Random fecal alpha-1-antitrypsin concentration in children with gastrointestinal disease

Thomas, D. Winton; Sinatra, Frank; Merritt, Russell

doi:10.1016/0016-5085(81)90140-2

Cited by 92 publications

(52 citation statements)

References 25 publications

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“…In our patient, protein-losing enteropathy was con®rmed by markedly increased faecal a 1 -antitrypsin concentration and a 1 -antitrypsin clearance [5,17]. Serum protein was slightly decreased, and serum albumin was less markedly reduced as compared to previous reports [8,9,12,19].…”

Section: Discussionmentioning

confidence: 57%

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Circumscribed intestinal protein loss with deficiency in CD4+ lymphocytes after the Fontan procedure

Koch¹,

Hofbeck²,

Feistel

et al. 1999

European Journal of Pediatrics

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There is a severe decrease of CD4+ lymphocytes of unknown origin in a patient with circumscribed intestinal protein loss after Fontan operation. Passive leakage of lymph fluid due to abnormal systemic venous pressure is not a sufficient explanation of the almost selective loss of CD4+ lymphocytes. Primary or secondary activation of the immune system may influence structural integrity and permeability of the intestinal wall and may play a triggering role in protein-losing enteropathy after the Fontan procedure.

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Section: Discussionmentioning

confidence: 57%

“…Laboratory studies usually demonstrate hypoproteinaemia, hypoalbuminaemia, lymphocytopenia und an elevated a 1 -antitrypsin clearance with increased a 1 -antitrypsin levels in stools [2,4,5,8,9,12,17,19]. However, there are no reports on lymphocyte subpopulation studies nor do data exist on radionuclide examinations in these patients.…”

Section: Introductionmentioning

confidence: 93%

Circumscribed intestinal protein loss with deficiency in CD4+ lymphocytes after the Fontan procedure

Koch¹,

Hofbeck²,

Feistel

et al. 1999

European Journal of Pediatrics

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“…Changes in intestinal microecology were measured by analysing bacterial enzyme activities (~glucuronidase, 13-glucosidase and urease) [31] and bacterial cellular fatty acid profiles in the samples [32]. Faecal TNF-0t concentration was analysed as a marker ofintestinal inflammation [33], and faecal 0t-1-antitrypsin concentration was a marker ofmucosal disorder associated with abnormal transmucosal protein loss [34].…”

Section: Methodsmentioning

confidence: 99%

Dietary therapy with Lactobacillus GG, bovine colostrum or bovine immune colostrum in patients with juvenile chronic arthritis: Evaluation of effect on gut defence mechanisms

Malin

Verronen

Korhonen³

et al. 1997

Inflammopharmacol

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The effect of dietary therapy with a human Lactobacillus strain GG (ATCC 53103), bovine colostrum, or bovine immune colostrum with specific antibodies against anaerobic intestinal bacteria on gut defence mechanisms were studied in juvenile chronic arthritis. Thirty patients with juvenile chronic arthritis were randomly allocated to receive a freeze-dried powder of Lactobacillus GG, or bovine colostrum, or bovine immune colostrum, for a two-week period. Immunologic and non-immunologic gut defence mechanisms were indirectly investigated in blood and faecal samples. In patients receiving Lactobacillus GG, the median (interquartile range) frequency of immunoglobulin-secreting cells, determined by enzyme-linked immunospot assay, increased in the IgA class from 1840 (690-2530) to 3480 (1030-13 170)/10(6) cells; p=0.02. Likewise the median (interquartile range) frequency of specific antibody-secreting cells against dietary antigens increased during the Lactobacillus GG therapy in the IgM class from 3.8 (1.4-5.0) to 11.2 (5.0-30.0)/10(6) cells; p=0.02. In addition, Lactobacillus GG therapy decreased the median (interquartile range) activity of faecal urease, which has been associated with mucosal tissue damage, from 40.3 (21.7-54.3) to 28.6 (24.5-49.4) nmol. min(-1) (mg protein)(-1); p=0.10, while, in patients receiving bovine colostrum, faecal urease activity increased (from 42.2 to 80.6; p=0.04). All findings were transient. We suggest that gut defence mechanisms are disturbed in juvenile chronic arthritis and we further suggest that orally administered Lactobacillus GG has a potential to reinforce the mucosal barrier mechanisms in juvenile chronic arthritis.

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“…An elevated stool a 1 -antitrypsin confirmed the diagnosis of a protein-losing enteropathy. 19,20 Amongst the protein-losing enteropathies, loss of lymphocyte-rich lymphatic fluid into the bowel lumen is unique to InL. 21 This accounts for the consistent finding of lymphopenia in InL but not in other protein-losing enteropathies.…”

Section: Absent Naive T Cells Is Intestinal Lymphangiectasia (Inl)mentioning

confidence: 95%

A 55-year-old man with hypogammaglobulinemia, lymphopenia, and unrelenting cutaneous warts

Lynn¹,

Knight²,

Kamoun³

et al. 2004

Journal of Allergy and Clinical Immunology

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Random fecal alpha-1-antitrypsin concentration in children with gastrointestinal disease

Cited by 92 publications

References 25 publications

Circumscribed intestinal protein loss with deficiency in CD4+ lymphocytes after the Fontan procedure

Circumscribed intestinal protein loss with deficiency in CD4+ lymphocytes after the Fontan procedure

Dietary therapy with Lactobacillus GG, bovine colostrum or bovine immune colostrum in patients with juvenile chronic arthritis: Evaluation of effect on gut defence mechanisms

A 55-year-old man with hypogammaglobulinemia, lymphopenia, and unrelenting cutaneous warts

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