Randomised Control Trial of Dexmedetomidine and Magnesium Sulfate as an Adjuvant to Ropivacaine in Supraclavicular Brachial Plexus Block

Singh, Saurabh; Raman, Rajesh; Singh, Gyan Prakash; Singh, Vinita; Kumar, Santosh; Tewari, Vandana

doi:10.5958/2321-1032.2019.00029.9

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…High-dose clonidine was not associated with an increased risk of hypotension Appendix S32. Dexmedetomidine was also associated with a higher risk of hypotension compared with placebo (RR 3.9 [95% CI 2.0, 7.5, p < .0001; 30 trials]) 5,47,[49][50][51][52][53][54][57][58][59][60][64][65][66][67][68][70][71][72][73][74][75][76]81,84,[87][88][89]93 (Appendix S33). High-dose dexmedetomidine was not associated with an increased risk ratio of hypotension (Appendix S34).…”

Section: Hypotensionmentioning

confidence: 99%

See 1 more Smart Citation

Alpha₂‐receptor agonists as adjuvants for brachial plexus nerve blocks—A systematic review with meta‐analyses

Andersen

Karlsen

Geisler

et al. 2021

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

Background:We review the efficacy and safety of dexmedetomidine and clonidine as perineural or systemic adjuvants for brachial plexus blocks (BPB). Methods:We included randomised controlled trials on upper limb surgery with BPBs in adults, comparing dexmedetomidine with clonidine or either drug with placebo.The primary outcome was duration of analgesia. Secondary outcomes included adverse and serious adverse events. The review was conducted using Cochrane standards, trial sequential analyses (TSA) and Grading of Recommendations Assessment, Development and Evaluation (GRADE). Results: We included 101 trials with 6248 patients. Overall, duration of analgesia was prolonged with both clonidine (176 min [TSA adj. 95% CI: 118, 205, p < .00001; 33 trials]) and dexmedetomidine (292 min [TSA adj. 95% CI: 245 329, p < .00001; 53 trials]), but was longer for dexmedetomidine than clonidine (205 min [TSA adj. 95% CI: 157, 254, p < .00001; 19 trials]). Compared with placebo, dexmedetomidine was associated with bradycardia (RR 4.2 [95% CI 2.2, 8.3]), and both clonidine (RR 4.5 [95% CI 1.1, 18.3]) and dexmedetomidine (RR 3.9 [95% CI 2.0, 7.5]) were associated with hypotension. Serious adverse events were mostly related to block technique. GRADErated quality of evidence was low or very low. Conclusion:Alpha2-receptor agonists used as adjuvants for BPBs lead to a prolonged duration of analgesia, with dexmedetomidine as the most efficient. Alpha2-receptor agonists were associated with increased risk of cardiovascular adverse events. The quality of evidence was low to very low.

show abstract

Section: Hypotensionmentioning

confidence: 99%

“…clonidine and placebo. 12,17,18,21,24,28,32,35,36,[39][40][41] Increased sedation was found for patients receiving dexmedetomidine in 24 trials 42,45,47,52,56,57,[59][60][61]65,67,70,71,[74][75][76]78,80,87,88,90,91,93,94 when compared with placebo. One trial reported more sedation in the placebo group than the dexmedetomidine group.…”

Section: Sedationmentioning

confidence: 99%

Alpha₂‐receptor agonists as adjuvants for brachial plexus nerve blocks—A systematic review with meta‐analyses

Andersen

Karlsen

Geisler

et al. 2021

Acta Anaesthesiol Scand

View full text Add to dashboard Cite

show abstract

Randomised Control Trial of Dexmedetomidine and Magnesium Sulfate as an Adjuvant to Ropivacaine in Supraclavicular Brachial Plexus Block

Cited by 1 publication

References 0 publications

Alpha₂‐receptor agonists as adjuvants for brachial plexus nerve blocks—A systematic review with meta‐analyses

Alpha₂‐receptor agonists as adjuvants for brachial plexus nerve blocks—A systematic review with meta‐analyses

Contact Info

Product

Resources

About

Randomised Control Trial of Dexmedetomidine and Magnesium Sulfate as an Adjuvant to Ropivacaine in Supraclavicular Brachial Plexus Block

Cited by 1 publication

References 0 publications

Alpha2‐receptor agonists as adjuvants for brachial plexus nerve blocks—A systematic review with meta‐analyses

Alpha2‐receptor agonists as adjuvants for brachial plexus nerve blocks—A systematic review with meta‐analyses

Contact Info

Product

Resources

About

Alpha₂‐receptor agonists as adjuvants for brachial plexus nerve blocks—A systematic review with meta‐analyses

Alpha₂‐receptor agonists as adjuvants for brachial plexus nerve blocks—A systematic review with meta‐analyses