Raised Serum Levels of IgE in Infectious Mononucleosis

Nordbring, Folke; Gunnar, S; Johansson, Ӧlle; Espmark, Åke

doi:10.3109/inf.1972.4.issue-2.10

Cited by 34 publications

(14 citation statements)

References 15 publications

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“…IgD response in IM often occurred later and to a lesser degree than the responses of other Igs, an obser vation that substantiates what has been suggested by previous studies [2,27,31]. Our observation that IgD peaked in various persons at widely varying times might be due to the striking differences in its rate of synthesis [35].…”

Section: Discussionsupporting

confidence: 77%

“…Our study verifies by sequential observations of in dividual patients the results of previous reports re garding enhancement of IgM, IgA, and IgG produc tion during acute IM [6,27,38,42], It also may ex plain the inconsistency noted by some reports, partic ularly regarding IgA and IgG [6,27,43]. Such incon sistency could be, at least partly, due to comparing the patient's Ig levels with 'normal controls' or with 'ex pected normal ranges' rather than using sequential comparisons on the same patient.…”

Section: Discussionsupporting

confidence: 71%

“…Findings from studies on immunoglobulin (Ig) re sponses in infectious mononucleosis (IM) have most ly suggested an enhanced production of IgM during the acute illness but have been inconsistent regarding other Igs [2,6,27,31,38,42,43]. Two major factors probably contributed to this inconsistency, the dura tion of illness at the time of blood sampling and the lack of sequential analysis in most of those studies.…”

Section: Introductionmentioning

confidence: 96%

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Sequential Changes of the Five Immunoglobulin Classes and Other Responses in Infectious Mononucleosis

Bahna

Heiner

Horwitz

1984

Int Arch Allergy Immunol

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Serum total IgG, IgA, IgM, IgD, and IgE concentrations, heterophil antibody titer, Epstein-Barr virus (EBV)-specific antibodies titer, and hematologic changes were studied longitudinally in 19 patients with EBV-induced infectious mononucleosis who were followed up for 1.5–34 months. In 9 patients, the changes in these variables were compared with baseline data on a pre-illness serum sample. All 5 immunoglobulins (Ig) showed a significant rise during the acute illness followed by a drop during convalescence, and a gradual ‘normalization’ within several months to a year. On the average, IgE peaked to 276% during the first week, IgM to 176% at about 10 days, IgA to 154% at 15–20 days, IgG to 135% at 10–15 days, and IgD to 141% during the first 2 months after onset. IgE and IgM levels were significantly suppressed during convalescence by an average of about 40 and 25% of pre-illness level, respectively. A relationship was noted between Ig rise and the increase in circulating atypical lymphocytes. The data clearly demonstrate the polyclonal nature of Ig production during the acute phase of EBV-induced mononucleosis, with a striking and early reactivity of IgE.

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Section: Discussionsupporting

confidence: 77%

Section: Discussionsupporting

confidence: 71%

Section: Introductionmentioning

confidence: 96%

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Sequential Changes of the Five Immunoglobulin Classes and Other Responses in Infectious Mononucleosis

Bahna

Heiner

Horwitz

1984

Int Arch Allergy Immunol

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“…Conversely, many observations report high TE levels in those situations where at least some T-cell functions are reduced. In diseases such as Hodgkin's disease (30), Wiskott-Aldrich syndrome (31), and infectious mononucleosis (32) where Tcell function is suppressed and after T-suppressive manipulations such as thymectomy (33), irradiation (34), and treatment with antilymphocyte serum (35), TE production is enhanced. Indeed, a soluble factor apparently obtained from thymocytes has been isolated that can suppress TE responses (36).…”

Section: Discussionmentioning

confidence: 99%

The effect of anti-mu suppression of gammaM and gammaG on the production of gammaE.

Dwyer

Rosenbaum

Lewis

1976

The Journal of Experimental Medicine

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Newbonr mice were treated from the day of birth with either bovine gamma globulin or anti-mu chain sera. The latter was administered using a protocol known to produce suppression of gammaM, gammaG, and gammaA production. Subsequent immunization with ovalbumin (OA) in alum was attempted to see if suppression of gammaM, gammaG, and gammaA classes of antibody would also be accompanied by suppression of gammaE-producing capacity. gammaG and gammaM antibody to OA and mercaptoethanol-resistant (gammaG) antibody to OA were measured by passive hemagglutination; gammaG and gammaE anti-OA antibodies were measured by passive cutaneous anaphylaxis. Anti-mu suppression was achieved with significant reduction in gammaM and gammaG antibodies. gammaE antibodies were not affected, suggesting an ontogenetic development for gammaE-bearing lymphocytes independent of the previously described gammaM to gammaG to gammaA ontogenetic sequence.

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“…In fact, there are some reports of raised IgE levels in the early phase of mono nucleosis [1,13] and therefore an associa tion between EBV infection and 'allergic breakthrough' should be considered. In the present study we show that atopic children have significantly raised serum titers of EBV antibodies and possibly a higher fre quency of EBV seropositivity than agematched nonatopic children.…”

mentioning

confidence: 99%

Epstein-Barr Virus Antibodies in Children with Atopic Disease

Strannegård

1981

Int Arch Allergy Immunol

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The prevalence and titers of antibodies to human herpetoviruses as well as rubella and mumps viruses were determined in 98 children with atopic diseases and in 55 nonatopic control children. The only significant difference between the two groups was found as regards Epstein-Barr virus (EBV) antibodies, which were found in higher titers in atopic children of all ages. Increased levels of EBV antibodies were found both in children with asthma and atopic dermatitis. The frequency of seropositivity for EBV was slightly higher in atopies than in controls in all age-groups, but the differences observed were not statistically significant. The possibility that EBV, which is a B-cell mitogen, has a pathogenic role in the hyperproduction of IgE and development of atopic disease, should be considered.

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Raised Serum Levels of IgE in Infectious Mononucleosis

Cited by 34 publications

References 15 publications

Sequential Changes of the Five Immunoglobulin Classes and Other Responses in Infectious Mononucleosis

Sequential Changes of the Five Immunoglobulin Classes and Other Responses in Infectious Mononucleosis

The effect of anti-mu suppression of gammaM and gammaG on the production of gammaE.

Epstein-Barr Virus Antibodies in Children with Atopic Disease

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