Raised serum hCG in a male patient caused by primary jejunal choriocarcinoma.

Chan, Gcf; Ng, Wai-Kuen; Chua, Dtt; Wu, P. C.

doi:10.1136/jcp.51.5.413

Cited by 12 publications

(7 citation statements)

References 13 publications

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“…Reported sites for nongestational choriocarcinoma include lungs, peritoneum, liver, gall bladder, colon, urinary tract, pineal gland, retroperitoneum, stomach and mediastinum 5–11 …”

Section: Discussionmentioning

confidence: 99%

“…Reported sites for nongestational choriocarcinoma include lungs, peritoneum, liver, gall bladder, colon, urinary tract, pineal gland, retroperitoneum, stomach and mediastinum. [5][6][7][8][9][10][11] Our woman, however, presented with primary ovarian nongestational choriocarcinoma. The presence of pulmonary lesions suggestive of lung metastasis in our woman with a markedly raised level of beta hCG led to a review of her histology.…”

Section: Discussionmentioning

confidence: 99%

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Nongestational choriocarcinoma arising from a primary ovarian tumour

Oladipo

Mathew

Oriolowo

et al. 2007

BJOG

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“…Reported sites for nongestational choriocarcinoma include lungs, peritoneum, liver, gall bladder, colon, urinary tract, pineal gland, retroperitoneum, stomach and mediastinum 5–11 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Nongestational choriocarcinoma arising from a primary ovarian tumour

Oladipo

Mathew

Oriolowo

et al. 2007

BJOG

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“…In this regard, the fact that the processes of growth, inflammation, metastasis, apoptosis, angiogenesis and immune suppression are shared between the physiological state of pregnancy and the pathological state of cancer assumes relevance. Of additional interest are observations that in cancer patients the presence of hCG (or more often, the β subunit) is associated with poor prognosis in many instances [ 4 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

The transgenic expression of the β-subunit of human chorionic gonadotropin influences the growth of implanted tumor cells

et al. 2018

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The beta subunit of human chorionic gonadotropin (βhCG) is secreted by various tumors, and its presence associated with poor prognosis. Though exogenous hCG elicits the synthesis of molecules associated with angiogenesis, invasion, immune suppression and chemoresistance from responsive tumor cells in vitro, the influence of cell-extrinsic βhCG on tumorigenesis in vivo has not been adequately explored. Female C57BL/6−/− × FVBβhCG/− F1 transgenic mice demonstrated ovarian hyperplasia and pituitary adenomas; transcripts of hCG-driven, tumor-associated molecules were heightened in the pituitary. Upon the implantation of Lewis Lung Carcinoma cells (murine lung tumor cells derived from C57BL/6 mice) in transgenic mice, tumor incidence and volume were enhanced, and increased transcription and expression of hCG-driven, tumor-associated molecules was observed in excised tumors. While treatment of these mice with Cabergoline (a potent dopamine receptor agonist) had no significant effects, ovariectomy resulted in a reduction in the lag phase, accompanied by an increase in tumor incidence and volume upon Lewis Lung Carcinoma cell implantation. In tumors derived from Lewis Lung Carcinoma cell-implanted ovariectomized, transgenic mice, the transcription and expression of hCG-driven, tumor-associated molecules remained elevated and enhanced animal mortality was observed. Cell-extrinsic βhCG can therefore induce pro-tumorigenic effects in vivo (even on tumor lineages not part of the reproductive axis), with ovarian products mediating an ameliorating influence.

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“…4,5 Although these tumors can occur in the small intestine, this site of origin is rare and only a few cases have been reported in the English literature. [6][7][8][9][10][11][12][13] We report the case of a man with rapidly progressive primary choriocarcinoma of the jejunum. b Multiple liver metastases can be seen on the CT scan done 1 month later.…”

Section: Introductionmentioning

confidence: 99%

Primary Choriocarcinoma of the Jejunum: Report of a Case

et al. 2003

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We report a case of primary choriocarcinoma of the jejunum in a 45-year-old man, which was finally diagnosed by immunohistochemical analysis of a surgically resected specimen. Despite combined systemic chemotherapy, the patient died of progressive liver metastases 5 months after surgery. The serum human chorionic gonadotropin (HCG) level increased dramatically as the liver tumor progressed. According to our review of the 13 cases of primary or secondary choriocarcinoma of the small intestine reported in the English-language literature up until 2001, the characteristic symptoms are massive gastrointestinal bleeding and elevation of the serum HCG. Early diagnosis and prompt initiation of chemotherapy provide the only chance of improving the extremely poor prognosis associated with this rare neoplasm.

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Raised serum hCG in a male patient caused by primary jejunal choriocarcinoma.

Cited by 12 publications

References 13 publications

Nongestational choriocarcinoma arising from a primary ovarian tumour

Nongestational choriocarcinoma arising from a primary ovarian tumour

The transgenic expression of the β-subunit of human chorionic gonadotropin influences the growth of implanted tumor cells

Primary Choriocarcinoma of the Jejunum: Report of a Case

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