Randomised controlled trial of melatonin for paediatric functional abdominal pain disorders

Dipasquale, Valeria; Palermo, Lisa; Barbalace, Andrea; Tumminello, Giampaolo; Romano, Claudio

doi:10.1111/jpc.16323

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…The participants were randomized to treatment with the combination of melatonin and L. Rhamnosus GG or placebo in combination with L. Rhamnosus GG for 4 weeks and the primary endpoint was defined as at least a 50% reduction in the abdominal pain index (API) at 12 weeks. There was a significant improvement in API with the treatment combination of melatonin and L. Rhamnosus GG without any adverse events [18 ▪ ]. The authors endorse that a larger study is warranted and could address their limitations of being a small single-center trial.…”

Section: Treatment and Managementmentioning

confidence: 90%

What is new with irritable bowel syndrome

Kamal,

Morneault-Gill,

Chadwick

2023

Current Opinion in Pediatrics

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Purpose of review This review aims to summarize the most up-to-date criteria for diagnosis of pediatric irritable bowel syndrome (IBS) and treatment options. It also explores recent research that has been performed evaluating risk factors, pathophysiology, and treatment designed to improve quality of life for those who suffer from IBS. IBS is a common disorder in pediatrics and one of the most common causes of abdominal pain for children; thus, it can be quite debilitating for individuals to achieve a satisfactory quality of life on a routine basis. Reliable, available treatment is needed but can be challenging to find, given the variety of symptoms and triggers involved and lack of a clear understanding of how IBS develops. Recent findings There are multiple pharmacologic and nonpharmacologic treatment options being explored and studied globally but further, larger, and well controlled studies are needed to confirm these outcomes. Summary Because pediatric IBS is one of the most common functional disorders associated with abdominal pain and can be brought on by multiple factors, management often involves addressing these individual triggers with a multifaceted treatment plan, which could include dietary changes, probiotics, medication, or psychotherapy and should be tailored to each affected individual.

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Section: Treatment and Managementmentioning

confidence: 90%

What is new with irritable bowel syndrome

Kamal,

Morneault-Gill,

Chadwick

2023

Current Opinion in Pediatrics

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“…This statement was later used as evidence that several Lactobacillus produce melatonin. For example, in a trial on abdominal pain in children, Lactobacillus and exogenous melatonin were used for the health of the patient [ 101 ], as if melatonin produced by Lactobacillus was not enough to obtain the desired effect. In another study, melatonin was shown to increase the amount of Lactobacillus previously decreased by sleep deprivation as if the production of melatonin by Lactobacillus was not enough to counterbalance the decrease in circulating melatonin [ 102 ].…”

Section: Some Proposed Mechanisms Behind the Claimed Beneficial Effec...mentioning

confidence: 99%

Melatonin: Facts, Extrapolations and Clinical Trials

2023

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Melatonin is a fascinating molecule that has captured the imagination of many scientists since its discovery in 1958. In recent times, the focus has changed from investigating its natural role as a transducer of biological time for physiological systems to hypothesized roles in virtually all clinical conditions. This goes along with the appearance of extensive literature claiming the (generally) positive benefits of high doses of melatonin in animal models and various clinical situations that would not be receptor-mediated. Based on the assumption that melatonin is safe, high doses have been administered to patients, including the elderly and children, in clinical trials. In this review, we critically review the corresponding literature, including the hypotheses that melatonin acts as a scavenger molecule, in particular in mitochondria, by trying not only to contextualize these interests but also by attempting to separate the wheat from the chaff (or the wishful thinking from the facts). We conclude that most claims remain hypotheses and that the experimental evidence used to promote them is limited and sometimes flawed. Our review will hopefully encourage clinical researchers to reflect on what melatonin can and cannot do and help move the field forward on a solid basis.

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The effect of neurotransmitters on the course of functional gastrointestinal disorders associated with emotional volitional disturbances caused by stress in children

Sliusar,

Volosovets,

Kryvopustov

et al. 2024

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Background. The medico-social significance of functional gastrointestinal disorders (FGID) in children is due to their prevalence and impact on the quality of life of patients. According to the biopsychosocial model, FGID are heterogeneous diseases that arise as a result of a complex interaction of biological, psychoemotional, and psychosocial factors. Objective: based on the generalization of available literature data, to highlight the influence of serotonin and melatonin neurotransmitters on the course of FGIR associated with emotional volitional disturbances caused by stress in children. Materials and methods. Modern domestic and international scientific literature on the influence of serotonin and melatonin on the course of FGIR associated with emotional volitional disturbances caused by stress in children was reviewed and analyzed. To search for literary sources, the Scopus, PubMed, ResearchGate, Wiley Online Library, and Google Scholar databases were studied for 2016–2024, a total of 98 sources. Results. Modern etiopathogenetic factors for the occurrence of FGIR in children are described, with the key components of their biopsychosocial model highlighted. The influence of stressors on the development of mental disorders in children with FGIR, in particular emotional and volitional changes, is considered. We have demonstrated the role of serotonin and melatonin in the regulation of mood, emotions, sleep, behavior, anxiety, depression, etc. The importance of these neurotransmitters in the occurrence of gastrointestinal symptoms in FGIR is highlighted with modern approaches to the management of children with FGIR associated with emotional volitional disturbances caused by stress being considered. A promising therapeutic direction is identified — the use of supplements of certain neurotransmitters (in particular, serotonin and melatonin) in children with this pathology. Conclusions. The analyzed literature data demonstrate the heterogeneity of FGIR in children and the importance of stressors in their development. Neurotransmitters play a significant role in the formation of the response to stress and the course of FGIR associated with emotional volitional disturbances caused by stress in children. Data on the effectiveness of serotonin and melatonin supplementation in children with FGIR are few, so there is a need for further research on this issue in order to improve the effectiveness of treatment and the quality of life of these patients.

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Randomised controlled trial of melatonin for paediatric functional abdominal pain disorders

Cited by 3 publications

References 23 publications

What is new with irritable bowel syndrome

What is new with irritable bowel syndrome

Melatonin: Facts, Extrapolations and Clinical Trials

The effect of neurotransmitters on the course of functional gastrointestinal disorders associated with emotional volitional disturbances caused by stress in children

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