Randomised, double-blind and placebo-controlled study using new probiotic lactobacilli for strengthening the body immune defence against viral infections

Berggren, Anna; Ahrén, Irini Lazou; Larsson, Niklas; Önning, Gunilla

doi:10.1007/s00394-010-0127-6

Cited by 114 publications

(108 citation statements)

References 15 publications

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“…Furthermore, a randomized, parallel, double-blind, placebo-controlled study showed that consumption of L. plantarum HEAL 9 and L. paracasei 8700 : 2 for a 12-week period could reduce the risk of acquiring common cold infections in healthy individuals. For example, the incidence of acquiring one or more common cold episodes, the number of days with common cold symptoms, and pharyngeal symptoms were all reduced [27]. …”

Section: Probiotics For Immune Disease Prevention and Treatmentmentioning

confidence: 99%

Probiotics and immune health

Yan

Polk

2011

Current Opinion in Gastroenterology

324

190

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Purpose of review The beneficial effects of probiotics have been demonstrated in many diseases. One of the major mechanisms of probiotic action is through the regulation of host immune response. This review highlights the recent scientific research findings that advance our understanding of probiotic regulation of the host immune response with potential application for disease prevention and treatment. Recent findings Probiotic genomic and proteomic studies have identified several genes and specific compounds derived from probiotics, which mediate immunoregulatory effects. Studies regarding the biological consequences of probiotics in host immunity suggested that they regulate the functions of systemic and mucosal immune cells and intestinal epithelial cells. Thus, probiotics showed therapeutic potential for diseases, including several immune response-related diseases, such as allergy, eczema, viral infection, and potentiating vaccination responses. Summary Probiotics may provide novel approaches for both disease prevention and treatment. However, the results of clinical studies regarding probiotic application are preliminary and require further confirmation.

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Section: Probiotics For Immune Disease Prevention and Treatmentmentioning

confidence: 99%

Probiotics and immune health

Yan

Polk

2011

Current Opinion in Gastroenterology

324

190

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“…In this study the great amount of inflammatory cytokine RNA for IFN-γ, IL1β and IL17 has been obtained after 6 weeks, though in the LP+HP group (LP+HP=normal chow diet with 400μl of viable cells of L. plantarum ZDY 2013), the increase in the level of mRNA which is related to IL1β and IFN-γ has been stopped. It can be inferred from this research that L. plantarum ZDY 2013 pretreatment could prevent Th1 cell response by H. pylori infection [6].…”

Section: The Role Of L Plantarum Zdy 2013 and L Fermentum Uco-979c mentioning

confidence: 68%

The Effect of Probiotics on Immune System

Ganjbakhsh¹

2017

JBMOA

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In recent years, the research into probiotics indicates that supplementing with probiotics is probably more important than taking a multi-vitamin or antibiotics. This paper presents the interaction between host-derived probiotics and immunomodulatory. Studies have revealed probiotics can produce a unique substance that affects the expression of particular genes which are related to immune regulation in humans. The effect of gastric microbiota such as Lactobacillus fermentum and Lactobacillus plantarum is an amazing example to demonstrate how they are able to regulate the immune system. In fact, the studies indicate that L. plantarum ZDY 2013 pretreatment can prevent gastric mucosal inflammation induced by H. pylori. In addition, L. fermentum UCO-979C-obtained from human gut shows an efficient growth in the rodent (Mongolian gerbil). It can stop stimulation to produce cytokines like IL8 by H. pylori in gastric adenocarcinoma human cells (AGS)cells.

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“…Looking at the data from single studies, a daily supplementation of probiotics (mainly lactobacilli and bifidobacteria) showed a slight effect on ARI in adults, elderly, and selected at-risk populations (table 2). However, either a combined probiotic preparation (including L. gasseri, B. longum, and B. bifidum) or a symbiotic formulation (including L. rhamnosus, L. plantarum, and B. lactis) demonstrated, in randomized controlled trials, a good efficacy in shortening the duration of episodes by about 2 days and the severity of symptoms [22][23][24].…”

Section: Prevention Of Respiratory Infections In the Adult Populationmentioning

confidence: 99%

Probiotics in Respiratory Infections

Bruzzese¹,

Vecchio²,

Ruberto³

2013

World Review of Nutrition and Dietetics

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Probiotics are an established therapeutic or preventive intervention for gastrointestinal diseases and their efficacy is supported by several mechanisms, including the modulation of the immune response. However, there is evidence that the administration of probiotics may also be effective in the prevention or treatment of respiratory infections. Trials have been performed in general populations of infants and children and in populations at increased risk of respiratory infections, such as those in day care centers, schools, or hospitals, and evidence of a reduced rate of infections has been obtained in all those settings. In addition, the efficacy of probiotics to prevent respiratory infections has also been investigated in children with clinical conditions at increased risk of respiratory infections, such as those with atopy or with chronic diseases, and preliminary evidence of efficacy has been found. In adults, similar data have been obtained, although the body of evidence and the quality of data does not reach that available in childhood. Finally, the efficacy of probiotics in populations at risk of very severe respiratory infections, such as children with cystic fibrosis and preterm infants, has been investigated with promising results. However, differences in definitions, conditions, strains, and study protocols do not allow conclusions and further data are needed. In conclusion, probiotics provide a novel exciting opportunity for prevention and treatment of respiratory infections that is highly appealing in conditions of increased risk, particularly in children.Acute respiratory infections (ARI), including both upper respiratory tract infections (URTI) and lower respiratory infections (LRTI), are the most common illnesses during infancy worldwide. In developed countries, most children experience several respiratory infections (6-8 colds per year) in their first years of life. The common cold is also frequent in adults with an occurrence of 2-4 colds per year.Options for treatment of URTI are limited as it is prevalently of viral origin and generally based on symptoms. Probiotics have been proposed as therapy both in general settings and in populations at increased risk of URTI, which include conditions related to the host or to logistical conditions.

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Randomised, double-blind and placebo-controlled study using new probiotic lactobacilli for strengthening the body immune defence against viral infections

Abstract: In conclusion, intake of the probiotic strains Lactobacillus plantarum HEAL 9 (DSM 15312) and Lactobacillus paracasei 8700:2 (DSM 13434) reduces the risk of acquiring common cold infections.

Cited by 114 publications

References 15 publications

Probiotics and immune health

Probiotics and immune health

The Effect of Probiotics on Immune System

Probiotics in Respiratory Infections

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