Raman Imaging of Layered Soft Contact Lenses

Krysztofiak, Katarzyna; Ciężar, Kamila; Kościński, Mikołaj

doi:10.5301/jabfm.5000329

Cited by 3 publications

(4 citation statements)

References 20 publications

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“…These lenses have low water content in the core and then transition to higher water content (approaching 100%) at the surface, creating a hydrophilic layer aimed at producing superior on-eye performance in terms of comfort. [7][8][9][10] Delefilcon A lenses have been shown to be comfortable and convenient to use. 11,12 Recently, 2-methacryloyloxyethyl phosphorylcholine (MPC)-a substance designed using a biomimetic approach to match the structure of phospholipids on cellular membrane surface and which has many properties that make it highly suitable for incorporation into a monthly replacement contact lens 13,14 -has been included in the development of a new lehfilcon A monthly replacement daily wear water gradient contact lens.…”

Section: Introductionmentioning

confidence: 99%

Safety and Efficacy of a New Water Gradient Biomimetic Monthly Replacement Spherical Contact Lens Material (Lehfilcon A)

Wesley¹,

Giedd²,

Hines³

et al. 2022

OPTH

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Purpose The objective of this study was to evaluate the safety and performance of the investigational lens, lehfilcon A, when worn in a daily wear modality and replaced monthly as compared to the commercially available comfilcon A contact lens. Methods This was a multicenter, prospective, controlled, double-masked, randomized, parallel-group clinical study with bilateral lens wear for 3 months. In all, 115 subjects completed the study (77 with test lehfilcon A and 38 with control comfilcon A contact lenses). Distance visual acuity (VA) was assessed using Snellen VA. Lens performance was assessed by examining lens fit/movement, centration, front surface wettability and front/back surface deposits using slit-lamp biomicroscopy. Results At the 3-month follow-up visit, all eyes had a distance VA of 20/20 or better. Further, lens fit/movement was assessed as optimal in 92.9% of the eyes with lehfilcon A and 89.2% with comfilcon A. There were no ratings of unacceptably tight or loose fits for either contact lens material. Lens centration was assessed as optimal in 98.7% of eyes with lehfilcon A and 94.6% with comfilcon A. For front and back surface deposits, both materials showed minimal lens surface deposits. Front surface wettability was assessed as grade 0 or 1 for most of the study lenses in both lens groups across all attended study visits. There were no ocular adverse events related to the study lenses. Conclusion Overall, lehfilcon A showed excellent VA, optimal lens fitting characteristics, a clean surface, high wettability, and low risk for adverse events after 3 months of lens wear.

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Section: Introductionmentioning

confidence: 99%

Safety and Efficacy of a New Water Gradient Biomimetic Monthly Replacement Spherical Contact Lens Material (Lehfilcon A)

Wesley¹,

Giedd²,

Hines³

et al. 2022

OPTH

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“…75 These results were consistent with findings on ocular aberrations, which were not affected by wearing time in a study comparing measures 20 min and 8 hr after CL insertion. 77 As for the subjective comfort, quality of vision also appeared to remain consistent over longer term, with values on a visual analogue scale (1)(2)(3)(4)(5)(6)(7)(8)(9)(10) showing no changes at two weeks (8.061.9), one month (8.161.2), and two months (8.461.1). 73 Overall, available literature indicates that delefilcon A (SHy) is associated with high quality of vision and high comfort ratings, which are retained even after extremely long wearing times.…”

Section: Effect Of Wear and Wear Duration On Comfort And Quality Of V...mentioning

confidence: 88%

“…wet weight 2 dry weight wet weight ; [3] where wet weight was achieved weighting the CL just after blister removal (or after in vitro incubation), and the dry weight was the weight after heating the CL at 105°C for 1 hr and then cooling it down in a desiccator for 30 min. After 1 hour, delefilcon A (SHy) showed the lowest relative dehydration (;10%), slightly lower than senofilcon A (SHy), comfilcon A (SHy), and omafilcon A (Hy) and largely lower than etafilcon A (Hy).…”

Section: Dehydrationmentioning

confidence: 99%

“…Fifteen years after the introduction of silicone-hydrogel contact lenses (SHy-CLs) in 1999, 1 delefilcon A was released and described as based on a water-gradient (WG) technology by the manufacturer. This CL is made of a SHy core of low (33%) equilibrium water content (EWC) surrounded by an interpenetrating anchoring zone of 1 to 2 micrometers 2 and a hydrogel (Hy) coating of 5 to 6 micrometers, 3 with an EWC of 80%. Few years ago, an outer thin layer with a porous morphology was observed also for filcon V (SHy), 4,5 although these CLs are not classified as WG-CLs.…”

Section: Introductionmentioning

confidence: 99%

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Physical Properties and Interaction With the Ocular Surface of Water-Gradient Contact Lenses

Ponzini

Recchioni²,

Cheloni³

et al. 2023

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Since the introduction of silicone hydrogel contact lenses, many silicone-hydrogel materials have been produced, including water-gradient contact lenses with a silicone hydrogel core and a thin hydrogel outer layer (e.g., delefilcon A, verofilcon A, and lehfilcon A). Their properties have been investigated in various studies assessing both the chemical-physical characteristics and the comfort, but the overall picture is not always consistent. In this study, water-gradient technology is reviewed by looking at basic physical properties both in vitro and in vivo and at the interaction with the human ocular surface. Surface and bulk dehydration, surface wetting and dewetting, shear stress, interaction with tear components and with other environmental compounds, and comfort are discussed.

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Experimental study of the mechanisms leading to the formation of glistenings in intraocular lenses by Raman spectroscopy

Rusciano¹,

Capaccio²,

Pesce³

et al. 2019

Biomed. Opt. Express

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Raman Imaging of Layered Soft Contact Lenses

Abstract: Data collected in this experiment confirm a water gradient at the delefilcon A lens surface.

Cited by 3 publications

References 20 publications

Safety and Efficacy of a New Water Gradient Biomimetic Monthly Replacement Spherical Contact Lens Material (Lehfilcon A)

Safety and Efficacy of a New Water Gradient Biomimetic Monthly Replacement Spherical Contact Lens Material (Lehfilcon A)

Physical Properties and Interaction With the Ocular Surface of Water-Gradient Contact Lenses

Experimental study of the mechanisms leading to the formation of glistenings in intraocular lenses by Raman spectroscopy

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