A pH-responsive ultrathin Cu-based nanoplatform for specific photothermal and chemodynamic synergistic therapy

Hu, Tingting; Yan, Liang; Wang, Zhengdi; Shen, Weicheng; Liang, Ruizheng; Yan, Dongpeng; Wei, Min

doi:10.1039/d0sc06742c

Cited by 85 publications

(64 citation statements)

References 50 publications

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“…[ 23 ] CDT provides unique superiorities compared with other cancer treatments, but the relatively limited treatment benefits largely compromise its wide clinical application in cancer treatment. Generally, CDT efficacy depends on the reaction rate of the introduced Fenton/Fenton‐like reaction, which is usually influenced by the metal catalyst, [ 24 ] H 2 O 2 concentration, [ 25 ] pH, [ 26 ] and external energy field. [ 27 ] Accordingly, various strategies by manipulating the limiting factors to reinforce the intratumoral Fenton/Fenton‐like reaction have been designed and reported to enhance CDT performance for maximizing the tumor therapeutic efficacy.…”

Section: Emerging Strategies To Reinforce Fenton/fenton‐like Reactions For Enhanced Chemodynamic Therapymentioning

confidence: 99%

Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy

et al. 2021

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Chemodynamic therapy (CDT) uses the tumor microenvironment‐assisted intratumoral Fenton reaction for generating highly toxic hydroxyl free radicals (•OH) to achieve selective tumor treatment. However, the limited intratumoral Fenton reaction efficiency restricts the therapeutic efficacy of CDT. Recent years have witnessed the impressive development of various strategies to increase the efficiency of intratumoral Fenton reaction. The introduction of these reinforcement strategies can dramatically improve the treatment efficiency of CDT and further promote the development of enhanced CDT (ECDT)‐based multimodal anticancer treatments. In this review, the authors systematically introduce these reinforcement strategies, from their basic working principles, reinforcement mechanisms to their representative clinical applications. Then, ECDT‐based multimodal anticancer therapy is discussed, including how to integrate these emerging Fenton reinforcement strategies for accelerating the development of multimodal anticancer therapy, as well as the synergistic mechanisms of ECDT and other treatment methods. Eventually, future direction and challenges of ECDT and ECDT‐based multimodal synergistic therapies are elaborated, highlighting the key scientific problems and unsolved technical bottlenecks to facilitate clinical translation.

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Section: Emerging Strategies To Reinforce Fenton/fenton‐like Reactions For Enhanced Chemodynamic Therapymentioning

confidence: 99%

Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy

et al. 2021

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“…Wei and co-workers synthesized CuFe-LDH nsnosheets with the thickness of ≈1.3 nm using a "bottomup" method, and loaded glucose oxidase onto the nanosheets to build a multifunctional nanosystem (GOD/CuFe-LDH). [77] In a weak acid environment, the surface of the CuFe-LDHs would Reproduced with permission. [63] Copyright 2018, Wiley-VCH.…”

Section: Photothermal Performance Of the Snms Under Laser Irradiationmentioning

confidence: 99%

“…Wei and co‐workers synthesized CuFe–LDH nsnosheets with the thickness of ≈1.3 nm using a “bottom‐up” method, and loaded glucose oxidase onto the nanosheets to build a multifunctional nanosystem (GOD/CuFe–LDH). [ 77 ] In a weak acid environment, the surface of the CuFe–LDHs would be etched, and the photogenerated electron–hole pairs increased due to defects caused by etching. As a result, the GOD/CuFe–LDH exhibited acid‐enhanced photothermal performance.…”

Section: Photothermal Energy Conversion Of the Snmsmentioning

confidence: 99%

Recent Progress of Sub‐Nanometric Materials in Photothermal Energy Conversion

Wang

2021

Advanced Science

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Sub-nanometric materials (SNMs) are an attractive scope in recent years due to their atomic-level size and unique properties. Among various performances of SNMs, photothermal energy conversion is one of the most important ones because it can efficiently utilize the light energy. Herein, the SNMs with photothermal energy conversion behaviors and their applications are reviewed. First, a hydrothermal/solvothermal method for the synthesis of SNMs is systematically discussed, including the LaMer pathway and the cluster-nuclei coassembly pathway. Based on this synthetic strategy, many kinds of SNMs with different morphologies are successfully prepared, such as nanorings, nanowires, nanosheets, and nanobelts. These SNMs exhibit excellent photothermal performance under the laser or solar irradiation according to their different light absorption ranges. These enhanced absorption performances of SNMs are induced by the mechanism of plasmonic localized heating or nonradiative relaxation. Finally, the applications of the photothermal SNMs are illustrated. The SNMs with photothermal behaviors can be widely applied in the fields of solar vapor generation, biomedicine, and light-responsive composites construction. It is hoped that this review can provide new viewpoints and profound understanding to the SNMs in photothermal energy conversion.

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“…[47] 2) Weakly acidic TME. [48] The pH of TME is not the optimal pH for Fenton or Fenton-like reaction. 3) High reductive substances level, such as glutathione (GSH) and H 2 S. [49,50] The existence of these reductive substances will neutralize the produced oxidative •OH, resulting in an unsatisfactory therapeutic efficiency.…”

Section: Introductionmentioning

confidence: 99%

Nanocatalyst‐Mediated Chemodynamic Tumor Therapy

Zhang

Wan

et al. 2021

Adv Healthcare Materials

132

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Traditional tumor treatments, including chemotherapy, radiotherapy, photodynamic therapy, and photothermal therapy, are developed and used to treat different types of cancer. Recently, chemodynamic therapy (CDT) has been emerged as a novel cancer therapeutic strategy. CDT utilizes Fenton or Fenton-like reaction to generate highly cytotoxic hydroxyl radicals (•OH) from endogenous hydrogen peroxide (H 2 O 2 ) to kill cancer cells, which displays promising therapeutic potentials for tumor treatment. However, the low catalytic efficiency and off-target side effects of Fenton reaction limit the biomedical application of CDT. In this regard, various strategies are implemented to potentiate CDT against tumor, including retrofitting the tumor microenvironment (e.g., increasing H 2 O 2 level, decreasing reductive substances, and reducing pH), enhancing the catalytic efficiency of nanocatalysts, and other strategies. This review aims to summarize the development of CDT and summarize these recent progresses of nanocatalyst-mediated CDT for antitumor application. The future development trend and challenges of CDT are also discussed.

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A pH-responsive ultrathin Cu-based nanoplatform for specific photothermal and chemodynamic synergistic therapy

Abstract: A pH-responsive multifunctional nanosystem was synthesized by loading glucose oxidase (GOD) onto CuFe-layered double hydroxide (LDH) nanosheets, which exhibited synchronous acid-enhanced/responsive photothermal and chemodynamic synergistic therapy.

Cited by 85 publications

References 50 publications

Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy

Manipulating Intratumoral Fenton Chemistry for Enhanced Chemodynamic and Chemodynamic‐Synergized Multimodal Therapy

Recent Progress of Sub‐Nanometric Materials in Photothermal Energy Conversion

Nanocatalyst‐Mediated Chemodynamic Tumor Therapy

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