“…Activation involves Ca 2+ binding and GFL‐GFR recognition, culminating in homodimerization, autophosphorylation, and downstream signaling activation [66] . This influences multiple pathways, including PI3K/AKT, RAS/RAF/MEK/ERK, JAK2/STAT3, and PLC‐γ, impacting cell proliferation, survival, and differentiation [67] . Aberrations in RET and overexpression are discerned across a wide array of cancers, including breast, pancreatic, colorectal, melanoma, lung, and prostate cancers, contributing to tumor proliferation, invasion, and migration [68] .…”