2019
DOI: 10.1039/c9sc04389f
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Raman observation of a molecular signaling pathway of apoptotic cells induced by photothermal therapy

Abstract: Plasmonic nanoparticle (NP)-mediated photothermal therapy (PPTT) has been explored as a minimally invasive approach to cancer therapy and has progressed from concept to the early stage of clinical trials. Better understanding of the cellular and molecular response to PPTT is crucial for improvement of therapy efficacy and advancement of clinical application. However, the molecular mechanism underlying PPTT-induced apoptosis is still unclear and under dispute. In this work, we used nuclear-targeting Au nanostar… Show more

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Cited by 23 publications
(26 citation statements)
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“…Agarose Gel Electrophoresis was performed as described previously 38 . DNA was extracted using a GeneJET Genomic DNA Purification kit (Thermo, USA).…”
Section: Methodsmentioning
confidence: 99%
“…Agarose Gel Electrophoresis was performed as described previously 38 . DNA was extracted using a GeneJET Genomic DNA Purification kit (Thermo, USA).…”
Section: Methodsmentioning
confidence: 99%
“…The following primer sequences that were used are shown in Agarose Gel Electrophoresis. Agarose Gel Electrophoresis was performed as described previously 34 . DNA was extracted using a GeneJET Genomic DNA Puri cation kit (Thermo, USA).…”
Section: Methodsmentioning
confidence: 99%
“…[6][7][8][9][10] PTT is a novel strategy of cancer treatment that converts near-infrared (NIR) light to heat and possesses low side effects, noninvasiveness, and high spatiotemporal selectivity. [11][12][13][14] However, due to the restriction of the heterogeneous heat distribution in tumor tissue, PTT would lead to unsatisfactory tumor ablation and cause damage to the surrounding normal cells and tissues, and therefore is known as a non-specic treatment. [15][16][17] As a new type of treatment, CDT relies on the Fenton reaction to catalyze the generation of highly oxidative hydroxyl radicals (cOH) from hydrogen peroxide (H 2 O 2 ) to damage biomolecules (such as DNA and proteins) in cancer cells.…”
Section: Introductionmentioning
confidence: 99%