2021
DOI: 10.3390/diagnostics11030420
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Randall-Type Monoclonal Immunoglobulin Deposition Disease: New Insights into the Pathogenesis, Diagnosis and Management

Abstract: Randall-type monoclonal immunoglobulin deposition disease (MIDD) is a rare disease that belongs to the spectrum of monoclonal gammopathy of renal significance (MGRS). Renal involvement is prominent in MIDD, but extra-renal manifestations can be present and may affect global prognosis. Recent data highlighted the central role of molecular characteristics of nephrotoxic monoclonal immunoglobulins in the pathophysiology of MIDD, and the importance of serum free light chain monitoring in the diagnosis and follow-u… Show more

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Cited by 9 publications
(5 citation statements)
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“…In MIDD, up to 50% of patients may have at least one extra-renal manifestation (cardiac, liver, central nervous system) but they are often asymptomatic or less symptomatic compared to patients with AL amyloidosis. 6 Cryoglobulinemia is a systemic disease presenting with broad clinical features and severity, including arthralgia, purpura, skin ulcers, neuropathy and life-threatening complications, such as hyperviscosity syndrome in type I cryoglobulin. 7 The commonest indications for a renal biopsy in MGRS are proteinuria and renal impairment that are otherwise unexplained.…”
Section: The Spectrum Of Renal Histopathology In Mgrsmentioning
confidence: 99%
“…In MIDD, up to 50% of patients may have at least one extra-renal manifestation (cardiac, liver, central nervous system) but they are often asymptomatic or less symptomatic compared to patients with AL amyloidosis. 6 Cryoglobulinemia is a systemic disease presenting with broad clinical features and severity, including arthralgia, purpura, skin ulcers, neuropathy and life-threatening complications, such as hyperviscosity syndrome in type I cryoglobulin. 7 The commonest indications for a renal biopsy in MGRS are proteinuria and renal impairment that are otherwise unexplained.…”
Section: The Spectrum Of Renal Histopathology In Mgrsmentioning
confidence: 99%
“…It is frequently associated with plasma cell disorders such as multiple myeloma (MM) or other B cell lymphoproliferative disorders though, sometimes no clonal B lymphocytes/plasma cells can be identified. LCDD typically involves organs, the kidneys being the cardinal organ involved, but also rarely the heart, liver and peripheral nerves [1][2][3][4][5][6][7] .…”
Section: Introductionmentioning
confidence: 99%
“…Monoclonal immunoglobulin deposition disease (MIDD) is a rare complication of clonal B-cell disorder. 7,8 The disease is caused by linear deposits of monoclonal immunoglobulins, usually light chains (LCDD), and sometimes heavy chains (HCDD) or both (LHCDD), along basement membranes. MIDD can occur either in the context of multiple myeloma or monoclonal gammopathy of renal significance.…”
mentioning
confidence: 99%
“…Hutt et al 5 and Wakfie-Corieh et al 6 highlighted that cardiac and extracardiac uptakes are not specific for ATTR amyloidosis and must be interpreted in the clinical and biological context to avoid pitfalls. Monoclonal immunoglobulin deposition disease (MIDD) is a rare complication of clonal B-cell disorder 7,8 . The disease is caused by linear deposits of monoclonal immunoglobulins, usually light chains (LCDD), and sometimes heavy chains (HCDD) or both (LHCDD), along basement membranes.…”
mentioning
confidence: 99%
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