroitin sulfate are commonly recommended by veterinarians for treating osteoarthritis in dogs. There is a paucity of well-designed clinical veterinary studies investigating the true treatment effect of glucosamine and chondroitin. The purposes of this review article are to provide a brief background on glucosamine and chondroitin use in canine osteoarthritis and to critically review the available literature on the role of these products for improving clinical outcomes. Based on critical review, recommendations for practice are suggested and a future study design is proposed.

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Section: Number Of Study Arms: Fourmentioning

confidence: 99%

Section: Review Articlesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Glucosamine and chondroitin use in canines for osteoarthritis: A review

Bhathal¹,

Spryszak²,

Louizos³

et al. 2017

Open Vet J.

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show abstract

“…In the past two decades, among all nutraceuticals, glucosamine and chondroitin sulfate have been predominantly used in the treatment of canine OA [13,[58][59][60][61]. In clinical trials, nutraceuticals such as glucosamine and chondroitin sulfate and/or undenatured type II collagen [13,[60][61][62] Crominex® -3+ [16] purified shilajit [30], avocado/soybean unsaponifiables [63], green lipped mussel [35,64] and curcumin [65] have been found significantly effective in ameliorating OA pain and have shown to be safe for long-term use in canines.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Terminalia chebula Extract for Anti-Arthritic Efficacy and Safety in Osteoarthritic Dogs

Murdock¹,

Vega³

et al. 2015

J Veterinar Sci Technol

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The present investigation was undertaken to assess anti-inflammatory and anti-arthritic efficacy and safety of T. chebula extract (TCE) in moderately osteoarthritic (OA) dogs. Dogs with OA received either 500 mg placebo or 500 mg TCE twice daily for 150 days. On a monthly basis, dogs were given a full physical exam and were evaluated for arthritic pain (overall pain, pain upon limb manipulation, and pain after physical exertion), inflammation (erythrocyte sedimentation rate, ESR), and analysis of complete blood count (CBC) and serum biomarkers of liver (bilirubin, ALT, and AST), kidney (BUN and creatinine), and heart and skeletal muscle (CK) functions. Elbow and stifle joints were radiographed on day 0 and day 150 for evaluation of arthritic progression. Dogs given TCE showed significant (P<0.01) reductions in overall pain, pain upon limb manipulation, and pain after physical exertion by day 90, with maximum effects on day 150 (81.2%, 81.5%, and 84.2%, respectively). A marked reduction in ESR coincided with pain reduction in TCE-treated dogs, which was indicative of anti-inflammatory effect of TCE. Radiographic evidence also indicated slowed progression of OA in joints examined. No significant change occurred in physical parameters, CBC parameters, or serum biomarkers in dogs on placebo or treatment, which suggested that TCE was well tolerated. It can be concluded that TCE, by having many active principles (chebulagic acid, chebulinic acid, corilagin, hydrolysable tannoids, etc.) might have provided antioxidant, anti-inflammatory and anti-arthritic effects in dogs without causing any side effects.

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“…Currently, among various nutraceuticals, glucosamine and chondroitin are the two most commonly used supplements, which provide building blocks and hydration to repair the cartilage and to minimize and slow down the progression of OA to ease inflammatory pain and discomfort [33,34,[44][45][46][47]. In a recent study, Lawley et al [23] reported that daily administration of purified Shilajit (500 mg, bid) for a period of five months provided anti-inflammatory and anti-arthritic effects in moderately arthritic dogs without producing any untoward events.…”

mentioning

confidence: 99%

Anti-Arthritic Efficacy And Safety Of Crominex® 3+ (Trivalent Chromium, Phyllanthus emblica Extract, And Shilajit) In Moderately Arthritic Dogs

Fleck¹,

Rc²,

Jt³

et al. 2014

Journal of Veterinary Science and Animal Husbandry

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The present investigation was undertaken to evaluate the therapeutic efficacy and safety of Crominex 3+ (a complex of trivalent chromium, Phyllanthus emblica (Amla) extract and purified Shilajit) in moderately arthritic dogs. Eleven client-owned moderately arthritic dogs in a randomized double-blinded study received placebo or Crominex 3+ twice daily for a period of 150 days. On a monthly basis, each dog was evaluated for arthritis associated pain (overall pain, pain upon limb manipulation and pain after physical exertion) and a full physical exam (body weight, body temperature and heart rate). At the same time intervals, dogs serum samples were examined for biomarkers of kidney (BUN and creatinine), liver (bilirubin, ALT and AST) and heart and skeletal muscle (CK) functions. Findings of this investigation revealed that dogs receiving Crominex 3+ (1000 µg chromium, 15 mg Amla extract and 15 mg purified Shilajit per day in two divided doses) exhibited a significant (P<0.05) reduction in arthritic pain noted as early as after 90 days with a maximum reduction after 150 days of treatment. Pain level remained the same or slightly increased in the dogs receiving placebo. No significant change occurred in physical parameters or serum biomarkers in dogs on placebo or Crominex 3+, which suggested that Crominex 3+ was well tolerated by arthritic dogs. In conclusion, Crominex 3+ significantly (P<0.05) ameliorated arthritic pain and improved quality of life without causing any untoward effects in moderately arthritic dogs. [3][4][5]. OA is an inflammatory joint disease characterized by chronic and progressive cartilage degeneration, osteophyte formation, subchondral sclerosis, hypertrophy of bone at the margins and changes in the synovial membrane, which eventually results in decreased stability, movement, loading, stiffness of joints, lameness and pain [6][7][8][9][10][11][12][13][14][15]. Introduction Anti-Arthritic EfficacyIn the early stages of OA, a progressive depletion of the cartilage proteoglycan leads to a net loss of matrix from the cartilage [16,17]. Breakdown and deterioration of the cartilage have been correlated with increased activities of certain enzymes including the matrix metalloproteinase (MMP). The increased cartilage lesions in OA have also been correlated with the enhanced levels of 14,16]. These cascading events lead to increased friction and inflammation in the joints. To date, there are no serum, urinary or synovial biomarkers that are specific and validated for OA [18].Common signs and symptoms associated with OA in dogs include limping, immobility, stiffness of joints, crepitus, periarticular swelling, palpable effusion, pain upon manipulation of the joint and lameness [10,[19][20][21][22][23][24][25]. The diagnosis of OA in canine patients is based upon history, physical exam and radiographic evidence. Finally, MRI findings reveal the changes of joint and cartilage degeneration consistent with OA [26][27][28][29][30].Canines with OA are treated with multipronged approaches, involving i...

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Randomised double-blind, positive-controlled trial to assess the efficacy of glucosamine/chondroitin sulfate for the treatment of dogs with osteoarthritis

Cited by 105 publications

References 18 publications

Glucosamine and chondroitin use in canines for osteoarthritis: A review

Glucosamine and chondroitin use in canines for osteoarthritis: A review

Evaluation of Terminalia chebula Extract for Anti-Arthritic Efficacy and Safety in Osteoarthritic Dogs

Anti-Arthritic Efficacy And Safety Of Crominex® 3+ (Trivalent Chromium, Phyllanthus emblica Extract, And Shilajit) In Moderately Arthritic Dogs

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