Ram Semen Prostaglandin Concentration and its Effect on Fertility

Dimov, V.; Georgiev, G.

doi:10.2527/jas1977.4461050x

Cited by 26 publications

(4 citation statements)

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“…Prostaglandins were also detected in the ram AGF, in agreement with an early study by Dimov and Georgiev (1977), high concentrations of these molecules exist in the semen of rams. Prostaglandins have immunosuppressive activity (Kelly, 1997) and promote sperm transportation by stimulating smooth‐muscle contractions in the male and female reproductive tract (Hawk, 1983).…”

Section: Discussionsupporting

confidence: 91%

Untargeted metabolomic profiling of accessory sex gland fluid from Morada Nova rams

Sousa

Lucini

Ajmone‐Marsan

et al. 2020

Molecular Reproduction Devel

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The present study was conducted to characterize the metabolome of accessory gland fluid (AGF) of locally adapted Morada Nova rams, raised in the Brazilian Northeast. AGF was collected by an artificial vagina from five vasectomized rams. Metabolites were identified by gas chromatography-mass spectrometry (GC/MS) and high-performance liquid chromatography-mass spectrometry (LC/MS), with the support of Human Metabolome Database, PubChem, LIPID Metabolites, Pathways Strategy databases, and MetaboAnalyst platforms. There were 182 and 190 metabolites detected by GC/MS and LC/MS, respectively, with an overlap of one molecule. Lipids and lipid-like molecules were the most abundant class of metabolites in the ram AGF (127 compounds), followed by amino acids, peptides, and analogs(103 metabolites). Considering all GC/MS and LC/MS, fructose, glycerol, citric acid, D-mannitol, D-glucose, and L-(+)-lactic acid were the most abundant single metabolites present in the ram AGF. Meaningful pathways associated with AGF metabolites included glycine, serine and threonine metabolism; pantothenate and CoA biosynthesis; galactose metabolism; glutamate metabolism and phenylalanine metabolism, and so forth. In conclusion, the combined use of LC/MS and GC/MS was essential for getting a holistic view of the compounds embedded in the ram AGF. Chemical analysis of the accessory sex gland secretion is relevant for understanding sperm function and fertilization. K E Y W O R D S accessory sex gland, GC/MS, LC/MS, metabolome, ovine 410 | SOUSA ET AL.

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Section: Discussionsupporting

confidence: 91%

Untargeted metabolomic profiling of accessory sex gland fluid from Morada Nova rams

Sousa

Lucini

Ajmone‐Marsan

et al. 2020

Molecular Reproduction Devel

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“…Sidhu and Gill (1992) observed a negative correlation between the levels of immunoreactive prolactin in semen and the motility and viability of spermatozoa. Concentrations of prostaglandins, testosterone, and estrogen in the semen have been suggested as indicative of the reproductive status of the bull and ram (Dimov and Georgiev, 1977). The concentration of prostaglandin E and testosterone in the SP of bulls of good fertility is significantly higher than in bulls of low fertility (Shore et al, 2003).…”

Section: Biochemical Constituents Of Sp and Their Functionsmentioning

confidence: 99%

Seminal Plasma: An Essential Attribute to Spermatozoa

Juyena¹,

Stelletta²

2012

Journal of Andrology

221

169

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The biochemical composition of seminal plasma (SP) is very complex and variable among species. Advances in reproductive technologies reveal SP as a nutritive-protective medium for sperm cells suspended in it, and some SP components are very important for sperm metabolism, as well as sperm function, survival, and transport in the female reproductive tract. Biochemistry of SP is a relatively modern but rapidly expanding field of research, particularly concerning the biological significance of the various biochemical constituents of SP. However, identification of active factors in SP and mechanisms by which they act are not sufficiently understood in different species. Especially in camelids, the origin, composition, and function of the viscous component of SP remain a mystery, and only some biochemical and morphological characteristics of SP have been described. In this review, we focus on the current understanding of physiological and biochemical properties of SP in ruminants and camelids.

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“…Consequently, these two actions could be looked on as a suction pump transporting the spermatozoa into the uterus, and may be due to the PGs present in human semen (Poyser, 1981). In fact, addition of PGs to intravaginally inseminated ejaculates has been shown to increase the fertilization rate in rabbits (Chang et al, 1973;Spilman et al, 1973) and sheep (Dimov & Georgiev, 1977), most probably by increasing sperm transport in the female repro¬ ductive tract through effects on the smooth musculature (Mandi, 1972;Chang et al, 1973). However, the present data obtained by in-vivo alterations of PG levels in rabbits show that reduction of seminal PGs does not decrease the fertilization rate.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics of non-steroidal anti-inflammatory drugs in male rabbits after acute and chronic administration and effect of chronic treatment on seminal prostaglandins, sperm quality and fertility

Löscher¹,

Lüttgenau²,

Schlegel³

et al. 1988

Reproduction

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Summary. The pharmacokinetics of various non-steroidal anti-inflammatory drugs were determined to find dosage regimens by which drug concentrations known as active from human anti-inflammatory therapy could be reached and maintained in rabbits during continued administration. Based on the pharmacokinetics and si de\ x=req-\ effects of the different drugs, phenylbutazone was selected for the fertility experiments. Treatment of male rabbits with phenylbutazone for 9 consecutive days significantly reduced seminal concentrations of PGE-2 and PGF-2\g=a\and tended to increase ejaculate volumes, sperm motility, and fertility. These results indicate that, at least in rabbits, inhibition of PG synthesis by prolonged treatment with non-steroidal anti-inflammatory drugs does not impair male fertility. Instead, chronic treatment with the drugs at non-toxic doses may improve sperm quality and fertility.

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Ram Semen Prostaglandin Concentration and its Effect on Fertility

Cited by 26 publications

References 0 publications

Untargeted metabolomic profiling of accessory sex gland fluid from Morada Nova rams

Untargeted metabolomic profiling of accessory sex gland fluid from Morada Nova rams

Seminal Plasma: An Essential Attribute to Spermatozoa

Pharmacokinetics of non-steroidal anti-inflammatory drugs in male rabbits after acute and chronic administration and effect of chronic treatment on seminal prostaglandins, sperm quality and fertility

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